
Keytruda is a medicine used to treat many types of cancer by working with the immune system to attack cancer cells. However, Keytruda may also cause the immune system to attack healthy tissues and organs, leading to inflammation in various parts of the body, including the muscles. This inflammation can result in muscle pain, which is a common side effect of the drug. In most cases, muscle pain from Keytruda is mild and manageable with over-the-counter pain relievers. However, it is important to consult a doctor if the pain becomes severe or if any other concerning side effects occur.
| Characteristics | Values |
|---|---|
| Inflammation in muscles | Yes |
| Inflammation in other body parts | Eyes, Brain, Bowel, Lungs, Intestines, Liver, Thyroid, Pituitary gland, Kidneys, Pancreas, Adrenal gland, Skin, Blood vessels, Nerves, Joints, Ovaries, Transplanted organs or tissues |
| Symptoms | Weight loss or gain, increased sweating or feeling cold, mood changes, heart rate changes, diarrhoea, constipation, abdominal pain, muscle pain, joint pain, back pain, Bone pain, hair loss, confusion, sleepiness, memory problems, balance problems, tingling or numbness of arms or legs, double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight, chest pain, fast or irregular heartbeat, weakness, swelling, stiffness, redness, vision loss, etc. |
| Inflammation due to | Overactive immune system |
| Treatment | Over-the-counter pain relievers, prescription pain medication, consulting an orthopedic (bone) specialist |
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What You'll Learn

Keytruda can cause inflammation in the eyes
Keytruda is a biologic drug used to treat many types of cancer in adults and certain children. It can be prescribed to treat melanoma and lung cancer, for example, non-small cell lung cancer. The drug is given by intravenous (IV) infusion, which is an injection into a vein over a period of time.
If you notice any eye or vision problems after starting Keytruda, it is important to seek medical advice immediately. Your doctor may refer you to an ophthalmologist, and you may need to stop Keytruda treatment.
Other serious side effects of Keytruda include severe skin reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be life-threatening and require immediate medical attention. Muscle or bone pain is another common side effect, which is usually mild and manageable with over-the-counter pain relievers. However, if the pain becomes severe, prescription medication or a referral to an orthopedic specialist may be necessary.
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It can cause inflammation in the brain
Keytruda is a medicine used to treat many types of cancer. It can cause inflammation in different parts of the body, including the brain. Encephalitis, or inflammation of the brain, is a rare but serious side effect of Keytruda. It can cause symptoms such as confusion, stiff neck, balance problems, and memory issues. If you experience any of these symptoms while taking Keytruda, it is important to seek medical attention immediately.
Keytruda works by activating the body's immune system to attack cancer cells. However, in some cases, it may cause the immune system to overreact, leading to severe immune system reactions. These reactions can result in the immune system attacking healthy tissues and organs, causing inflammation and damage. This is known as an immune-mediated side effect.
The inflammation caused by Keytruda can affect various parts of the body, including the muscles, joints, eyes, intestines, liver, lungs, thyroid, pituitary gland, kidneys, and pancreas. Symptoms of inflammation in these areas can include pain, swelling, stiffness, redness, vision problems, diarrhea, abdominal pain, nausea, vomiting, weight loss, and increased or decreased hormone levels.
It is important to note that the side effects of Keytruda can vary depending on whether it is used alone or in combination with other cancer drugs. Common side effects when Keytruda is used alone include muscle pain, fatigue, weight loss, fever, and decreased appetite. When used in combination with chemotherapy or radiation therapy, additional side effects may include hair loss, inflammation of the nerves, mouth sores, and joint and muscle pain.
If you are taking Keytruda or any other medication and experience side effects, it is important to consult your doctor or healthcare provider. They can provide guidance on managing side effects and determining if any adjustments to your treatment are necessary.
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It can cause inflammation in the lungs
Keytruda is a medicine used to treat many types of cancer. It can cause inflammation in various parts of the body, including the lungs. This is known as pneumonitis and can cause chest pain, shortness of breath, and a new or worsening cough. It is important to note that Keytruda can also cause other types of inflammation, such as colitis (inflammation of the bowel), hepatitis (inflammation of the liver), and encephalitis (inflammation of the brain).
