
Muscle hypertrophy, or muscle building, refers to an increase in muscle mass, size and strength. It is caused by strength training, such as weight lifting, which increases the cross-sectional area of individual muscle fibres. This occurs through the synthesis and accumulation of new myofilaments, which expand the fibre volume. Muscle hypertrophy can be measured using modern imaging techniques, such as magnetic resonance imaging, or through muscle biopsies.
| Characteristics | Values |
|---|---|
| Definition | Muscular hypertrophy refers to an increase in muscle mass, size and strength |
| Cause | Strength training such as weight lifting |
| Types | Myofibrillar and sarcoplasmic |
| Process | Muscle hypertrophy occurs through an increase in the cross-sectional area of individual fibres |
| Training focus | Muscle size or muscle strength |
| Muscle fibre type | Resistance training increases the area of the fast-twitch type 2 fibres |
| Muscle fibre hypertrophy | Occurs through synthesis and accumulation of new myofilaments, with concomitant expansion of the fibre volume |
| Muscle cell increase | A range of stimuli can increase the volume of muscle cells |
| Muscle cell increase stimuli | Neural and muscular adaptations which increase the capacity of an athlete to exert force through voluntary muscular contraction |
| Muscle cell increase process | The muscle tissue expands by creating sarcomeres (contractile elements) and increasing non-contractile elements like sarcoplasmic fluid |
| Muscle stretching | When muscles are stretched to a greater-than-normal length, new sarcomeres are added at the ends of muscle fibres where they attach to the tendons |
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What You'll Learn
- Resistance training increases the area of fast-twitch type 2 fibres
- Muscle hypertrophy occurs when muscles are stretched beyond their normal length
- Muscle hypertrophy is an increase in muscle mass
- Myofibrillar hypertrophy increases myofibril size
- Muscle hypertrophy is a compensatory reaction to increased workload

Resistance training increases the area of fast-twitch type 2 fibres
Muscle hypertrophy refers to an increase in muscle mass, which usually manifests as an increase in muscle size and strength. This increase in muscle mass can be achieved through strength training, such as weight lifting, or resistance training.
The increase in muscle fibre cross-sectional area (CSA) is due to increases in fibre size and/or fibre number (hyperplasia). Resistance training increases the area of individual fibres, particularly type 2 fibres. Fibre hypertrophy occurs through the synthesis and accumulation of new myofilaments, with a concomitant expansion of fibre volume.
Muscle hypertrophy can also occur when muscles are stretched beyond their normal length, causing new sarcomeres to be added at the ends of muscle fibres. This results in an increase in muscle volume and mass. Conversely, when a muscle remains shortened below its resting length, sarcomeres at the end of the muscle fibres disappear.
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Muscle hypertrophy occurs when muscles are stretched beyond their normal length
Research has found that isometric exercises (static contraction) that force muscles to work at longer muscle lengths translate to nearly three times as much muscle growth. For example, holding the stretch at the bottom of a dumbbell fly as opposed to holding the contraction at the top of the fly movement with our chests contracted.
Animal model studies have shown that stretching causes muscle growth without the need for muscle activation, mainly by the addition of sarcomeres in series. This type of hypertrophy is very rapid but also quickly reaches a plateau if the muscle length is not continually increased.
Exercises that emphasise longer muscle lengths can be more effective for muscle hypertrophy, applicable to both upper and lower body muscles. For example, when doing a deep squat instead of a half squat, your muscles experience more metabolic stress.
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Muscle hypertrophy is an increase in muscle mass
Muscle hypertrophy occurs when muscles are stretched beyond their normal length, causing new sarcomeres to be added at the ends of muscle fibres. This leads to an increase in the cross-sectional area of the muscle fibres, which is accompanied by an increase in muscle volume and mass. The process of muscle hypertrophy starts immediately after the first training session, but it takes a few weeks before it can be reliably measured.
