
Lamotrigine is a medication used to treat epilepsy and bipolar disorder. It works by calming overactive nerves in the body. Like all medicines, lamotrigine can cause side effects, although not everyone experiences them. Some of the common side effects of lamotrigine include weight changes, skin rash, blurred vision, dizziness, drowsiness, and dry mouth. Rare side effects, occurring in less than 0.1% of cases, include muscle spasms, neuralgia, and peripheral neuritis. Very rarely, occurring in less than 0.01% of cases, lamotrigine may cause muscle spasms, paralysis, and peripheral neuritis. It is important to consult a doctor or pharmacist if you are concerned about any side effects.
| Characteristics | Values |
|---|---|
| Can lamotrigine cause muscle spasms? | Yes, muscle spasms are a rare side effect of lamotrigine, occurring in less than 0.1% of cases. |
| What is lamotrigine? | Lamotrigine is a medication that treats epilepsy by preventing and controlling seizures. It can also treat bipolar disorder. |
| How does it work? | It works by calming overactive nerves in the body. |
| What are the common side effects? | Common side effects include weight gain or weight loss, skin rash, blurred vision, double vision, clumsiness, unsteadiness, dizziness, drowsiness, and flu-like symptoms. |
| Are there any serious side effects? | Serious side effects may include allergic reactions affecting multiple organs, heart rhythm problems, and suicidal thoughts or tendencies. Rare but serious side effects include life-threatening rashes, Stevens-Johnson syndrome, and toxic epidermal necrolysis. |
| What should I do if I experience side effects? | If you experience any side effects, speak to your pharmacist or doctor. Do not stop taking lamotrigine without first checking with your doctor, as stopping suddenly can increase seizures or their severity. |
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What You'll Learn
- Lamotrigine is a medication that treats epilepsy and bipolar disorder
- It can cause serious allergic reactions and affect multiple body organs
- It may cause muscle spasms, but this is rare
- It can increase the effects of alcohol and central nervous system (CNS) depressants
- It may cause serious skin reactions

Lamotrigine is a medication that treats epilepsy and bipolar disorder
Lamotrigine is an anti-seizure medication used to treat epilepsy and bipolar disorder. It works by calming overactive nerves in the body. The medication is available under the brand names Lamictal and Subvenite.
Lamotrigine is used to prevent and control seizures in people with epilepsy. It is also used to treat bipolar I disorder maintenance and Lennox-Gastaut syndrome. Additionally, it has off-label uses, including treating acute bipolar depression, fibromyalgia, schizophrenia, and unipolar depression.
When starting treatment with lamotrigine, it is important to adjust the dose slowly. It may take weeks or months before a stable dose is achieved. It is crucial not to stop taking this medication without first consulting a doctor, as doing so can increase the frequency and severity of seizures.
Like all medicines, lamotrigine can cause side effects, although not everyone experiences them. Some common side effects include flu-like symptoms, skin rash, blurred vision, double vision, clumsiness, unsteadiness, dizziness, drowsiness, and dry mouth. Serious allergic reactions affecting multiple organs, such as the liver or kidney, may occur in rare cases. It is important to seek medical advice if any side effects occur and to report any changes in mood or behaviour to the care team.
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It can cause serious allergic reactions and affect multiple body organs
Like all medicines, lamotrigine can cause side effects, although not everyone experiences them. While serious reactions are rare, lamotrigine can cause serious allergic reactions and affect multiple body organs.
Lamotrigine can cause flu-like symptoms, followed by a red or purple rash that spreads and forms blisters. The affected skin eventually dies and peels off. This is known as Stevens-Johnson syndrome, a rare but serious side effect of lamotrigine. It can be life-threatening and may require hospital treatment. It is more likely to occur in the first eight weeks of starting the medication or when the dose is increased too quickly.
Lamotrigine has also been associated with osteoporosis and osteopenia in long-term users, increasing the risk of breaking bones. In addition, it may cause serious allergic reactions, although such cases are rare. Symptoms of a serious allergic reaction include sudden swelling of the lips, mouth, throat, or tongue, rapid breathing or difficulty breathing, a tight throat, and changes in skin, tongue, or lip colour. These symptoms require immediate medical attention and hospital treatment.
Furthermore, lamotrigine may cause side effects that indicate problems with multiple body organs. For example, it can lead to dark urine, yellow eyes or skin (jaundice), nausea, vomiting, and stomach pain, which may suggest liver or kidney issues. Other symptoms such as fever, headache, stiff neck, and sensitivity to light could indicate meningitis. It is crucial to consult a doctor immediately if any of these symptoms occur.
