
Testosterone is a hormone that stimulates sperm production and sex drive, and helps build muscle and bone mass. Topical testosterone is a prescription drug that is applied to the skin to treat hypogonadism, a condition characterised by low testosterone levels. While testosterone therapy is typically associated with men, it has also been prescribed off-licence for women, particularly perimenopausal and menopausal women, to improve sexual function and general well-being. However, it is important to note that testosterone therapy may cause side effects in women, such as hair growth in unusual places, acne, and changes in the menstrual cycle. Therefore, it is crucial to consult a doctor before starting testosterone therapy to weigh the potential benefits against the risks.
| Characteristics | Values |
|---|---|
| Use in women | Testosterone therapy is sometimes prescribed off-license for women, especially perimenopausal and menopausal women, to improve sexual function and general well-being. |
| Side effects in women | Unwanted hair growth, acne, birth defects in pregnant people, early puberty in children, development of male characteristics, deepening of voice, genital enlargement, decrease in breast size, male-pattern hair loss, unusual menstrual cycles, fluid retention, weight gain, nausea, headaches, mood changes, jaundice, increase in cholesterol, high calcium in the blood, and harm to infants during breastfeeding. |
| Precautions | Women and children should avoid contact with unwashed or unclothed skin where testosterone gel has been applied. After applying, wash hands with soap and water, and allow the medication to dry before putting on clothing that covers the area. |
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What You'll Learn
- Testosterone creams are not licensed for use in women, only men
- Testosterone can improve sexual function and general wellbeing in menopausal women
- Testosterone creams can cause skin problems like itching and rashes
- Testosterone can cause early puberty in children and male features in females
- Testosterone can cause high calcium levels in the blood, leading to muscle weakness

Testosterone creams are not licensed for use in women, only men
Testosterone is a hormone that stimulates sperm production and sex drive and helps build muscle and bone mass. Testosterone levels typically peak in early adulthood and decrease with age. Topical testosterone is a prescription drug that is applied to the skin and is used to treat hypogonadism, a condition characterised by low testosterone levels. While testosterone creams and gels can be beneficial to those with low testosterone, they are not without their side effects. Topical testosterone can cause skin problems like itching or rashes, and in those with female anatomy, it can cause unwanted hair growth, acne, or birth defects in pregnant people. It may also cause high calcium levels in the blood, which can lead to muscle weakness, frequent urination, thirst, stomach pain, and blood in the urine.
Testosterone creams and gels are not licensed for use in women, only men. This means that while a doctor may prescribe them to women, they are doing so off-label. Women who are prescribed testosterone gels or creams are generally given a lower dose than men. This is because testosterone levels in women are normally much lower than in men. The British Menopause Society (BMS) has released guidance on testosterone prescribing, suggesting products and doses that can be used. However, there are currently no licensed preparations for women in the UK. Androfeme, a testosterone cream designed for menopausal women, is currently licensed in Australia but not in the UK.
The side effects of testosterone gels and creams in women are primarily due to the drug causing the development of male characteristics. These can include hair growth on the face, a deeper voice, and an increase in acne. In children, exposure to testosterone gels or creams can cause early symptoms of puberty. Women who are breastfeeding should also avoid using testosterone gels or creams as studies have demonstrated harmful infant effects. Additionally, women and children should avoid contact with unwashed or unclothed areas where the gel or cream has been applied to avoid accidental exposure.
While testosterone creams and gels are not licensed for use in women, they have been shown to have benefits for menopausal women. Testosterone can improve sexual function and general well-being in menopausal women, including sexual desire, pleasure, arousal, orgasm, and self-image. It has also been shown to improve urogenital, psychological, and somatic symptoms, increase bone density, and enhance cognitive performance when combined with oestrogen. However, it is important to note that testosterone therapy is not the first line of treatment for menopausal symptoms. The National Institute for Health and Care Excellence (NICE) guidelines state that testosterone supplementation can be considered for menopausal women with low sexual desire if hormone replacement therapy (HRT) alone is not effective.
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Testosterone can improve sexual function and general wellbeing in menopausal women
Testosterone is a hormone that stimulates sperm production and sex drive, and helps build muscle and bone mass. Testosterone levels typically peak in early adulthood and slowly decrease with age.
Topical testosterone is a prescription drug that is applied to the skin. It is used to treat hypogonadism, a condition characterised by low testosterone levels that can be caused by several factors. While testosterone creams can cause side effects such as skin irritation and unwanted hair growth in women, they have been found to improve sexual function in menopausal women. Recognised benefits include improved sexual desire, arousal, orgasm, and pleasure, as well as reduced concerns and distress about sex. Testosterone supplementation has also been shown to improve urogenital, psychological, and somatic symptoms, increase bone density, and enhance cognitive performance when combined with oestrogen as part of Hormone Replacement Therapy (HRT).
The National Institute for Health and Care Excellence (NICE) guidelines state that testosterone supplementation can be considered for menopausal women with low sexual desire if HRT alone is ineffective. The British Menopause Society (BMS) 2016 recommendations suggest that this indication could be extended to include menopausal women with low sexual desire and tiredness. Adequate testosterone levels are important for the maintenance of musculoskeletal health and possibly vascular and brain function. Numerous studies have demonstrated that adding testosterone to hormonal therapy can improve sexual function and general wellbeing in menopausal women.
