
Lexapro is a potent antidepressant and anti-anxiety medication that works by regulating serotonin levels in the brain. While it is an effective drug for treating major depressive disorder and generalized anxiety disorder, it can cause a range of side effects, including muscle stiffness. This side effect is uncommon, affecting 0.1% to 1% of patients. Muscle stiffness can be a symptom of serotonin syndrome, a dangerous complication caused by excessive serotonin levels in the body. It is important to be aware of the potential side effects of Lexapro, including muscle stiffness, and to seek medical advice if any adverse reactions occur.
| Characteristics | Values |
|---|---|
| Muscle stiffness | Uncommon (0.1% to 1%) |
| Lexapro Side Effects | Nausea, dizziness, suicidal thoughts, depression, anxiety, difficulty sleeping, drowsiness, headaches, restlessness, fatigue, nervousness, dry mouth, sweating, agitation, hallucinations, confusion, coma, coordination problems, overactive reflexes, racing heart rate, high or low blood pressure, fever, vomiting, diarrhea, seizures, low salt levels, weakness, unsteadiness, bleeding, sexual problems, heart rhythm changes, abnormal bleeding, constipation, tiredness, joint pain, teeth grinding, glaucoma, coughing up blood, blood in urine, black or red poo, blood in vomit, bruising, painful erections, weight change, appetite change, allergic reactions, withdrawal symptoms |
| Lexapro Precautions | Do not take with alcohol or illicit drugs, do not stop taking without consulting a doctor, do not mix with aspirin, clonazepam, levothyroxine, lisinopril, metformin, NSAIDs, warfarin, ibuprofen, naproxen, St. John's wort, ginseng, lithium, other antidepressants |
| Lexapro Dosage | 10mg is the usual dose, can vary from 10mg to 20mg depending on medical condition and response to the drug, should be taken exactly as prescribed by the doctor |
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What You'll Learn

Lexapro and serotonin syndrome
Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) that is used to treat anxiety and depression. It works by increasing serotonin levels in the brain. Serotonin is a chemical that the body produces naturally and is needed for nerve cells and the brain to function.
Serotonin syndrome is a serious drug reaction caused by medications that build up high levels of serotonin in the body. This condition can be life-threatening and requires immediate medical attention. It can occur when you increase the dosage of certain medications, start taking a new drug, or combine medications that contain serotonin. For example, serotonin syndrome may occur if you take an antidepressant with a migraine medication or an opioid pain medication.
Lexapro has been associated with serotonin syndrome in some cases. It can cause serotonin syndrome when taken alone or with other medications that affect serotonin. Symptoms of serotonin syndrome can range from mild to severe and include:
- Agitation
- Hallucinations
- Loss of consciousness
- Coordination problems
- Overactive reflexes
- Racing heart rate
- High or low blood pressure
- Sweating or fever
- Nausea, vomiting, or diarrhea
- Muscle stiffness or rigidity
- Seizures
If you suspect serotonin syndrome after starting or adjusting the dosage of Lexapro, it is crucial to seek medical advice immediately. Mild forms of serotonin syndrome may resolve within a few days of discontinuing the medication, but severe cases can be fatal if left untreated.
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Muscle stiffness and spasms
Lexapro is a prescription drug used to treat anxiety and depression. It is a selective serotonin reuptake inhibitor (SSRI) that works by blocking the reuptake of serotonin, making more of the neurotransmitter available in the brain. While Lexapro can be effective in treating these conditions, it may also cause various side effects, some of which are mild, while others are more severe.
In addition to muscle stiffness and spasms, Lexapro may also cause other physical side effects, such as nausea, dizziness, diarrhoea, dry mouth, fatigue, and joint pain. It can also lead to low sodium levels in the blood, resulting in symptoms such as headaches, confusion, and weakness. In rare cases, Lexapro may cause serotonin syndrome, a condition characterised by excessive serotonin levels in the body, which can lead to muscle twitching, stiffness, and tremors, among other symptoms.
If you experience any side effects while taking Lexapro, it is important to consult your doctor or healthcare provider. They may advise adjusting the dosage or provide recommendations to help manage the side effects. It is generally advised not to stop taking Lexapro abruptly, as this can lead to withdrawal symptoms. Instead, gradual tapering of the medication under medical supervision is recommended to minimise the risk of withdrawal effects.
