
Psoriatic arthritis (PsA) is a musculoskeletal disease that can cause muscle pain. It is an inflammatory condition that affects joints, including the fingers, toes, hips, knees, and spine. PsA causes joint pain, stiffness, and swelling, which can lead to inactivity and muscle wasting. While muscle pain is not a typical symptom of PsA, some people with the disease also develop fibromyalgia, which is characterised by muscle pain, joint stiffness, and fatigue. Treatment for PsA aims to manage symptoms and prevent joint damage, as there is currently no cure.
Does psoriatic arthritis cause muscle pain?
| Characteristics | Values |
|---|---|
| Inflammation | Psoriatic arthritis is a form of joint inflammation that causes swelling in the joints. |
| Muscle wasting | Psoriatic arthritis can cause muscle wasting and decreased skeletal muscle mass and strength. |
| Nutritional deficiencies | Nutritional deficiencies can cause muscle wasting in people with psoriatic arthritis. |
| Chronic inflammation | Chronic inflammation can cause muscle wasting in people with psoriatic arthritis. |
| Reduced physical activity | Reduced physical activity can cause muscle wasting in people with psoriatic arthritis. |
| Inactivity | Inactivity and bed rest can cause muscles to reduce and become weak in people with psoriatic arthritis. |
| Obesity | Obesity can worsen psoriatic arthritis symptoms and increase musculoskeletal pain. |
| Fibromyalgia | Some people with psoriatic arthritis also have fibromyalgia, which causes muscle pain, joint stiffness, and fatigue. |
| Treatment | Early treatment with medication can help manage inflammation and reduce muscle pain, stiffness, and pain. |
| Exercise | Physical activity can improve muscle strength and reduce pain. |
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What You'll Learn
- Psoriatic arthritis (PsA) is a musculoskeletal disease that can cause muscle wasting and decreased skeletal muscle mass
- PsA can cause inflammatory back pain, which is worse with inactivity and in the morning
- PsA can lead to inactivity and bed rest, which can cause muscles to reduce and become weak
- Obesity can contribute to inflammation and worsen PsA symptoms, including muscle pain
- Fibromyalgia, which causes muscle pain, is often present in people with PsA

Psoriatic arthritis (PsA) is a musculoskeletal disease that can cause muscle wasting and decreased skeletal muscle mass
PsA can cause muscle pain and stiffness, leading to a reduction in physical activity and potentially resulting in muscle wasting and loss of lean muscle mass. This loss of muscle mass can lead to weakness and disability. Inactivity and bed rest have been linked to a decrease in muscle strength and atrophy. Additionally, inflammatory proteins in the blood can stimulate protein breakdown and reduce protein production in the muscles, contributing to muscle wasting.
The pain associated with PsA can be managed through early treatment with medication and physical activity. Nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs) are commonly used to reduce pain and inflammation. Doctors may also prescribe targeted synthetic DMARDs or biologics that target specific inflammatory proteins. Physical activity, including low-impact exercises such as swimming, walking, and yoga, can help improve muscle strength, reduce pain, and prevent stiffness.
It is important to note that PsA can resemble other types of arthritis, such as rheumatoid arthritis, and a correct diagnosis is crucial for appropriate treatment. Additionally, obesity can contribute to inflammation and worsen PsA symptoms, making some medications less effective. Seeking treatment for PsA is essential to manage symptoms and reduce the risk of complications.
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PsA can cause inflammatory back pain, which is worse with inactivity and in the morning
Psoriatic arthritis (PsA) is an inflammatory condition that causes swelling in the joints and can result in muscle pain. It affects the joints, spine, or ligaments/tendons. It can cause inflammatory back pain, which is worse during periods of inactivity and in the morning.
PsA can cause back pain, which is a symptom that may develop alongside the more commonly known symptoms of skin problems and joint pain. When the spine is affected, it is known as axial arthritis or spondylitis. Spondylitis affects the spine and sacroiliac joints, located at the bottom of the back. Many people with PsA have axial arthritis, and most of them will have a mix of peripheral and axial arthritis. However, a smaller number of people with PsA can have inflammation primarily in the axial area without peripheral symptoms.
The back pain associated with PsA is worse with inactivity and in the morning. It improves with activity and is worse with rest. It occurs gradually and is chronic, lasting more than three months. Once the inflammation is managed, exercise can be introduced to improve muscle strength and reduce pain. Low-impact exercises such as swimming, walking, tai chi, yoga, and Pilates can help stretch the muscles and prevent stiffness. It is recommended to consult a doctor before trying high-impact exercises.
Inactivity and bed rest can cause muscles to reduce and become weak, leading to muscle wasting and decreased skeletal muscle mass and strength. This can result in a loss of muscle mass in people with PsA. People with PsA who experience chronic pain are more likely to be sedentary, which can further contribute to muscle wasting. Obesity can also increase musculoskeletal pain and make PsA medications less effective.
Treatment for PsA aims to manage symptoms and prevent joint damage. Early treatment with medication can help manage inflammation and reduce pain and stiffness. Nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic drugs (DMARDs), biologics, and targeted synthetic DMARDs are some of the medications used to treat PsA.
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PsA can lead to inactivity and bed rest, which can cause muscles to reduce and become weak
Psoriatic arthritis (PsA) is an inflammatory condition that causes swelling in the joints and other symptoms. It is a form of arthritis that affects some people with psoriasis, a skin condition causing flare-ups of red, scaly rashes and thickened, pitted nails. PsA resembles rheumatoid arthritis but does not produce the same antibodies. It can cause muscle pain, joint stiffness, and fatigue, with the most severe form being arthritis mutilans, which causes inflammation that damages the small bones in the hands and feet.
