
The tetanus vaccine is a vital step in preventing tetanus, a serious bacterial infection that can cause painful muscle stiffness and spasms. While the vaccine is safe for most people, it can cause side effects, including muscle pain and body aches. Other common side effects include pain, redness, and swelling at the injection site, fever, headache, and fatigue. These side effects are typically mild and will usually resolve within a few days. However, in rare cases, the vaccine can cause severe allergic reactions, such as anaphylaxis, and shoulder injuries related to vaccine administration (SIRVA). It is important to seek medical advice if symptoms persist or become concerning.
| Characteristics | Values |
|---|---|
| Common side effects | Pain, redness, swelling at the injection site, fever, headache, fatigue, nausea, muscle pain and body aches |
| Serious side effects | Rare but may include severe allergic reactions, anaphylaxis, shoulder injuries related to vaccine administration (SIRVA) or brachial neuritis (Parsonage-Turner Syndrome) |
| Severe symptoms | Long-term pain, severe muscle stiffness and spasms |
| Prevention | Over-the-counter pain medication such as ibuprofen (Advil) or acetaminophen (Tylenol) |
| --- | --- |
| When to seek medical attention | If symptoms persist beyond a few days, or if there is bleeding, pain, redness or swelling that interferes with daily activities |
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What You'll Learn

Muscle pain and body aches are common side effects
While the tetanus shot is generally safe, it can cause various side effects, including muscle pain and body aches. These side effects are usually mild and not a cause for concern. They typically last only a few days and can be managed with over-the-counter pain medication. Other common side effects include pain, redness, and swelling at the injection site, fever, headache, and fatigue.
Serious side effects from the tetanus vaccine are rare but may occur in certain individuals. One such severe reaction is SIRVA (Shoulder Injury Related to Vaccine Administration), which can cause stiffness, impact your range of motion, and result in long-term pain. This occurs when the vaccine is administered too high or too deep in the shoulder, causing damage to the ligaments, tendons, and nerves.
In rare cases, the tetanus vaccine can also cause severe allergic reactions, such as anaphylaxis, which requires immediate medical attention. Other less common side effects include dizziness, nausea, and mild to moderate pain, redness, or swelling at the injection site.
It is important to note that most side effects from the tetanus vaccine are normal and will typically resolve on their own within a few days. However, if symptoms persist or become concerning, individuals should seek medical advice.
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Injection site pain, redness, and swelling
The injection site may feel tender, and you may experience redness or discolouration, and slight swelling for one to two days. These are normal, mild side effects that will go away on their own. However, if the injection site is bleeding, or the pain, redness, or swelling is severe and impacts your ability to perform daily activities, contact your doctor immediately.
Over-the-counter (OTC) pain medications such as ibuprofen can help alleviate discomfort. These medications are safe for adults but consult a doctor or pharmacist before giving them to children.
Serious side effects from the tetanus vaccine are rare. However, in rare cases, the vaccine can cause an allergic reaction, which may be severe and life-threatening (anaphylaxis). This typically occurs within a few minutes to an hour after vaccination and requires immediate medical attention.
Another rare but severe reaction is SIRVA (Shoulder Injury Related to Vaccine Administration). This can happen when the vaccine is administered too high or too deep in the shoulder, causing damage to ligaments, tendons, and nerves. SIRVA can result in long-term pain and, in the worst cases, permanent disability. If you experience any symptoms of SIRVA, seek immediate medical evaluation.
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Rare allergic reactions
While most people will not experience side effects after a tetanus shot, allergic reactions can occur in rare cases. These allergic reactions are typically severe and may be life-threatening. Anaphylaxis, a severe allergic reaction, can cause trouble breathing, an increased heart rate, and hives. This rare occurrence usually happens within minutes to a few hours after vaccination. Immediate treatment is crucial as the airways may close up, leading to fatal consequences.
People who have previously experienced severe allergic reactions to the tetanus vaccine should avoid subsequent doses. They can discuss alternative options with their doctors. Additionally, those who have had seizures, coma, or Guillain-Barré syndrome following a dose should consult a medical professional before receiving another vaccination.
In some instances, individuals may develop brachial neuritis or SIRVA (shoulder injury related to vaccine administration) after a tetanus shot. Brachial neuritis involves the immune system attacking the brachial plexus nerves, resulting in weakness, numbness, and severe pain in the affected arm. On the other hand, SIRVA is caused by improper vaccine administration, damaging ligaments, tendons, and nerves in the shoulder. It can lead to stiffness, restricted mobility, and pain in the shoulder.
While rare, severe allergic reactions to the tetanus vaccine can be life-threatening and require immediate medical attention. It is important to be aware of potential risks and consult a healthcare professional if any concerning symptoms develop following vaccination.
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Shoulder injury related to vaccine administration (SIRVA)
SIRVA can happen if a medical worker gives a vaccine shot too high up on the upper arm. The injury can occur during any vaccine administration and is often associated with TDaP shots. It usually occurs if the vaccine is administered too high or too deep in the shoulder. When this happens, it can cause damage to ligaments, tendons, and nerves.
The symptoms of SIRVA typically begin within 48 hours of vaccine administration and do not improve with over-the-counter analgesic medications. However, the symptoms can last for weeks, months, or even years. Affected individuals can experience varying degrees of disability, impacting their daily activities, social life, and emotional well-being.
If you suspect you may have SIRVA, it is important to seek medical attention. A GP, specialist, or allied health professional such as a physiotherapist can diagnose SIRVA based on presenting symptoms and clinical history. Radiological investigations such as ultrasound or MRI may be undertaken to support or confirm the diagnosis. Early diagnosis of SIRVA is crucial, as it can lead to timely treatment, lessening the duration and severity of symptoms. Treatment options for SIRVA may include over-the-counter pain or anti-inflammatory medications, and in severe cases, surgery may be required.
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Fatigue, fever, and headaches
Experiencing fatigue, fever, and headaches after receiving a tetanus shot is normal and usually nothing to worry about. These side effects are relatively common, and most will resolve without treatment.
Fatigue and drowsiness are common side effects of the tetanus vaccine. Feeling tired is a sign that your body and immune system are working hard to build immunity against the disease. This side effect typically lasts for a few days.
A mild fever is also a common side effect of the tetanus vaccine. A mild fever will usually go away within a day or so. However, if you experience a high fever or a fever that lasts longer than a few days, seek medical attention. To help reduce a mild fever, you can take over-the-counter medications such as acetaminophen (Tylenol) or ibuprofen.
Headaches are another common side effect of the tetanus vaccine. You may experience a mild to moderate headache for a few days after the shot. Taking a pain reliever such as ibuprofen or acetaminophen can help alleviate headache pain.
Serious side effects from the tetanus vaccine are very rare. However, in rare cases, the vaccine can cause severe allergic reactions, which may be life-threatening and require immediate medical attention. Other rare but serious side effects include neurological disorders such as Guillain-Barré Syndrome (GBS) and Brachial Neuritis, which can lead to long-term complications.
If you experience any unusual or persistent side effects after receiving the tetanus vaccine, it is always best to consult a healthcare professional.
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Frequently asked questions
Common side effects include pain, redness, swelling at the injection site, fever, headache, and fatigue. These side effects are usually mild and last only a few days.
Yes, muscle pain and body aches are possible side effects of the tetanus vaccine. They can occur within the first few days after vaccination and may last a few days.
Serious side effects of the tetanus shot are rare but can include severe allergic reactions, such as anaphylaxis, shoulder injuries related to vaccine administration (SIRVA), and brachial neuritis (Parsonage-Turner Syndrome).











































