
Blood thinners are medications that help prevent blood clots, which can cause heart attacks or strokes. While they are beneficial in this regard, they also come with certain side effects, the most common and worrisome one being an increased risk of bleeding. Other side effects of blood thinners include bruising more easily, nausea, anemia, hemorrhage, thrombocytopenia, and an increased risk of clotting in the spine or epidural area, which may lead to paralysis. This raises the question: do blood thinners also cause muscle cramps?
| Characteristics | Values |
|---|---|
| Muscle Cramps | Unclear, but Eliquis (a blood thinner) may cause muscle spasms in 1-10% of patients |
| Cause of Muscle Cramps | Unclear, but could be related to the medication's effect on blood flow and clotting |
| Other Common Side Effects | Bleeding, bruising, anemia, hemorrhage, nausea, back pain, pain in extremity, osteoarthritis, musculoskeletal pain, myalgia, arthritis |
| Serious Side Effects | Anaphylaxis, necrosis, internal bleeding, increased risk of stroke after stopping medication, paralysis |
| Risk Factors | Taking other medications or supplements, pregnancy, history of bleeding problems, playing risky sports |
| Precautions | Take as directed, inform doctors and dentists, avoid daily tasks that could cause injury, use caution with herbal supplements and teas, avoid grapefruit and cranberry juice |
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What You'll Learn

Blood thinners and herbal supplements
Blood thinners are medications that prevent blood clots from forming or growing larger, reducing the risk of heart attack or stroke. They can be taken by mouth, injection, or IV, and it is important to take them exactly as prescribed to prevent serious side effects, especially bleeding.
Herbal supplements and teas can interact with blood thinners and affect their efficacy, so it is important to inform your doctor about any supplements you are taking. Several herbs, such as garlic, ginger, ginkgo, and cinnamon, have anticoagulant properties and can increase the risk of bleeding. Cranberry juice and alcoholic beverages should also be avoided when taking blood thinners as they can contribute to the development of side effects.
Some supplements, like fish oil, melatonin, and ginkgo, are not regulated by the FDA like prescription drugs but can still have powerful effects on the body. For example, warfarin, a commonly prescribed blood thinner, is derived from coumarin, a compound found in cinnamon. Consuming cinnamon may support the action of warfarin, but more research is needed.
Evening primrose oil has been shown to slow the clotting process and stop platelets from sticking together, which may increase bleeding during and after surgery. Dong quai, a supplement containing compounds derived from coumarin, has been shown to worsen bleeding in people taking warfarin.
It is important to discuss any herbal supplements with your doctor before taking them, especially if you are already taking prescription blood thinners.
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Risk of bleeding
Blood thinners are medications that help prevent blood clots, which can cause heart attacks, strokes, or other types of heart disease. While these medications can be lifesaving, they also come with risks, the most worrisome being the increased risk of bleeding. This is because blood thinners make your blood harder to clot, so even a small cut or injury can lead to excessive bleeding. The risk of bleeding depends on the specific blood thinner being used. For example, warfarin has a much higher risk of causing bleeding compared to other blood thinners as it requires a precise dosage. People taking warfarin have a 0.4% to 7.2% risk of major bleeding and up to a 15% chance of minor bleeding. On the other hand, newer oral anticoagulants carry a lower risk of bleeding.
It is crucial to take blood thinners exactly as prescribed to prevent serious side effects. Taking too much can lead to severe bleeding. Additionally, certain medications, supplements, and herbal products can interfere with blood thinners, increasing the risk of bleeding. These include aspirin, antibiotics, antifungal drugs, blood pressure medications, antidepressants, and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen. Alcoholic beverages and cranberry juice can also contribute to the development of side effects when taking blood thinners. Therefore, it is essential to inform your doctor about any other medications or supplements you are taking, even over-the-counter ones, to ensure your safety.
While on blood thinners, it is important to take precautions to avoid injuries that could lead to bleeding. This includes using knives, scissors, and yard equipment with caution and protecting yourself during physical activities. Inform your dentist that you are taking blood thinners to prevent excessive bleeding during dental procedures. If you experience any unusual bleeding, such as bruising or bleeding that lasts a long time, seek medical attention immediately.
In summary, while blood thinners are effective in preventing blood clots, they also carry a risk of bleeding, which can be severe in certain cases. It is important to carefully follow the instructions provided by your doctor and be vigilant about potential interactions with other substances to minimize the risk of bleeding while taking blood thinners.