PsA can cause pain and stiffness, which may result in reduced physical activity and bed rest. Inactivity and bed rest can lead to muscle wasting and a decrease in skeletal muscle mass and strength. This loss of lean muscle mass can cause weakness and disability. A 2017 study found that PsA may cause the loss of muscle mass, particularly in postmenopausal people with PsA. However, the researchers noted limited research on muscle mass and arthritis, with most studies focusing on rheumatoid arthritis.
People with PsA who experience chronic pain may be less likely to engage in weight-bearing exercises and more likely to be sedentary, contributing to muscle wasting. Nutritional deficiencies, chronic inflammation, and reduced physical activity can also cause muscle wasting. A 2020 study using MRI scans found that people with PsA experienced a significant decrease in hand muscle volume with age, with the decrease being twice as significant in men compared to women.
It is important for individuals with PsA to discuss their symptoms with a doctor, who may refer them to a dermatologist or rheumatologist for further evaluation. Doctors may recommend early treatment with medication to manage inflammation and reduce pain, muscle pain, and stiffness. Physical activity has been shown to improve muscle strength and reduce pain. Low-impact exercises such as swimming, walking, tai chi, yoga, and Pilates can help stretch muscles and prevent stiffness.
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Obesity can contribute to inflammation and worsen PsA symptoms, including muscle pain
Psoriatic arthritis (PsA) is an inflammatory condition that causes swelling in the joints and other symptoms. It is a musculoskeletal disease that can involve the joints, spine, or ligaments/tendons. The musculoskeletal pain can present in four ways: axial arthritis (arthritis of the spine), peripheral arthritis (arthritis of the joints of the arms and legs), dactylitis (swollen fingers or toes), and enthesitis (inflammation of the site where a ligament or tendon inserts into a bone).
Obesity is more common in people with PsA than in those without it. Research shows that those with both conditions are more likely to develop other related diseases, such as high blood pressure, diabetes, and high cholesterol. Obesity can contribute to inflammation, which can worsen PsA symptoms, including muscle pain. This is because fat tissue produces proteins, such as cytokines, chemokines, and adipokines, which promote inflammation. Obesity is considered by scientists to be an ongoing state of low-grade inflammation that contributes to several diseases, including PsA.
In addition, obesity can put more pressure on the joints, ligaments, and tendons, leading to increased pain and further reducing physical activity levels. This can create a cycle where reduced activity and bed rest cause muscles to reduce and become weak, leading to further weight gain and increased pressure on the joints. Obesity can also make PsA medications, such as TNF blockers and DMARDs, less effective.
However, it is important to note that the relationship between PsA and obesity is complex, and it is not clear whether obesity results from or contributes to PsA. Managing weight can help improve PsA symptoms and overall health. For example, a 2019 study found that short-term weight loss on a very low-calorie diet improved PsA symptoms. Additionally, losing weight can improve the body's response to PsA medications, as some treatments appear to work more effectively when people with obesity lose weight.
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Fibromyalgia, which causes muscle pain, is often present in people with PsA
Psoriatic arthritis (PsA) is an inflammatory condition that causes swelling in the joints and other symptoms. It is a form of joint inflammation that occurs in some people who have psoriasis of the skin or nails. PsA can cause muscle pain and stiffness, which may result in a person being unable to get enough regular physical activity, affecting their muscle strength and mass.
The two conditions share many common characteristics and can exist alone or together. They both cause whole-body symptoms, including pain, chronic fatigue, and brain fog. However, they also have unique features. Unlike PsA, fibromyalgia is not an autoimmune or inflammatory disease, and there is no evidence that it causes inflammation. Instead, research suggests that the nervous system is involved, with increased levels of certain pain-signaling chemicals in the brain.
Diagnosing fibromyalgia can be challenging, as there is no specific test for it. It tends to be a diagnosis of exclusion, where other conditions with similar symptoms are ruled out first. Doctors may use measures such as the widespread pain index score and the presence of "fibro fog," or cognitive symptoms, to help diagnose fibromyalgia.
Treating both conditions simultaneously can be challenging. Medications that typically work well for people with PsA, such as NSAIDs, may not provide significant improvements for those with fibromyalgia. Therefore, it is important to consider the impact of fibromyalgia when treating people with PsA and to manage and treat both conditions effectively.
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Frequently asked questions
Psoriatic arthritis (PsA) is a form of arthritis that affects some people with psoriasis, a skin condition causing red patches of skin topped with silvery scales. It causes joint pain, stiffness, and swelling, and can affect any part of the body, including fingertips and the spine.
Psoriatic arthritis causes swollen fingers and toes, which can look like sausages. It can also cause foot pain, lower back pain, and neck pain. Some people with PsA also develop fibromyalgia, which can cause muscle pain, joint stiffness, and fatigue.
Treatment for psoriatic arthritis aims to control symptoms and prevent joint damage. Nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs) can help manage inflammation and pain. Doctors may also prescribe biologics, which are drugs made from living cells that target inflammatory proteins.
While muscle pain is not a typical symptom of PsA, some people with the disease also get fibromyalgia, which can cause muscle pain. Additionally, inactivity due to PsA pain and stiffness can lead to muscle wasting and weakness.










































