
Humira (adalimumab) is a prescription medicine used to treat several inflammatory conditions, including Crohn's disease, rheumatoid arthritis, and plaque psoriasis. It is also used to reduce the signs and symptoms of ankylosing spondylitis in adults. While Humira can be an effective treatment for these conditions, it is important to be aware of its potential side effects, which may include muscle spasms, cramps, aches, and weakness. These muscle-related symptoms are rare but can occur due to the disruption of cytokine balance or the triggering of antinuclear antibodies (ANA), which can lead to drug-induced lupus. Other side effects of Humira include allergic reactions, serious infections, increased risk of certain cancers, and nervous system problems. It is always important to consult a healthcare provider before starting or stopping any medication, including Humira, to ensure a thorough understanding of its potential benefits and risks.
| Characteristics | Values |
|---|---|
| Muscle spasms | Rare side effect |
| Muscle cramps | Reported in less than 5% of patients |
| Muscle aches | Rare side effect |
| Muscle pain | Rare side effect |
| Muscle weakness | Rare side effect |
| Muscle-related symptoms | Caused by disruption of cytokine balance |
| Drug-induced lupus | Caused by triggering antinuclear antibodies (ANA) |
| Weight gain | Observed in clinical studies |
| Allergic reactions | Mild or severe |
| Serious infections | Tuberculosis (TB), viruses, fungi, bacteria |
| Cancer | Increased chance of lymphoma or other cancers |
| Growth of new cancers | Observed in some cases |
| Existing tumor growth | Observed in some cases |
| Nervous system problems | Numbness, tingling, vision problems, weakness in arms or legs, dizziness |
| Blood problems | Decreased blood cells, fever, bruising, bleeding, paleness |
| Serious skin reactions | Blistering, peeling, skin lesions, severe acne, skin rash, sores or ulcers on the skin |
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What You'll Learn
- Humira can cause muscle spasms and cramps in less than 5% of patients
- It can also cause back pain, reported in 6% of patients
- Humira can cause serious allergic reactions, including swelling and trouble breathing
- It can also cause serious infections, including TB, which can be fatal
- Humira may increase the risk of lymphoma and other cancers in children and adults

Humira can cause muscle spasms and cramps in less than 5% of patients
Humira (adalimumab) is a prescription medicine used to treat several inflammatory conditions, including Crohn's disease, rheumatoid arthritis, and plaque psoriasis. It is also used to treat ankylosing spondylitis in adults. While Humira can be an effective treatment for many people, it is important to be aware of its potential side effects.
One rare side effect of Humira is muscle spasms and cramps. In clinical trials, muscle cramps were reported in less than 5% of patients taking Humira. Muscle aches and weakness have also been reported as rare side effects. In rare cases, Humira can disrupt cytokine balance, leading to muscle-related symptoms. Additionally, it can trigger antinuclear antibodies (ANA), which may cause drug-induced lupus, a condition that can include muscle pain.
It is important to note that side effects of Humira may vary from person to person. While muscle spasms and cramps are rare, they can be a cause for concern if they occur. If you experience persistent muscle pain, weakness, or cramps while taking Humira, it is important to consult your healthcare provider. They can help determine if the symptoms are related to Humira or if there is an underlying condition that needs to be addressed.
In addition to muscle-related side effects, Humira may also cause other mild to serious side effects. These can include injection site reactions, headaches, skin rashes, and allergic reactions. In some cases, Humira has been associated with serious infections, including tuberculosis (TB) and infections caused by viruses, fungi, or bacteria. It is crucial for patients to be tested for TB before starting treatment with Humira and to be monitored closely during treatment.
Furthermore, Humira has been linked to an increased risk of certain cancers, particularly in children, teenagers, and young adults. Some individuals have developed a rare type of cancer called hepatosplenic T-cell lymphoma, which often has severe consequences. Therefore, it is imperative to carefully consider the risks and benefits of Humira therapy and to consult a healthcare professional before starting or discontinuing treatment.
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It can also cause back pain, reported in 6% of patients
Humira (adalimumab) is a prescription medicine used to reduce the signs and symptoms of ankylosing spondylitis in adults. It is also approved by the Food and Drug Administration (FDA) to treat several different inflammatory conditions, including Crohn's disease, rheumatoid arthritis, and plaque psoriasis. Humira works by blocking tumor necrosis factor-alpha (TNF-α), a protein involved in inflammation.
While Humira can be an effective treatment for these conditions, it is important to be aware of its potential side effects. One of the possible side effects of Humira is back pain, which has been reported in 6% of patients taking the medication. This is a relatively low percentage compared to other side effects, but it is still a possibility that patients should be aware of.
Back pain can be a bothersome and debilitating symptom, impacting a person's mobility, comfort, and overall quality of life. It can interfere with daily activities, such as sitting, standing, walking, or sleeping. The intensity of back pain can vary, ranging from mild discomfort to severe pain. It can be acute, lasting for a short period, or become a chronic condition, persisting for weeks, months, or even years.
