
Fluvoxamine, sold under the brand name Luvox, is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat social anxiety disorder, obsessive-compulsive disorder, and other conditions as determined by a healthcare provider. While Luvox can be an effective treatment option, it is important to be aware of its potential side effects, which can vary from person to person. One of the reported side effects of Luvox is muscle-related issues, including muscle stiffness, muscle twitching, muscle jerking, muscle spasms, and uncontrolled movements. Back pain, bone fractures, leg cramps, and muscular weakness have also been reported, although the frequency of these occurrences is not well-documented.
| Characteristics | Values |
|---|---|
| Muscle-related side effects | Muscle twitching, jerking, spasms, tremors, or other uncontrolled movements, severe muscle stiffness, myasthenia, neck pain, neck rigidity, muscular weakness, rhabdomyolysis, muscle control issues |
| Other side effects | Agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, loss of coordination, nausea, vomiting, diarrhea, blurred vision, drowsiness, poor judgment, increased risk of bleeding, weight loss, sexual problems, glaucoma, low sodium levels |
| Risk factors | Children, teenagers, and young adults may experience suicidal thoughts and tendencies or become more depressed. Pregnant women may cause problems in newborns following delivery if taken during the last months of pregnancy. |
| Drug interactions | Buspirone (Buspar), fentanyl (Abstral, Duragesic), lithium (Eskalith, Lithobid), tryptophan, St. John's wort, amphetamines, pain or migraine medicines (e.g., meperidine, methadone, rizatriptan, sumatriptan, tramadol), aspirin, NSAIDs (e.g., ibuprofen, naproxen), blood thinners (e.g., warfarin), alcohol |
What You'll Learn

Muscle spasms and twitching
Fluvoxamine, sold under the brand name Luvox, is an antidepressant that belongs to a group of medicines called selective serotonin reuptake inhibitors (SSRIs). It is commonly used to treat obsessive-compulsive disorder (OCD) and social anxiety disorder. While it can be effective for these conditions, it may also cause several side effects, including muscle spasms and twitching.
In the context of Luvox usage, muscle spasms and twitching can be attributed to several factors. One of the primary causes may be the alteration of serotonin levels in the brain, as SSRIs like Luvox work by increasing serotonin concentrations. Serotonin plays a role in muscle function, and changes in serotonin levels can lead to abnormal muscle contractions and relaxation, resulting in spasms and twitching.
Additionally, Luvox may interact with other medications and substances, increasing the likelihood of muscle spasms and twitching. For example, it can interact with certain pain medications, migraine treatments, and muscle relaxers. These interactions can heighten the risk of muscle-related side effects. Furthermore, Luvox may also cause drowsiness and affect an individual's judgment, thinking, or motor skills. These factors can indirectly contribute to muscle spasms and twitching, especially if an individual engages in strenuous physical activity or experiences muscle fatigue due to decreased alertness.
It is important to consult a healthcare professional if you experience muscle spasms or twitching while taking Luvox. They may advise adjusting the dosage or provide recommendations to mitigate these side effects. Additionally, do not abruptly discontinue Luvox without consulting your doctor, as this can lead to withdrawal symptoms, including muscle-related issues.
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Risk of bleeding problems
While Luvox (fluvoxamine) is a prescription drug used to treat obsessive-compulsive disorder and social anxiety disorder, it may increase your risk of bleeding problems. This risk is heightened if you are taking other medicines that thin the blood, including aspirin, NSAIDs (e.g. ibuprofen, naproxen), or warfarin. Luvox may also interact with other drugs, such as buspirone, fentanyl, lithium, tryptophan, St. John's wort, amphetamines, and some pain or migraine medications. It is important to consult your doctor before taking any other medications with Luvox, and to be aware of the signs of serotonin syndrome, a life-threatening condition caused by a buildup of serotonin in the body.
If you are taking Luvox, it is important to be vigilant about any changes in how easily you bruise or bleed, and to inform your doctor if you notice any such changes. This includes any unusual bleeding or bruising that occurs during surgery, including dental surgery. It is also important to inform your doctor if you are pregnant, especially during the last few months, as Luvox may cause problems in newborns following delivery.
Additionally, Luvox may cause some people to become drowsy, less able to think clearly, or experience blurred vision or poor muscle control. It is advised that you do not drive or operate machinery until you know how this medication affects you. Alcohol should also be avoided while taking Luvox, as it can enhance the medication's drowsiness effects.
It is important to gradually reduce the dosage under the supervision of a doctor before stopping Luvox completely to decrease the chance of experiencing withdrawal symptoms, which may include agitation, confusion, headache, irritability, numbness, restlessness, and unusual drowsiness or weakness.
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Suicidal thoughts and tendencies
Fluvoxamine, sold under the brand name Luvox, is an antidepressant medication that comes in tablet form. It is primarily used to treat obsessive-compulsive disorder (OCD) and depression. It is also sometimes prescribed for other conditions as determined by a healthcare provider.
