
The human body is a complex machine, powered by over 600 muscles that help us move, breathe and survive. These muscles are made of thousands of fibres, which contract and expand to allow for movement. The study of muscles and their functions is a fascinating area of science, with new research revealing the intricacies of muscle communication with the brain. The Muscles Alive! program, for instance, uses hands-on tools to demonstrate how muscles and the brain interact. This article will delve into the science of muscles, exploring their anatomy, functions, and the latest advancements in muscle research, providing insight into the remarkable world of these living, breathing tissues that power our every move.
| Characteristics | Values |
|---|---|
| Number of muscles in the human body | More than 600 |
| Types of movements | Voluntary, Involuntary |
| Muscle function | Movement, posture, body temperature, storing nutrients, stabilizing joints |
| Muscle composition | Soft tissue, thousands of small fibers |
| Muscle groups | Chest, leg, back, abductors, flexors, extensors |
| Muscle tissue | Skeletal, smooth, cardiac |
| Skeletal muscle composition | Connective tissue (endomysium, perimysium, epimysium), capillaries, nerve tissue, myofibrils (actin, myosin, support proteins) |
| Skeletal muscle weight | Approximately 40% of human body weight |
| Skeletal muscle protein content | 50 to 75% of body proteins |
| Muscle disorders | Muscle weakness, chronic pain, Cerebral Palsy, Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), Stroke |
| Muscle communication | Brain communicates with muscles, and vice versa |
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What You'll Learn

The human body has over 600 muscles
There are three main types of muscle: skeletal, smooth, and cardiac. Skeletal muscle, which is under our conscious control, is the specialised tissue attached to bones that allows movement. It accounts for over 650 different muscles and is found in all areas of the body. Generally, skeletal muscles are grouped into opposing pairs, such as the biceps and triceps. Smooth muscle, on the other hand, is involuntary and is located in various internal structures, including the digestive tract, uterus, and blood vessels. It occurs on a cellular level, meaning there can be billions of smooth muscle cells. Cardiac muscle is also involuntary and is specific to the heart. It is organised into fibres and has a striated appearance, with individual cells closely connected to enable the heart to beat in a coordinated fashion.
Muscles are made up of thousands of elastic fibres bundled together. Each bundle is wrapped in a thin membrane called a perimysium, and an individual muscle fibre is made up of blocks of proteins called myofibrils, which contain a specialised protein (myoglobin) and molecules to provide the oxygen and energy required for muscle contraction. When stimulated, these fibres fold together, shortening the length of the muscle fibre and, in turn, the entire muscle.
Muscles work by either contracting or relaxing to cause movement, and this movement may be voluntary or involuntary. Glucose from carbohydrates in our diet fuels our muscles, but muscle tissue also needs particular minerals, electrolytes, and other dietary substances such as calcium, magnesium, potassium, and sodium to function properly.
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Skeletal muscle is a highly organised tissue
Bundles of myofibers form fascicles, and these bundles of fascicles make up muscle tissue. Skeletal muscle fibres are striated, multinucleated cells ranging from 10 to 100 micrometres in diameter and several centimetres long. The nuclei are located in the cell's periphery, adjacent to the sarcolemma, which is a tubular sheath that encases and defines each muscle fibre. The sarcolemma forms a barrier between the extracellular and intracellular compartments and is made up of a plasma membrane and a polysaccharide coating that fuses with tendon fibres.
Each muscle is made up of multiple tissues, including blood vessels, lymphatics, contractile muscle fibres, and connective tissue sheaths. The outermost layer of connective tissue covering each muscle is called the epimysium. Within each muscle, there are groups of muscle fibres called fascicles, which are surrounded by a connective tissue layer called the perimysium. Each fascicle contains multiple units of individual muscle fibres, which are surrounded by endomysium, another type of connective tissue sheath.
The two most essential myofilaments that make up the contractile elements of the muscle fibre are actin and myosin, which are arranged in a striated pattern to form the dark A band, the light I band, and the fundamental unit of contraction, or sarcomere. The sarcomere consists of a central M line, with thick myofilaments of myosin attached to either side. Skeletal muscles are voluntary muscles, meaning an individual can control how and when they move and work.
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The brain communicates with muscles
At the end of each motor neuron is a neuromuscular junction, where the neuron connects to a muscle fibre. Here, the motor neuron releases a chemical that is picked up by the muscle fibre, triggering it to contract. This contraction of muscle fibres is what ultimately produces movement in the body. The neuromuscular system, encompassing all the muscles and nerves serving them, facilitates this intricate communication and coordination between the brain and muscles.
The brain's role in muscle movement is primarily managed by the primary motor cortex, which is responsible for voluntary muscle actions. Different portions of the motor cortex correspond to various body regions, with areas involved in more complex motions occupying larger sections. When a movement is initiated, neurons in the relevant part of the motor cortex send signals through the corticospinal tract to the spinal cord, where they connect with lower motor neurons that extend to other body parts.