Resistance training increases the area of the fast-twitch type 2 fibres. Fibre hypertrophy occurs through the synthesis and accumulation of new myofilaments, with a concomitant expansion of the fibre volume. Contractile protein synthesis occurs at a higher rate than that of protein degradation, leading to hypertrophy.
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Myofibrillar hypertrophy increases myofibril size
Muscle hypertrophy refers to an increase in muscle mass, which usually manifests as an increase in muscle size and strength. There are two types of muscle hypertrophy: myofibrillar and sarcoplasmic. Myofibrillar hypertrophy increases myofibril size, which is the primary focus of bodybuilding-related activities.
Myofibrillar hypertrophy occurs when there is an increase in the size of skeletal muscle through a growth in size of its component cells. This type of hypertrophy focuses on increasing the size of the myofibrils, which are the contractile elements within muscle fibres. The process of myofibrillar hypertrophy involves the synthesis and accumulation of new myofilaments, which leads to an increase in fibre volume. This type of hypertrophy is often a compensatory reaction to increased workload following loss or atrophy of surrounding myofibers.
Myofibrillar hypertrophy is particularly important for bodybuilders and individuals seeking to increase muscle size and strength. It is achieved through strength training or resistance training, which causes neural and muscular adaptations. These adaptations increase the capacity of an individual to exert force through voluntary muscular contraction.
In addition to resistance training, myofibrillar hypertrophy can also be influenced by other factors such as muscle length. When muscles are stretched beyond their normal length, new sarcomeres are added at the ends of muscle fibres, contributing to an increase in muscle fibre length and cross-sectional area. Conversely, when a muscle remains shortened below its resting length, sarcomeres at the end of the muscle fibres disappear.
Myofibrillar hypertrophy can be measured using modern imaging techniques such as magnetic resonance imaging (MRI) or through invasive procedures such as muscle biopsies. However, it takes at least a few weeks before muscle hypertrophy can be reliably detected using these methods.
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Muscle hypertrophy is a compensatory reaction to increased workload
Muscle hypertrophy occurs as a result of strength training, such as weight lifting, which increases the load on the muscle. This activates inducible agents such as IGF-1, leading to an increase in muscle volume and mass. The process of muscle hypertrophy starts immediately after the first training session, with an increased net muscle protein turnover. However, it takes a few weeks before muscle hypertrophy can be reliably measured using modern imaging techniques such as magnetic resonance imaging (MRI).
There are two types of muscle hypertrophy: myofibrillar and sarcoplasmic. Myofibrillar hypertrophy focuses on increasing myofibril size, while sarcoplasmic hypertrophy focuses on increased muscle glycogen storage. Some people adapt their training to target different types of muscle growth, such as prioritising muscle size or muscle strength.
Skeletal muscle hypertrophy can also occur when muscles are stretched beyond their normal length, causing new sarcomeres to be added at the ends of muscle fibres. This results in an increase in muscle fibre length and, consequently, an increase in muscle volume and mass.
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Frequently asked questions
Muscle hypertrophy is an increase in muscle mass, usually resulting in an increase in muscle size and strength.
Muscle hypertrophy occurs as a result of strength training, such as weight lifting or resistance training. This type of training increases the cross-sectional area of individual muscle fibres, leading to an increase in muscle volume and mass.
There are two main types of muscle hypertrophy: myofibrillar hypertrophy and sarcoplasmic hypertrophy. Myofibrillar hypertrophy focuses on increasing myofibril size, while sarcoplasmic hypertrophy focuses on increased muscle glycogen storage.
Strength training causes neural and muscular adaptations, increasing the capacity of an athlete to exert force through voluntary muscular contraction. This leads to an increase in muscle tissue and, ultimately, muscle hypertrophy.
While the process of muscle hypertrophy starts immediately after the first training session, it takes a few weeks before muscle hypertrophy can be reliably measured using modern imaging techniques such as magnetic resonance imaging (MRI).











