The drug works by activating the body's immune system to attack cancer cells. However, in some cases, Keytruda may cause the immune system to attack normal organs and tissues, leading to inflammation and damage. This is known as an immune-mediated side effect and can occur during or after treatment. Serious immune system reactions can cause inflammation in the lungs and other organs, including the thyroid, pituitary gland, liver, kidneys, and pancreas.
Inflammation of the lungs can be life-threatening, so it is important to seek medical attention if you experience any symptoms such as chest pain, shortness of breath, or a persistent cough. Blood and urine tests may be required to diagnose pneumonitis and determine the extent of the inflammation. Treatment options may include medication to reduce inflammation and address any associated infections.
In addition to causing inflammation, Keytruda has various other side effects, including muscle or bone pain, fatigue, weight loss, fever, and diarrhoea. Some people may also experience hair loss, confusion, and eye-related issues such as uveitis and iritis. It is important to note that the side effects of Keytruda can vary depending on whether it is used alone or in combination with other cancer drugs.
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It can cause inflammation in the bowels
Keytruda is a medicine that may treat certain cancers by working with your immune system. It can cause your immune system to attack normal organs and tissues in any area of your body, leading to inflammation.
Inflammation in the bowels, also known as colitis, is a rare side effect of Keytruda, occurring in fewer than 1% of patients. It can cause diarrhoea, stomach pain, blood or mucus in your stool, or black, tarry stools. It is important to note that these symptoms can also be signs of other serious conditions, so if you experience any of them, you should seek medical advice as soon as possible.
Keytruda can also cause inflammation in other parts of the body, including the muscles, causing weakness and pain. This side effect tends to be mild and easily manageable in most cases, and can often be treated with over-the-counter pain relievers such as Tylenol (acetaminophen) or ibuprofen. If these remedies are not helpful, or if the pain becomes severe, it is important to consult a doctor, who may recommend prescription pain medication or refer you to an orthopedic specialist.
Other rare but serious side effects of Keytruda include encephalitis (inflammation of the brain), which may cause confusion, and severe skin reactions such as Stevens-Johnson syndrome, which can lead to death if not treated. It is important to be aware of these potential side effects and to seek medical advice if you experience any of them.
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It can cause inflammation in the thyroid
Keytruda is a biologic drug used to treat many kinds of cancer in both adults and children. Its active ingredient, pembrolizumab, is administered by intravenous (IV) infusion.
Keytruda can cause serious side effects due to an overactive immune system. These are called immune-mediated side effects, and they often cause inflammation (damage and swelling of body tissues). For example, Keytruda can cause encephalitis (inflammation of the brain) which may lead to confusion.
Keytruda can also cause inflammation in the thyroid. Thyroiditis, or inflammation of the thyroid, is most commonly caused by antibodies that attack the thyroid. This can cause a short period of hyperthyroidism followed by hypothyroidism. Symptoms of thyroid gland inflammation can include weight loss or gain, increased sweating or feeling cold, mood changes, and heart rate changes. Diarrhea and constipation are also possible symptoms.
Hair loss could be a sign that Keytruda is causing inflammation of the thyroid gland. However, hair loss is a very common side effect of many cancer treatments and usually goes away when treatment ends. Nevertheless, you should always tell your doctor if you are losing your hair, especially if you are receiving Keytruda without chemotherapy or are experiencing other symptoms of thyroid inflammation.
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Frequently asked questions
Keytruda is a medicine that may treat certain cancers by working with your immune system.
Yes, Keytruda can cause inflammation in the muscles, which may lead to pain, weakness, and stiffness.
Muscle or bone pain from Keytruda is usually mild and manageable. Over-the-counter pain relievers such as Tylenol (acetaminophen) may help, but be sure to consult your doctor before taking any medication. If the pain becomes severe, your doctor may recommend prescription pain medication or refer you to an orthopedic specialist.











