An international task force of experts from leading medical societies convened by the International Menopause Society has developed a Global Position Statement to provide guidance on the prescribing and measurement of testosterone for female testosterone therapy. They concluded that testosterone can effectively improve sexual wellbeing in menopausal women with hypoactive sexual desire dysfunction (HSDD). It is important to note that testosterone should be used under medical supervision, and women should be adequately oestrogenised before adding testosterone to their regimen. While testosterone appears to be safe when used transdermally and in low doses, there is limited long-term safety data beyond two years of use.
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Testosterone creams can cause skin problems like itching and rashes
Testosterone creams can be used to treat low testosterone levels in men. However, it is important to note that testosterone is a typically male hormone, and its use can cause side effects in females and children. Specifically, testosterone creams can cause skin problems like itching or rashes.
Testosterone creams are prescription drugs that are applied to the skin. They are used to treat hypogonadism, a condition characterised by low testosterone levels, which can be caused by Klinefelter's syndrome, primary testicular failure, or undescended testicles, among other conditions. While testosterone creams can help increase testosterone levels, they can also lead to various side effects.
One of the most common side effects of testosterone creams is skin irritation, including itching and rashes. This can occur at the site of application, where the cream is applied to the skin. It is important to carefully follow the application instructions and to wash the hands after applying the cream to prevent accidental exposure and skin irritation.
In individuals with female anatomy, testosterone creams can cause additional skin-related side effects, such as unwanted hair growth and acne. These side effects can be particularly troublesome as they may lead to the development of male characteristics in females. It is crucial for females and children to avoid contact with the skin of individuals using testosterone creams, as transfer can result in the development of these symptoms.
To prevent skin problems and minimise the risk of side effects, it is recommended to keep the treated area covered or to wash it thoroughly before coming into contact with others. Additionally, individuals using testosterone creams should follow the instructions provided by their healthcare provider and be cautious of potential interactions or contraindications.
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Testosterone can cause early puberty in children and male features in females
Testosterone is a hormone produced by the gonads (testicles or ovaries). Testosterone levels are naturally much higher in males, and the hormone helps maintain male characteristics, including muscle strength and mass, facial and body hair, and a deep voice. Typically, testosterone levels peak in early adulthood and gradually decline with age.
In females, high testosterone levels can lead to the development of male characteristics, which are typically considered undesirable. For female infants, high testosterone can cause an enlarged clitoris, resembling a penis. It can also cause early puberty, which is defined as the onset of puberty before the age of eight or nine. In female adults, high testosterone may indicate polycystic ovary syndrome (PCOS), which affects up to 15% of females of reproductive age. Symptoms of high testosterone in females include excess body and facial hair (hirsutism), acne, irregular menstruation, balding, and a deeper voice. These symptoms can be treated with medication and lifestyle changes.
In male children, excess testosterone can also cause precocious (early) puberty. Puberty in boys typically begins between the ages of nine and fourteen, so testosterone-induced early puberty would precede this timeframe.
Testosterone topical gels are used to treat hypogonadism, a condition characterised by low testosterone levels. This condition can be caused by various factors, including Klinefelter's syndrome, primary testicular failure, or undescended testicles. However, children and women should avoid contact with the unwashed or unclothed area where the testosterone gel has been applied.
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Testosterone can cause high calcium levels in the blood, leading to muscle weakness
Testosterone creams are a prescription medication used to treat hypogonadism, a condition characterised by low testosterone levels. Typically, testosterone helps maintain male characteristics such as muscle strength and mass, facial and body hair, and a deep voice. However, the use of testosterone creams can cause side effects, particularly in women.
Women and children should avoid contact with the application site of testosterone creams on another person's body, as exposure can cause the development of male characteristics in females and early puberty in children. When applied topically, testosterone creams can cause skin problems like itching or rashes, and in women, they can also lead to unwanted hair growth, acne, or birth defects in pregnant individuals.
Testosterone creams can also cause high calcium levels in the blood, a condition known as hypercalcaemia. This can lead to several symptoms, including muscle weakness, frequent urination, increased thirst, stomach pain, and blood in the urine. Additionally, high calcium levels can be especially dangerous for individuals with cancer.
While testosterone creams can cause high calcium levels in the blood, the relationship between testosterone and calcium is complex and not fully understood. Studies have found gender differences in the renal handling of calcium, with male mice exhibiting higher urinary calcium excretion than female mice. However, the overall contribution of androgens to these differences remains uncertain.
In summary, while testosterone creams can be an effective treatment for hypogonadism in men, they can cause various side effects, especially in women. One of the potential side effects is high calcium levels in the blood, which can lead to muscle weakness and other symptoms. Therefore, it is important to carefully follow the instructions provided with the medication and consult a healthcare professional if any adverse effects occur.
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Frequently asked questions
Testosterone is a hormone that stimulates sperm production and sex drive and helps build muscle and bone mass. Testosterone cream is a prescription drug that is applied to the skin.
Testosterone cream can cause serious side effects for women, especially if used in high doses or in ways other than directed by a doctor. These side effects include hair growth in unusual places, acne, birth defects in pregnant people, deepening of the voice, genital enlargement, decrease in breast size, male-pattern hair loss, and unusual menstrual cycles.
Testosterone cream can lead to an increase in muscle mass for women. However, it is important to note that testosterone cream is not licensed for use in women and should only be used under the supervision of a doctor.
Women and children should avoid contact with the skin where testosterone cream has been applied as it can cause early puberty in children and the development of male features in women. It is important to wash hands thoroughly with soap and water after applying the cream and to ensure the area is covered with clothing.











































