
Phencyclidine, commonly known as PCP, is a dissociative general anesthetic that was first discovered in 1926 and introduced for medical use in the 1950s. Due to its severe adverse effects, including psychosis and dysphoria, its clinical use was discontinued in 1965. Despite this, PCP remains a commonly abused substance, with millions of people having tried it. The drug has various street names, including angel dust and rocket fuel, and can be ingested orally, injected intravenously, inhaled, or smoked. PCP use can lead to a range of adverse outcomes, including hallucinations, paranoia, delusions, aggression, physical injuries, and mental distress. In addition to these immediate effects, PCP abuse can result in withdrawal symptoms such as anxiety, agitation, and impaired reflexes when drug use is stopped. Of particular interest, PCP overdose can cause muscle rigidity, among other serious symptoms such as coma, convulsions, high blood pressure, and seizures.
| Characteristics | Values |
|---|---|
| PCP common names | Rocket fuel, angel dust, peace pill, crystal joints, zoom, the sheets, elephant tranquilizer |
| PCP form | Powder, crystal, liquid, tablet |
| PCP overdose effects | Coma, Convulsions, elevated blood pressure, high pain tolerance, loss of muscle control, muscle rigidity, seizures, death |
| PCP withdrawal symptoms | Agitation, anxiety, confusion, depression, diminished speech, impaired reflexes, memory problems, muscle twitches, seizures |
| PCP short-term effects | Nausea, vomiting, severe anxiety, paranoia, flashbacks, violent behaviour |
| PCP long-term effects | Memory loss, depression, weight loss, trouble with speaking or thinking, suicidal thoughts, social withdrawal |
| PCP effects | Nystagmus, horizontal, vertical, rotary, hypertension, tachycardia, numbness, diminished responsiveness to pain, ataxia, dysarthria, muscle rigidity, seizures, coma, lethargy, sedation, psychosis, hallucinations, delusions, violent behaviour, agitation, hyperthermia, hypoxia, respiratory problems, cardiovascular problems, neurological toxicity, dystonia, dyskinesias, catalepsy, hypothermia |
| PCP use in 2023 | 24,000 individuals aged 12 and older |
| PCP use in 2011 | 75,538 emergency department visits |
What You'll Learn

PCP overdose can cause muscle rigidity
PCP, or phencyclidine, is a dangerous and life-threatening substance that can cause a range of adverse outcomes. It is a dissociative general anesthetic that was first introduced in the 1950s but was discontinued in 1965 due to its severe adverse effects. Despite this, PCP remains a commonly used recreational drug, with millions of people having tried it.
PCP abuse can lead to physical injuries, mental distress, and a powerful urge to use the drug again. It can cause hallucinations, paranoia, delusions, and aggressive behaviour. The drug also has a range of physiological effects, including high blood pressure, elevated heart rate, profuse sweating, flushed skin, numbness in the extremities, inability to feel pain, blurred vision, difficulty speaking, uncontrolled eye movement, lack of body control, and rigid muscles.
PCP overdose is a serious concern, and it is important to seek emergency medical care if overdose effects become apparent. PCP overdose can cause muscle rigidity, along with other symptoms such as coma, convulsions, elevated blood pressure, high pain tolerance, and loss of muscle control. The Drug Abuse Warning Network reported that there were 75,538 emergency department visits related to PCP in 2011, a 400% increase from 2005.
The effects of PCP can vary depending on the dose, route of administration, and co-ingested substances. It can be ingested orally, injected intravenously, inhaled, or smoked. PCP interacts with other drugs, and its effects can be enhanced or altered when mixed with certain substances. For example, mixing PCP with chlorpromazine can result in severely low blood pressure. PCP use can also lead to withdrawal symptoms, including anxiety, agitation, confusion, depression, impaired reflexes, memory problems, muscle twitches, and seizures.
Overall, PCP overdose can cause muscle rigidity, and it is a serious medical condition that requires immediate attention. The abuse of PCP carries significant risks and can lead to various adverse physical and mental effects.
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PCP withdrawal symptoms include muscle twitches
PCP, or phencyclidine, is a dangerous and life-threatening substance of abuse that can cause a range of adverse outcomes. It was originally introduced as a dissociative general anesthetic in the 1950s but was discontinued in 1965 due to its severe adverse effects. PCP abuse has led to a large number of emergency room visits, with nearly 80,000 people requiring immediate medical treatment.
PCP withdrawal symptoms can emerge if the use of this drug suddenly stops, indicating that the body has become accustomed to the drug. These withdrawal symptoms include agitation, anxiety, confusion, depression, diminished speech, impaired reflexes, memory problems, and muscle twitches. More severe reactions, such as seizures and hallucinations, may also occur.
Muscle rigidity is associated with PCP intoxication, which occurs when there is a clinically significant problematic physiological, behavioural, or psychological change. Intoxication with PCP can result in disorganized thought processes, including delirium, amnesia, paranoia, and dysphoria. It can also cause motor disturbances and loss of muscular coordination, leading to a lack of body control.
The effects of PCP can be rapid, taking hold within 1 to 5 minutes when smoked or injected, and up to 30 minutes if taken orally or snorted. The major effects can last for 4 to 6 hours, and it may take 24 hours for a person to fully return to their normal state. PCP is a potent and addictive drug, and withdrawal symptoms can be challenging to manage without professional treatment.