If you are experiencing back pain while taking Humira, it is important to consult your healthcare provider. They can evaluate your symptoms, determine the underlying cause, and provide appropriate treatment or management options. Depending on the severity and impact on your life, your healthcare provider may suggest over-the-counter pain relievers, recommend lifestyle changes or physical therapy, or refer you to a specialist for further evaluation and treatment.
It is important to remember that side effects of medications like Humira can vary from person to person, and not everyone will experience the same symptoms. Some people may experience mild side effects, while others may have more severe reactions. It is always advisable to discuss any concerns or questions about side effects with your doctor or pharmacist, as they can provide personalized advice and guidance.
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Humira can cause serious allergic reactions, including swelling and trouble breathing
While Humira (adalimumab) is used to treat several inflammatory conditions, it can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days or weeks. However, if the side effects bother you or become severe, it is important to consult your doctor or pharmacist.
One of the serious side effects that can occur with Humira use is an allergic reaction. Allergic reactions to Humira can range from mild to severe. Mild allergic reactions may manifest as a mild skin rash, whereas severe allergic reactions can include swelling of the face, eyes, lips, or mouth, as well as trouble breathing.
If you experience any symptoms of an allergic reaction, it is important to call your doctor right away. They may recommend treatments or alternative medications to manage your symptoms. If the symptoms are severe, such as swelling or trouble breathing, it is crucial to call 911 or your local emergency number immediately, as these symptoms can become life-threatening and require urgent medical attention.
It is important to note that Humira may also cause other serious side effects, such as nervous system problems, blood disorders, and an increased risk of infections, including tuberculosis (TB) and infections caused by viruses, fungi, or bacteria. Some people have died from these infections, hence the importance of consulting your doctor before starting Humira and being closely monitored during treatment.
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It can also cause serious infections, including TB, which can be fatal
Humira (adalimumab) is a medication used to treat autoimmune issues. It works by blocking a protein called tumour necrosis factor-alpha (TNF-α), which is involved in inflammation. While Humira can be effective for managing autoimmune conditions, it also carries a risk of serious side effects, including an increased susceptibility to infections.
Due to the way Humira affects the immune system, patients taking this medication may become more susceptible to infections, which in some cases can be life-threatening. These infections may be bacterial, viral, or fungal, and they can include tuberculosis (TB), hepatitis B, Legionella, and Listeria. Patients taking Humira are advised to be vigilant about monitoring and treating even minor infections, such as a cold or graze, to prevent them from progressing into more serious infections. It is crucial for patients to inform their doctors if they experience any symptoms indicative of an infection, such as fever, fatigue, persistent cough, wounds, skin sores, dental problems, or burning during urination.
The risk of developing infections while on Humira treatment is particularly elevated for patients with a history of chronic or recurrent infections. It is recommended that patients be evaluated for latent TB and treated if necessary before initiating Humira therapy. Additionally, patients should be closely monitored for signs and symptoms of infection during and after treatment, as the development of TB has been observed even in patients who tested negative for it prior to treatment.
It is important to note that Humira may also cause other serious side effects, such as nerve damage, liver problems, and increased risk of cancer. Patients taking Humira should be aware of these potential risks and remain in close communication with their healthcare providers to ensure their safety.
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Humira may increase the risk of lymphoma and other cancers in children and adults
Muscle spasms, cramps, aches, and weakness are rare side effects of Humira. Back pain was reported in 6% of patients taking Humira, while muscle cramps were reported in less than 5% of patients. In rare cases, Humira can disrupt cytokine balance, leading to muscle-related symptoms, or trigger antinuclear antibodies (ANA), which may cause drug-induced lupus—a condition that can include muscle pain.
Humira (adalimumab) is a prescription medicine used to reduce the signs and symptoms of ankylosing spondylitis in adults. It is also approved by the Food and Drug Administration (FDA) to treat several different inflammatory conditions, including Crohn's disease, rheumatoid arthritis, and plaque psoriasis.
Serious infections have also occurred in people taking Humira, including tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting Humira and monitor you closely during treatment.
Other serious side effects of Humira include nervous system problems, allergic reactions, and blood problems. Symptoms of a serious allergic reaction include hives, trouble breathing, and swelling of the face, eyes, lips, or mouth. Nervous system problems can include numbness or tingling, vision problems, weakness in the arms or legs, and dizziness. Symptoms of blood problems include a persistent fever, easy bruising or bleeding, and extreme pallor.
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Frequently asked questions
Muscle spasms, cramps, aches, and weakness are rare side effects of Humira. Back pain was reported in 6% of patients taking Humira, while muscle cramps were reported in less than 5% of patients.
Humira can cause allergic reactions, with symptoms ranging from mild rashes to severe reactions such as swelling or trouble breathing. Other side effects include nervous system problems, serious infections such as tuberculosis, and increased risk of certain cancers.
If you experience any side effects from Humira, it is important to consult your doctor or pharmacist. They can help manage your symptoms or discuss alternative treatment options. Do not stop taking Humira without first consulting your doctor.




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