
Birth control pills, also known as oral contraceptives, are a popular form of hormonal birth control used by women worldwide. While they are primarily used for pregnancy prevention, their impact on other aspects of women's health, such as muscle gain and loss, has been a subject of interest and ongoing research. Studies have suggested that oral contraceptives may impair muscle gains in young women, potentially due to their influence on hormone levels. However, there are conflicting findings, and more research is needed to fully understand the relationship between birth control and muscle loss.
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What You'll Learn

Oral contraceptives may prevent muscle injuries
The musculoskeletal system is one of the extragonadal target tissues of sex hormones. Estrogen and progesterone receptors can be detected in the myocytes of the vastus lateralis muscle. Hormonal contraceptives can affect the musculoskeletal system, but there is a lack of high-quality studies, and no evidence-based recommendations exist regarding contraceptive methods for young female athletes.
The UT Southwestern Medical Center study found that women who take oral contraceptives are significantly less likely to experience certain musculoskeletal injuries than women who do not take the drugs or men. The findings increase our understanding of the potential protective benefits of stable hormone levels and possible concerns about hormone imbalances and musculoskeletal health.
Muscle and tendon injuries in female athletes may occur more frequently during certain phases of the menstrual cycle when estrogen levels are high and progesterone levels are low. Estrogen, found in birth control pills, can help improve muscle mass and strength while increasing the collagen content of connective tissues. Birth control pills with a mix of estrogen and progestin might help by preventing estrogen levels from spiking too high, lowering the risk of injuries.
However, it is important to note that oral contraceptives may also cause hormonal side effects, such as mood changes, depression, mental changes, and headaches. They can also interact with certain medications, potentially reducing their effectiveness or causing adverse effects.
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Birth control pills can cause hormonal side effects
Research has found that oral contraceptives can impair muscle gains in young women, with non-oral contraceptive users gaining more than 60% greater muscle mass than those taking oral contraceptives. This was observed in the context of resistance exercise training, where there were significant differences in lean mass gains between the two groups. However, it is important to note that other muscle responses, such as strength gains and arm/leg circumferences, were similar between oral contraceptive users and non-users.
Additionally, some studies suggest that birth control pills might help prevent muscle and tendon injuries due to their effects on estrogen and progesterone levels. Estrogen is necessary for maintaining reproductive and sexual health, and birth control pills can help improve muscle mass and strength while increasing the collagen content of connective tissues. However, too much estrogen can make tendons and ligaments less stiff, increasing the chance of injury.
While birth control pills can cause hormonal side effects, the impact on muscle mass and strength is still not fully understood. More research is needed to explain the differences observed in muscle gains between oral contraceptive users and non-users. Furthermore, the studies on the influence of oral contraceptives on adaptation to strength training have produced conflicting results, with some finding no effect on muscle strength and hypertrophy.
It is worth noting that the impact of birth control pills on muscle mass and strength may vary depending on individual factors such as age, BMI, and geographic location. Additionally, modern birth control pills contain lower hormone levels than those used in previous decades, and most studies oppose the theory that hormonal birth control causes significant weight gain. Any weight gain that occurs is typically due to temporary water retention rather than actual fat gain.
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Oral contraceptives may impair muscle gains
Oral contraceptives are known to affect the musculoskeletal system, and there is some evidence that they may impair muscle gains in young women. A study conducted by Chang-Woock Lee and Steven E. Riechman of Texas A&M University and Mark A. Newman of the University of Pittsburgh found significant differences in lean mass gains between women who used oral contraceptives and those who did not. The women who did not take birth control pills had 60% greater muscle mass gains than those who did. Another study by Riechman and Lee also found that oral contraceptive use impaired muscle gains in young women.
However, it is important to note that the research on this topic is limited and conflicting. Some studies have found no difference in muscle strength and hypertrophy between women who used oral contraceptives and those who did not. Additionally, modern birth control pills contain lower hormone levels than in the past, and most studies oppose the theory that hormonal birth control causes weight gain. Any weight gain that may occur is typically due to temporary water retention and is not actual fat gain.
Furthermore, oral contraceptives may have benefits in preventing certain muscle and tendon injuries. A study published in Medicine & Science in Sports & Exercise found that female participants using birth control pills were 85% less likely than male participants to experience muscle sprains or tendon strains. The researchers suggested that birth control pills might help prevent these types of injuries by regulating hormone levels, specifically estrogen and progesterone.