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PCP intoxication causes disorganized thought processes
PCP, or phencyclidine, is a dissociative general anesthetic that was first discovered in 1926. It was introduced for clinical use in the 1950s but was discontinued in 1965 due to severe adverse effects. PCP is a dangerous and illegal substance of abuse that can cause a range of adverse outcomes, including physical injuries, mental distress, and addiction. PCP abuse has led to a significant number of emergency room visits, with almost 80,000 people requiring immediate medical treatment.
The psychobehavioral features of PCP intoxication often mimic symptoms of schizophrenia, with users experiencing anxiety, paranoia, disorganized thinking, and a sensation of distance from their environment. PCP intoxication can also cause violent behavior, with users acting in an unpredictable and aggressive manner, driven by their delusions or hallucinations. However, it is important to note that media reports of PCP-induced violence may be exaggerated, and incidents of violence are typically limited to individuals with pre-existing aggressive tendencies.
PCP abuse can lead to both short-term and long-term effects on the body and mind. In the short term, PCP intoxication can cause nystagmus, motor disturbances, autonomic stimulation, and fluctuating behavior. The mental status of PCP-intoxicated individuals can vary, ranging from stimulation and euphoria to depression and coma, depending on the dose. At high doses, PCP can cause seizures, coma, hyperthermia, and death, often related to unintentional injury or suicide while intoxicated.
Long-term abuse of PCP can produce memory loss, speech difficulties, depression, and weight loss. Addiction and withdrawal from PCP can occur with chronic use, leading to cravings and compulsive PCP-seeking behavior. Treatment for PCP intoxication primarily consists of supportive care, controlling breathing, circulation, and body temperature, and managing psychiatric symptoms with medications such as benzodiazepines and antipsychotics.
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PCP abuse can lead to violent behaviour
PCP, or phencyclidine, is a dissociative drug that was originally developed as an anesthetic. Its use was discontinued in 1965 due to its severe adverse effects, but it has since become a substance of abuse. PCP abuse can lead to violent behaviour through several mechanisms:
Firstly, PCP causes disorganized thought processes, including paranoia, delusions, and hallucinations. These effects can lead to feelings of aggression and a loss of impulse control, resulting in violent outbursts. PCP users have reported feeling stronger than they are and engaging in violent behaviour, which can cause harm to themselves or others. The drug's effects can be felt within 2-5 minutes of consumption and can last for up to 24 hours, increasing the risk of violent incidents during this period.
Secondly, PCP intoxication can result in motor disturbances and loss of muscular coordination, as well as a high pain tolerance. This combination of effects can lead to unintentional injuries and violent behaviour. In some cases, PCP users have walked into traffic or jumped from buildings, endangering themselves and others.
Thirdly, PCP abuse can cause agitation, anxiety, and confusion, which can contribute to violent behaviour. The drug's stimulant effects can heighten arousal and increase the likelihood of aggressive responses, particularly in individuals with pre-existing mental health issues or a history of violence.
Finally, PCP is often abused in combination with other substances, such as alcohol or other sedatives. This can enhance the drug's sedative effects, leading to coma and respiratory depression. Additionally, the combination of PCP with stimulants can increase the risk of violent behaviour by exacerbating the stimulant effects of PCP.
In conclusion, PCP abuse can lead to violent behaviour through a range of physiological and psychological effects. The drug's impact on thought processes, motor control, pain perception, and arousal levels increases the risk of aggression and unintentional injuries. The severity and duration of PCP's effects further contribute to the potential for violent incidents. Therefore, it is crucial to seek professional treatment for PCP abuse and to be vigilant in recognizing the signs of intoxication to prevent harmful consequences.
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PCP toxicity can result in neurological issues
PCP, or phenylcyclohexyl piperidine, is a dissociative drug that was introduced as a general anesthetic in the 1950s. Due to its severe adverse effects, including postoperative psychoses and dysphoria, its clinical use was discontinued in 1965. Despite this, PCP continues to be abused, with millions of people having tried it, according to the National Survey on Drug Use and Health.
- Nystagmus, or uncontrolled eye movement
- Intracranial hemorrhage
- Rhabdomyolysis
- Respiratory problems
- Cardiovascular problems, such as cardiac arrest
- Dystonia
- Dyskinesias
- Catalepsy
- Hypothermia or hyperthermia
- Seizures
- Coma
In addition to these neurological issues, PCP toxicity can also cause a range of other physiological and psychological effects, including high blood pressure, elevated heart rate, profuse sweating, flushed skin, numbness in the extremities, inability to feel pain, blurred vision, difficulty speaking, lack of body control, rigid muscles, a staring gaze, and unconsciousness. PCP use can also lead to violent or aggressive behavior, with users reporting feelings of strength and invulnerability that can result in unintentional harm to themselves or others.
The dangers of PCP abuse are well-documented, with PCP accounting for a large number of emergency room visits in the last decade. It is important for individuals to be aware of the risks associated with PCP use and to seek professional treatment if needed.
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Frequently asked questions
Phenylcyclohexyl piperidine (PCP), also known as phencyclidine, is a dissociative general anesthetic that was introduced in the 1950s. It is also a commonly used recreational drug.
PCP causes a range of physiological and psychological effects, including hallucinations, paranoia, delusions, disorganized thought processes, high blood pressure, elevated heart rate, profuse sweating, blurred vision, lack of body control, rigid muscles, and unconsciousness. PCP is highly addictive and can cause withdrawal symptoms such as anxiety, agitation, and seizures.
PCP is a dangerous and life-threatening substance that can lead to unintentional harm and violence, as well as mental distress. PCP abuse has resulted in a large number of emergency room visits, with some cases leading to coma, seizures, hyperthermia, and death.