While rare, lamotrigine may also cause muscle spasms, as well as other neurological symptoms such as dystonia, neuralgia, and peripheral neuritis. It is important to be aware of these potential side effects and consult a doctor if any symptoms develop, as they can provide advice and adjust the dosage or medication if needed.
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It may cause muscle spasms, but this is rare
Like all medicines, lamotrigine can cause side effects, but not everyone experiences them. Lamotrigine is a medication that treats epilepsy by preventing and controlling seizures. It can also treat bipolar disorder. It works by calming overactive nerves in your body.
Lamotrigine may cause muscle spasms, but this is rare. Rare side effects (less than 0.1%) of lamotrigine include choreoathetosis, dystonia, extrapyramidal syndrome, faintness, grand mal seizures, hemiplegia, hyperalgesia, hyperesthesia, hypokinesia, hypotonia, neuralgia, paralysis, peripheral neuritis, and muscle spasms. Very rare side effects (less than 0.01%) include muscle spasms, paralysis, and peripheral neuritis.
In addition to muscle spasms, lamotrigine may also cause blurred vision, double vision, clumsiness, unsteadiness, dizziness, drowsiness, and dry mouth. It may also cause serious allergic reactions affecting multiple body organs, such as the liver or kidney. Check with your doctor right away if you experience fever, dark urine, headache, hives, muscle pain or stiffness, stomach pain, unusual tiredness, or yellow eyes or skin.
Lamotrigine can also cause some unpredictable side effects no matter the dose, and these can happen at any time. Serious skin reactions are also possible, and these can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin.
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It can increase the effects of alcohol and central nervous system (CNS) depressants
Lamotrigine is a medication used to treat epilepsy and bipolar disorder. It works by calming overactive nerves in the body. While it is a relatively safe drug, it can cause side effects, including muscle spasms.
Lamotrigine may increase the effects of alcohol and central nervous system (CNS) depressants. CNS depressants are medicines that make you drowsy or less alert. These include antihistamines, medicines for allergies or colds, sedatives, tranquilizers, sleeping medicine, prescription pain medicine, narcotics, medicine for seizures, barbiturates, muscle relaxants, and anesthetics (including some dental anesthetics).
The combination of lamotrigine and alcohol or CNS depressants can enhance the effects of these substances, leading to increased drowsiness, dizziness, blurred vision, double vision, clumsiness, and unsteadiness. It is important to consult a doctor before consuming alcohol or taking any CNS depressants while using lamotrigine.
Additionally, lamotrigine may cause other side effects, such as skin rash, flu-like symptoms, fever, dark urine, headache, hives, muscle pain or stiffness, stomach pain, unusual tiredness, and yellow eyes or skin. Some people may experience agitation, irritability, abnormal behaviors, suicidal thoughts, or depression. It is crucial to seek medical advice if any of these side effects occur.
It is important to note that the presence of other medical conditions, such as heart rhythm problems or liver disease, may impact the use of lamotrigine. It is always advisable to consult a healthcare professional and follow their instructions when taking this medication.
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It may cause serious skin reactions
Lamotrigine is a medication that treats epilepsy and bipolar disorder. It works by calming overactive nerves in the body. However, like all medicines, it can cause side effects, although not everyone experiences them.
One such side effect is serious skin reactions. These can happen weeks or months after starting the medication. Contact your doctor or care team right away if you notice any of the following:
- Fever or flu-like symptoms with a rash
- A red or purple rash that spreads and forms blisters, eventually peeling off
- A red rash with swelling of the face, lips, or lymph nodes in the neck or underarms
- Skin rash, itching, hives, or swelling of the face, lips, tongue, or throat
If you are experiencing any of these symptoms, do not drive, use machinery, or do anything that requires mental alertness until you know how this medication affects you.
If you are concerned about any side effects, speak to your pharmacist or doctor.
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Frequently asked questions
Lamotrigine is a medication that treats epilepsy by preventing and controlling seizures. It can also treat bipolar disorder. It works by calming overactive nerves in your body.
Muscle spasms are a rare side effect of Lamotrigine, occurring in less than 0.1% of patients. However, muscle pain and stiffness are more common side effects, affecting more than 1 in 10 people.
If you experience any side effects that are bothersome or concerning, you should speak to your doctor or pharmacist. They can help answer any questions and make adjustments to your medication if necessary.


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