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Lexapro side effects in the first week
Lexapro (escitalopram) is an antidepressant medication that belongs to the class of drugs called selective serotonin reuptake inhibitors (SSRIs). It is commonly prescribed to treat symptoms of clinical depression and anxiety in people aged 12 and older. While it is generally well-tolerated, it can cause side effects, especially during the first week of use. These side effects are typically mild at lower doses, and many people have no side effects or only minor ones. Here is what you should know about Lexapro side effects during the first week:
Common Side Effects in the First Week:
- Nausea
- Diarrhea
- Difficulty sleeping or drowsiness
- Increased energy
- Agitation or restlessness
- Upset stomach or vomiting
- Dizziness
- Dry mouth
- Increased sweating
- Irritability
- Muscle cramps, twitching, or stiffness
- Headaches
- Sexual side effects
Serious but Uncommon Side Effects:
- Serotonin syndrome: This rare but potentially life-threatening condition can occur when there is too much serotonin in the body. Symptoms include severe muscle tightness, fever, seizures, and confusion.
- Suicidal thoughts or worsening depression: Lexapro may increase the risk of suicidal thinking and behaviour, especially in children, teens, and young adults. It can also worsen existing depression.
- Low salt levels (hyponatremia): This is more common in seniors, people taking water pills, or those who are dehydrated. Symptoms include headaches, confusion, weakness, unsteadiness, and seizures.
- Allergic reaction: Symptoms may include difficulty breathing, rash, or swelling of the face, tongue, eyes, or mouth.
It's important to note that side effects typically start to subside after the first one to two weeks of taking Lexapro, and it may take four to six weeks to fully adjust to the medication and feel its full effects. If any side effects persist or negatively impact your life, be sure to talk to your doctor, as they may recommend adjusting the dose or trying another medication.
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Lexapro withdrawal symptoms
Lexapro (escitalopram) is a prescription drug used to treat anxiety and depression. It belongs to the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). While it can be highly effective, caution is advised when discontinuing its use.
Stopping Lexapro or any medication abruptly can lead to severe withdrawal symptoms and health complications. This is known as Antidepressant Discontinuation Syndrome (ADS), which can cause a variety of symptoms, including:
- Insomnia
- Nausea
- Fatigue
- Aches and pains
- Flu-like symptoms
- Emotional changes
- Suicidal thoughts
- Increased energy
- Agitation
- Hallucinations
- Confusion
- Memory problems
- Weakness
- Seizures
- Low salt levels in the body
The first signs of Lexapro withdrawal typically appear one to three days after the last dose but can vary from a few hours to over a week. Symptoms generally last from one week to several months and tend to peak around day five. In most cases, they resolve within two weeks but may persist for up to eight weeks or longer in rare cases.
To minimise withdrawal symptoms, it is crucial to gradually taper off Lexapro under medical supervision. This involves slowly lowering the dosage over time, allowing the body to adjust to lower levels of the medication.
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Lexapro and low sodium levels
Lexapro (escitalopram) is a prescription drug used to treat anxiety and depression. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). While it can be effective, like all medicines, it may cause side effects in some people.
Lexapro may cause low salt (sodium) levels in the body, known as hyponatremia. This side effect is more likely to occur in seniors, people taking water pills, or those who are dehydrated. Low sodium levels can cause symptoms such as headaches, confusion, trouble concentrating, memory problems, weakness, and unsteadiness that may lead to falls. In severe cases, hyponatremia can be potentially fatal, especially when left untreated.
The risk of hyponatremia is typically highest during the initial weeks of treatment with Lexapro and is more common in women, patients aged 65 years or older, and those taking multiple medications that can cause hyponatremia. In most reported cases, serum sodium levels returned to normal within a few days to a few weeks after discontinuing Lexapro and, if necessary, receiving appropriate medical treatment.
It is important to monitor for any signs or symptoms of low sodium levels while taking Lexapro. If you experience any side effects, consult your doctor or healthcare provider, who may adjust your dosage or recommend alternative treatments.
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Frequently asked questions
Yes, muscle stiffness is a known side effect of Lexapro.
Lexapro (escitalopram) is a prescription drug used to treat anxiety and depression. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Common side effects of Lexapro include nausea, dizziness, anxiety, difficulty sleeping, drowsiness, headaches, dry mouth, sweating, fatigue, nervousness, and diarrhea. More severe side effects may include suicidal thoughts, seizures, and serotonin syndrome.
Serotonin syndrome occurs when there is too much serotonin in the body. Symptoms can include agitation, hallucinations, confusion, racing heartbeat, high or low blood pressure, sweating, fever, nausea, vomiting, and muscle twitching or stiffness. Serotonin syndrome can be life-threatening and requires immediate medical attention.
Yes, it is important to consult a doctor before taking Lexapro, especially if you have a history of mental health issues or are taking other medications. Lexapro may interact with certain drugs, including aspirin, NSAIDs, and antidepressants. It is also recommended to avoid alcohol and illicit drugs while taking Lexapro.

