Fluvoxamine may cause some people to experience suicidal thoughts and tendencies, especially during the first few months of treatment or during dose adjustments. This risk is higher in children, teenagers, and young adults up to 24 years of age. However, it is important to note that short-term studies did not show an increase in the risk of suicidality compared to a placebo in adults beyond the age of 24, and there was a reduction in risk in adults aged 65 and older.
If you or your child are experiencing suicidal thoughts or tendencies while taking fluvoxamine, it is important to seek medical help right away. Call your doctor or healthcare provider immediately and follow their instructions. In case of an emergency or if someone is about to harm themselves, call 911 or the Suicide & Crisis Lifeline at 988.
It is also important to monitor patients of all ages who are started on antidepressant therapy, including fluvoxamine, for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised to communicate any concerns to the prescriber and stay in close contact with the treatment team.
In addition to the risk of suicidal thoughts and tendencies, fluvoxamine may cause other side effects, such as muscle twitching, jerking, spasms, or other uncontrolled movements. It can also increase the risk of acute angle-closure glaucoma, which can lead to blurred vision, red and painful eyes, headache, nausea, and vomiting. Certain medications, such as aspirin and blood thinners, may increase the risk of bleeding occurrences when taken with fluvoxamine. Therefore, it is crucial to discuss all medications and supplements you are taking with your doctor before starting fluvoxamine.
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Sexual problems
While muscle pain is not listed as a side effect of taking Luvox (fluvoxamine), the medication does carry a risk of causing muscle stiffness or twitching. Fluvoxamine is an antidepressant that belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs).
Sexual dysfunction is a recognised side effect of SSRIs, including fluvoxamine. Sexual dysfunction is defined by the World Health Organization (WHO) as "the various ways in which an individual is unable to participate in a sexual relationship as he or she would wish". This can include changes in sexual drive, arousal, penile erection or vaginal lubrication, ability to reach orgasm, and satisfaction with orgasm.
Sexual side effects from SSRIs may subside over time, so it is worth waiting a while to see if the problems diminish, especially if the medication is easing your depression significantly. If the sexual side effects persist, you should talk to your doctor or therapist, who may suggest one of the following strategies:
- Lower the dose: Sexual side effects may subside at a lower, yet still therapeutic, dose.
- Schedule sex: SSRIs may produce more pronounced side effects at particular times of the day, such as within a few hours of taking the medication. If this is the case, you can try scheduling sexual activity for when side effects are least bothersome, or take the drug at a different time.
- Switch to a different drug: Certain antidepressants, such as bupropion (Wellbutrin) and mirtazapine (Remeron), are less likely to cause sexual problems.
- Add a drug: For some men, taking sildenafil (Viagra) or tadalafil (Cialis) can alleviate SSRI-induced erectile dysfunction. Both men and women may benefit from adding bupropion to their treatment, as it has been found to counter SSRI-induced sexual dysfunction and boost sexual drive and arousal.
- Meet with a therapist: Even when physical issues or medication are at the root of sexual problems, psychological issues often become interwoven.
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Withdrawal symptoms
Fluvoxamine, sold under the brand name Luvox, is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat social anxiety disorder and obsessive-compulsive disorder. It is also sometimes used to treat depression.
As with any medication, it is important not to stop taking fluvoxamine (Luvox) without first consulting your doctor. They may recommend gradually reducing the dosage before stopping completely to reduce the risk of withdrawal symptoms.
- Agitation
- Confusion
- Headache
- Irritability
- Numbness or tingling
- Restlessness
- Trouble sleeping
- Unusual drowsiness or weakness
- Dizziness
- Extreme worry or uneasiness
- Mood changes
- Pain, burning, or electric shock sensations in the hands or feet
It is important to note that the risk of experiencing withdrawal symptoms varies from person to person, and that not everyone will experience all of the symptoms listed above. If you are concerned about potential withdrawal symptoms or plan to discontinue fluvoxamine (Luvox), consult your healthcare provider for personalized advice and guidance.
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Frequently asked questions
Yes, Luvox may cause muscle pain, stiffness, spasms, and twitching.
Luvox, or fluvoxamine, is a selective serotonin reuptake inhibitor (SSRI) and antidepressant used to treat social anxiety disorder and obsessive-compulsive disorder.
Common side effects of Luvox include drowsiness, blurred vision, poor muscle control, agitation, and increased risk of bleeding. Rare side effects include severe muscle stiffness, nausea, vomiting, diarrhoea, and fever.
Do not stop taking Luvox without first consulting your doctor. Withdrawal symptoms may include agitation, confusion, headache, irritability, and dizziness.
Luvox should not be taken with buspirone, fentanyl, lithium, tryptophan, St. John's wort, amphetamines, or some pain or migraine medications. Always consult your doctor before taking any other medications with Luvox.