Overall, while there is some evidence that oral contraceptives may impair muscle gains in young women, more research is needed to fully understand the effects of oral contraceptives on muscle mass and strength. The existing research suggests that the impact of oral contraceptives on muscle gains may be complex and influenced by various factors. As such, it is important for individuals to consult with healthcare professionals to understand the potential risks and benefits of oral contraceptive use in the context of their specific circumstances.
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Birth control may increase the risk of blood clots
While birth control may offer protection against muscle and tendon injuries, it is associated with an increased risk of blood clots. This risk is especially pronounced in obese women who use oral contraceptives containing estrogen and progestin, who face a 24-fold increase in the risk of venous thromboembolism (VTE) compared to non-obese women not using these drugs.
The risk of blood clots is influenced by the type and amount of hormones in the birth control method. Estrogen has been linked to an increased risk of blood clots as it increases the levels of clotting factors in the body. The modern birth control pill contains lower doses of estrogen, with the highest dose prescribed being around 35 micrograms, compared to 50 micrograms in the 1970s and 1980s. However, even with these lower doses, the risk of blood clots remains. The risk is also affected by the type of progestin in the birth control. Pills that contain the progestin levonorgestrel tend to have a lower risk of VTE compared to pills with other types of progestins such as desogestrel, gestodene, drospirenone, or cyproterone acetate.
The contraceptive patch, vaginal ring, and combined hormonal pill are all associated with an increased risk of blood clots due to their estrogen and progestin content. The risk of blood clots with the patch may be higher than with the pill or ring, but more research is needed to confirm this. The progestin-only pill, injection, and implant are not associated with an increased risk of blood clots.
While blood clots are rare, even among birth control users, they can cause serious health problems. Blood clots can develop in the legs, lungs, or brain, with clots in these areas being particularly dangerous. A clot in the vessels moving blood from the legs is known as deep vein thrombosis (DVT), and it can break off and travel to the lungs, causing a pulmonary embolism (PE). PE can be deadly as it stops blood from getting to the lungs.
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Oral contraceptives can affect the musculoskeletal system
The musculoskeletal system is one of the extragonadal target tissues of sex hormones. Osteoblasts and osteocytes express estrogen receptors, while estrogen and progesterone receptors can be detected in the fibroblasts of the anterior cruciate ligament (ACL) and myocytes of the vastus lateralis muscle (MVL). The binding of sex hormones to these extragonadal receptors causes the musculoskeletal system to respond with structural adaptation.
Oral hormonal contraceptives can affect the musculoskeletal system. However, there is a lack of high-quality studies on this topic, and no evidence-based recommendations exist regarding contraceptive methods for young female athletes. Comparative studies have been conducted to investigate the effects of oral contraceptives on muscle strength and soft tissue changes and regeneration, which are important predictors for a higher risk of injury.
Some studies suggest that oral contraceptives may impair muscle gains in young women, particularly in the context of resistance exercise training. For example, a study by Riechman and Lee found significant differences in lean mass gains between groups of women who did and did not use oral contraceptives, with the non-OC group gaining 60% more muscle mass. Similarly, a study by Nolan et al. found that oral contraceptive use negatively impacted skeletal muscle hypertrophy, power, and strength adaptations to resistance exercise training.
On the other hand, some research indicates that oral contraceptives may reduce the risk of certain muscle and tendon injuries. A study by Rodriguez found that female participants using oral contraceptives had fewer muscle and tendon injuries compared to those who did not, and compared to male participants. This may be due to the impact of oral contraceptives on estrogen levels, as estrogen is necessary for maintaining reproductive and sexual health. High estrogen levels during certain phases of the menstrual cycle have been associated with an increased risk of muscle and tendon injuries in female athletes. By regulating estrogen levels, oral contraceptives may help lower the risk of these types of injuries.
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Frequently asked questions
There is some evidence that oral contraceptives can impair muscle gains in young women, particularly in the context of resistance training. However, other studies have found that oral contraceptives may reduce the risk of muscle and tendon injuries. More research is needed to fully understand the effects of birth control on muscle loss or gain.
Oral contraceptives can affect the musculoskeletal system by altering hormone levels. For example, birth control pills that contain estrogen can improve muscle mass and strength. However, too much estrogen can also increase the risk of injury by making tendons and ligaments less stiff.
Yes, in addition to potential muscle loss or gain, oral contraceptives can cause hormonal side effects such as mood changes, depression, mental changes, and headaches. They can also interact with certain medications and may increase the risk of blood clots in obese individuals.
If you are concerned about muscle loss or any other side effects of birth control, you should consult your doctor or healthcare provider. They can help you weigh the benefits and risks of different contraceptive methods and make a decision that is right for you.



















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