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Exercise and physical activity
Exercise is essential for your health and can help avoid complications from many conditions that blood thinners treat. However, it is important to take some precautions. Since blood thinners increase the risk of severe bleeding, it is recommended to avoid high-impact or injury-prone activities, such as hockey, soccer, skiing, skateboarding, football, wrestling, boxing, gymnastics, and ice skating.
If you are taking blood thinners, it is important to consult with your doctor before engaging in any new form of physical activity. Low-intensity physical activity like walking is a great place to start. Start with a few minutes at a time and gradually increase the duration. It is also important to wear comfortable clothing and well-fitting shoes to prevent injury.
Swimming, jogging, and bike riding are also considered safe forms of exercise for people taking blood thinners. When riding a bike, it is crucial to wear a helmet to protect your head. Additionally, gentle stretching, yoga, and strength training can help improve flexibility, muscle tone, and balance. Proper form is essential to prevent injury, especially when lifting weights.
While exercising, it is important to stay hydrated and stretch regularly. It is also recommended to discuss your diet, lifestyle activities, and any other medications you are taking with your doctor to ensure a safe and effective treatment plan.
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Eliquis side effects
Eliquis (apixaban) is a prescription medicine used to treat blood clots in the veins of the legs (deep vein thrombosis-DVT) or lungs (pulmonary embolism-PE). It is also used to reduce the risk of strokes in people with atrial fibrillation, a type of irregular heartbeat. Eliquis is also used in children to treat blood clots after initial anticoagulant treatment.
As a blood thinner, Eliquis may cause several side effects, the most common being bleeding. Since Eliquis thins the blood, it makes the blood harder to clot, which can lead to excessive bleeding from injuries, cuts, or bruises. This bleeding can be serious and may even lead to death in rare cases. People taking Eliquis may also experience heavier bleeding from regular teeth cleanings, so it is important to inform your dentist if you are taking this medication.
Other common side effects of Eliquis include tiredness, weakness, dizziness, and skin pallor, which could be signs of anaemia. If you experience any of these symptoms, you should consult your doctor.
Less common but serious side effects of Eliquis include severe allergic reactions, which can be life-threatening. If you experience any symptoms of a severe allergic reaction, such as swelling of the lips, mouth, throat, or tongue, or difficulty breathing, you should seek immediate medical attention.
It is important to take Eliquis exactly as prescribed by your healthcare provider and to inform them of any other medications or supplements you are taking, as these may increase the risk of bleeding.
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Warfarin side effects
Warfarin is an anticoagulant or blood thinner that decreases the clotting ability of the blood. It is available only with a doctor's prescription. Doctors will carefully monitor the dosage and may occasionally run a prothrombin time (PT) test to measure the international normalized ratio (INR) or the rate at which your blood clots.
The most common side effect of warfarin is bleeding. This is because, while taking warfarin, your blood will not clot as easily. People taking warfarin have anywhere from a 0.4% to 7.2% risk of major bleeding and up to a 15% chance of a minor bleed. This type of bleeding is usually not dangerous and should stop by itself. However, if it does not stop, you should inform your doctor.
In rare cases, warfarin can cause a serious allergic reaction (anaphylaxis). Symptoms of an allergic reaction include sudden swelling of the lips, mouth, throat, or tongue, breathing difficulties, skin, tongue, or lips turning blue, grey, or pale, and dizziness.
Other side effects of warfarin include skin necrosis or gangrene. It is also important to note that pregnant women should avoid taking warfarin as it can harm the unborn baby.
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Frequently asked questions
Muscle spasms and musculoskeletal pain are listed as side effects of the blood thinner Eliquis (apixaban). However, it is unclear whether these side effects are specifically related to muscle cramps. It is important to consult a doctor or healthcare provider if you experience any side effects from taking blood thinners.
Common side effects of blood thinners include an increased risk of bleeding, bruising, and anemia. Blood thinners can also interact with other medications and supplements, leading to excessive bleeding. It is important to consult a doctor or healthcare provider before taking any other substances while on blood thinners.
Yes, it is important to take precautions to avoid injuries that could lead to excessive bleeding. This includes using caution with sharp objects, wearing protective gear during activities, and consulting a doctor if any unusual bleeding occurs. Additionally, certain exercises are generally safe for people taking blood thinners, such as swimming, walking, and jogging.




































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