Additionally, muscle memory, a form of procedural memory, plays a role in the brain's communication with muscles. While muscles themselves do not remember, the nervous system stores and accesses information about practiced physical actions. This allows for the automation of tasks with repeated practice, as the brain no longer needs to consciously direct every detail of an action.
The study of neuromuscular interactions and muscle memory has led to the development of programs like "Muscles Alive!", which aims to educate people of all ages about how the brain and muscles communicate. Through hands-on demonstrations and experiments, participants can visualise and experience their brain's commands to their muscles, enhancing their understanding of this fascinating aspect of human physiology.
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Intrinsic and extrinsic hand muscles
The intrinsic and extrinsic muscles of the hand are responsible for various functions, including finger movement, grasping, and fine motor control.
Intrinsic hand muscles are located within the hand itself and are responsible for fine motor functions. These muscles include the adductor pollicis, the opponens digit minimi, the abductor digiti minimi, the flexor digitorum superficialis, and the flexor digiti minimi brevis. The deep flexor attaches to the distal phalanx, and the superficial flexor attaches to the middle phalanx. The flexors are responsible for bending the fingers. The intrinsic muscles also include the thenar muscles, which are involved in moving the thumb in opposition, enabling grasping.
The hypothenar muscles form a muscular protrusion on the medial side of the palm, at the base of the little finger. These muscles are similar in name and organisation to the thenar muscles. The ulnar nerve innervates the hypothenar muscles. The lumbricals are another important group of intrinsic muscles. There are four lumbricals in the hand, each associated with a finger, and they are crucial for finger movement. They link the extensor tendons to the flexor tendons and assist in flexion at the metacarpophalangeal (MCP) joints and extension at the interphalangeal (IP) joints. The interossei muscles are located between the metacarpal bones of the hand and can be divided into dorsal and palmar groups. They assist the lumbricals in abduction and adduction of the fingers, respectively.
The extrinsic hand muscles include the finger extensors and the thumb abductor, which extend at the wrist and metacarpophalangeal joints and abduct and extend the thumb. These muscles are innervated by the radial nerve. The median nerve innervates the flexors of the wrist and digits, the abductors and opponens of the thumb, and the first and second lumbricals. The ulnar nerve innervates the remaining intrinsic muscles of the hand, including the third and fourth lumbricals.
The development of intrinsic hand muscles begins during embryonic stages, with myogenic progenitor cells dividing into superficial and deep layers, contributing to the formation of these muscles. The nerves of the intrinsic hand, including the median and ulnar nerves, arise from the brachial plexus, a network of nerves from ventral rami between the C5 to T1 nerve roots.
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Facial muscles and the EMG of smiling
The human face has about 20 facial muscles, which are essential for chewing, making facial expressions, and performing other tasks. These muscles are located throughout the face, including the ears, mouth, forehead, nose, and eyes.
The zygomaticus major is a crucial facial muscle responsible for smiling and emotional expression. This muscle sits between the corners of our lips and the upper part of our cheeks, controlling the way we smile. The activation of the zygomaticus major on both sides of the face creates a smile, whether spontaneous and genuine (a "Duchenne" smile) or planned and deliberate (a "non-Duchenne" smile"). The orbicularis oculi, which is the muscle around the lips that causes the raising of the cheeks, is also involved in a genuine Duchenne smile.
The most common way to measure activity in this region is to use fEMG (facial electromyography). By placing electrodes along the muscle, the activity can be measured by detecting the electric impulses that result in muscle activation. Research using fEMG has shown that the activation of the zygomaticus major is not necessarily exclusively linked to the generation of positive emotions. For example, smiles can be wry, sarcastic, or smirking, and not always expressions of true positive feeling.
The Human EMG Spikerbox, developed through a collaboration between Dr. Tracy and Backyard Brains, Inc., allows inexpensive, portable, and accessible electromyogram recordings. The Spikerbox is a key component of the Muscles Alive! program, an interactive, immersive, and fun science education initiative. With the Spikerbox, participants can see and hear their electromyogram in real time while they activate their muscles, allowing them to experience their brain's signals to the muscles.
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Frequently asked questions
A muscle is a soft tissue in the body made up of thousands of small fibres woven together. These fibres stretch and press together to move your body and your organs. There are more than 600 muscles in the human body.
Muscles perform two types of movements: voluntary and involuntary. Voluntary movements are actions you control, like sprinting or scrolling on your phone. Involuntary movements happen automatically, like the movement of your organs to keep your body functioning.
The brain communicates with muscles through electrical signals called EMGs (electromyograms). These signals are made up of the action potentials from groups of muscle fibres.
It's normal to feel muscle soreness after a workout, but chronic muscle pain or weakness could be a sign of something more serious. Visit a healthcare provider if you experience muscle pain for more than a week, or if you have trouble moving.






































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