Dominic Stone
Inflammation is a natural process that can help tackle infections and promote muscle regeneration after an injury. However, uncontrolled inflammation can lead to muscle loss and weakness, contributing to various diseases such as rheumatoid arthritis and sarcopenia, a condition associated with ageing. Fortunately, research suggests that exercising our muscles can help reduce this harmful inflammation. A recent study by biomedical engineers at Duke University has demonstrated that human muscle has an innate ability to combat chronic inflammation when exercised. This discovery highlights the potential for muscle exercise to mitigate the damaging effects of inflammation and improve overall health.
| Characteristics | Values |
|---|---|
| Muscle cells can control inflammation | Muscle cells are capable of controlling inflammation by themselves |
| Exercise helps to reduce inflammation | Evidence suggests that regular exercise can help counter the effects of inflammation |
| Muscle growth | Stimulating muscle growth can reduce inflammation |
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What You'll Learn
Muscle cells can control inflammation independently
The study, published in the journal Science Advances, used lab-grown, engineered human muscle to demonstrate the potential power of the first-of-its-kind platform in such research endeavours. According to Nenad Bursac, a professor of biomedical engineering at Duke and the senior author of the research paper, it is difficult to determine which systems and cells are doing what inside an active person.
The study also found that muscle has an innate ability to ward off the damaging effects of chronic inflammation when exercised. This is good news for people suffering from illnesses where inflammation plays a role, such as rheumatoid arthritis and sarcopenia, which is muscle wasting associated with ageing. Evidence suggests that regular exercise can help counter the effects of inflammation in ageing, also known as "inflammaging".
In addition, the current stimulated muscle growth and reduced the muscle-wasting and weakening effects of interferon-gamma. The scientists managed to pinpoint the exact molecular pathway responsible for these effects on inflammation in muscles.
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Exercise can reduce chronic inflammation
A new study suggests that when exercised, our muscles have an innate ability to reduce harmful inflammation. This is because inflammation is a mixed blessing. In the short term, it tackles infections and promotes muscle regeneration after an injury. However, persistent inflammation plays a part in many illnesses, including rheumatoid arthritis and sarcopenia, which is muscle wasting associated with ageing.
Regular exercise can help counter the effects of inflammation in ageing, also known as "inflammaging". Staying fit and active reduces the long-lasting, or chronic, inflammation known to increase the risk of many diseases that affect older people.
Most researchers had assumed that inflammation is reduced by molecular cross-talk between muscle fibres and other cells in muscle tissue, such as fat cells and immune cells. However, a new study from Duke University suggests that muscle cells are perfectly capable of controlling inflammation by themselves.
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Muscle growth can reduce inflammation
The study used lab-grown, engineered human muscle to demonstrate the potential power of the first-of-its-kind platform in such research endeavours. The results showed that muscle has an innate ability to ward off the damaging effects of chronic inflammation when exercised.
In the short term, inflammation tackles infections and promotes muscle regeneration after an injury. However, persistent inflammation plays a part in many illnesses, including rheumatoid arthritis and sarcopenia, which is muscle wasting associated with ageing.
Evidence suggests that regular exercise can help counter the effects of inflammation in ageing, also known as "inflammaging". Staying fit and active reduces the long-lasting, or chronic, inflammation known to increase the risk of many diseases that affect older people.
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Exercise can reduce the risk of diseases associated with inflammation
The study, published in the journal *Science Advances*, used lab-grown, engineered human muscle to demonstrate the potential power of the first-of-its-kind platform in such research endeavours. The scientists also managed to pinpoint the exact molecular pathway responsible for these effects on inflammation in muscles.
The findings have important implications for reducing the risk of diseases associated with inflammation. Inflammation plays a role in muscle loss and weakness in many diseases, including rheumatoid arthritis and sarcopenia, which is muscle wasting associated with ageing. Regular exercise can help counter the effects of inflammation in ageing, also known as "inflammaging".
Staying fit and active reduces the long-lasting, or chronic, inflammation known to increase the risk of many diseases that affect older people. Therefore, exercise can be a powerful tool in reducing the risk of diseases associated with inflammation.
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Molecular cross-talk between muscle fibres and other cells can reduce inflammation
Most researchers had assumed that inflammation is reduced by molecular cross-talk between muscle fibres and other cells in muscle tissue, such as fat cells and immune cells. However, a new study from biomedical engineers at Duke University suggests that muscle cells are capable of controlling inflammation by themselves.
The study used lab-grown, engineered human muscle to demonstrate the potential power of the first-of-its-kind platform in such research endeavours. The results, which were published in the journal *Science Advances*, suggest that when exercised, muscles have an innate ability to reduce harmful inflammation.
This is significant because uncontrolled inflammation plays a role in muscle loss and weakness in many diseases, including rheumatoid arthritis and sarcopenia, which is muscle wasting associated with ageing.
The scientists managed to pinpoint the exact molecular pathway responsible for these effects on inflammation in muscles.
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Frequently asked questions
Muscles have an innate ability to reduce inflammation when exercised.
Inflammation is a mixed blessing. In the short term, it tackles infections and promotes muscle regeneration after an injury. However, persistent inflammation plays a part in many illnesses, including rheumatoid arthritis and sarcopenia (muscle wasting associated with ageing).
Regular exercise can help counter the effects of inflammation in ageing, also known as "inflammaging". Staying fit and active reduces the long-lasting, or chronic, inflammation known to increase the risk of many diseases that affect older people.
Uncontrolled inflammation plays a role in muscle loss and weakness in many diseases, including rheumatoid arthritis.
