
Muscle mass is a part of lean body mass, which includes muscle, skin, bone, water, and organ mass. Skeletal muscle is the most common type of muscle in the body, comprising 30-40% of total body mass. It is under voluntary control, allowing for a wide range of movements and functions. Cardiac and smooth muscle, on the other hand, contract involuntarily. Muscle mass is important for mobility, balance, and strength, and it can be estimated using medical equipment, body fat calculations, and measurements. Maintaining muscle mass is key to overall health, and while there are no specific guidelines for ideal muscle mass percentages, a healthy body fat percentage can indicate overall body composition.
| Characteristics | Values |
|---|---|
| Muscle composition | Muscle mass, fat, bone, water, and organ mass |
| Muscle mass percentage | No specific guidelines for what a healthy or normal muscle mass percentage should be |
| Muscle mass calculation | Imaging tests, D-creatine dilution, MRI, Bioelectrical Impedance Analysis (BIA), body fat scale |
| Muscle types | Skeletal, cardiac, and smooth muscle |
| Skeletal muscle composition | Tendons, perimysium, striated muscle, actin, myosin, troponin, tropomyosin |
| Skeletal muscle mass | 30% to 40% of total body mass |
| Skeletal muscle control | Voluntary, controlled by somatic nervous system |
| Cardiac muscle composition | Makes up the main tissue of the heart's walls |
| Cardiac muscle control | Involuntary, controlled by autonomic nervous system |
| Smooth muscle composition | N/A |
| Smooth muscle control | Involuntary, controlled by autonomic nervous system |
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What You'll Learn

Muscle mass percentage
There are various ways to estimate muscle mass percentage, including using medical equipment, calculating body fat percentage, and measuring certain areas of the body. While it is challenging to determine exact muscle mass percentage without expensive technology, such as imaging tests like MRI scans, there are other tools, formulas, scales, and calculators that can provide an estimation of muscle mass. These include body fat scales and measuring the circumferences of various body parts, as recommended by the United States Navy.
Maintaining a healthy muscle mass has several benefits. It can help older adults stay mobile, maintain a healthy weight, and reduce the risk of injuries. Additionally, building muscle mass can increase bone density and may have psychological and cognitive benefits, although more research is needed in this area. Higher muscle mass may also present some challenges, such as difficulty finding well-fitting clothing and increased calorie requirements to feel full.
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Lean body mass
LBM is considered a superior index to total body weight for prescribing proper levels of medications and for assessing metabolic disorders, as body fat is less relevant for metabolism. For example, anesthesiologists use LBM to dose certain medications. The induction dose of propofol should be based on LBM, and opioids are best based on LBM to avoid postoperative opioid-induced ventilatory depression in obese patients.
LBM can be estimated using mathematical formulas. Several formulas exist, each with different utilities for different purposes. For example, the Boer formula is the method of choice for LBM estimation to calculate the dose given in contrast CT in obese individuals with a BMI between 35 and 40. LBM can also be estimated using a lean body mass calculator, which computes a person's estimated LBM based on body weight, height, gender, and age.
It is important to distinguish between lean body mass and muscle mass. While the two terms are often used interchangeably, they are not the same. Muscle mass is a part of lean body mass, which also includes skin, bone, water, and organ mass. Muscle mass refers specifically to the weight and size of smooth muscle tissue in the body, including skeletal, smooth, and cardiac muscles. When people talk about gaining muscle, they are typically referring to skeletal muscle, which is the only muscle type that can be actively grown through exercise and nutrition.
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Skeletal muscle
Each skeletal muscle is made up of muscle fibres, also known as myofibers, which are long and cylindrical in shape. These fibres are formed from the fusion of myoblasts, resulting in long multinucleated cells. Each fibre is surrounded by a thin layer of connective tissue called the endomysium, which is composed of collagen and reticular fibres. The endomysium plays a crucial role in transferring the force produced by the muscle fibres to the tendons.
The muscle fibres are composed of myofibrils, which are made up of actin and myosin filaments, also known as thin and thick filaments, respectively. These filaments are arranged in repeated units called sarcomeres, which are the basic functional units of the muscle fibre, necessary for muscle contraction. The sarcomeres are highly organised, consisting of contractile, regulatory, and structural proteins. The shortening of these sarcomeres leads to the contraction of individual muscle fibres and, ultimately, the whole muscle.
The composition of muscle fibre types is influenced by both genetic and environmental factors. For example, in zebrafish embryos, the Prdm1 gene down-regulates the formation of new slow-twitch fibres, while in mice, this gene does not control slow muscle genes. Additionally, environmental factors such as water temperature can impact the expression of different fibre types, with cold temperatures favouring fatigue resistance and tropical environments benefiting from fast and powerful movements.
The strength of skeletal muscles is determined by their cross-sectional area. The strongest muscles in the body, such as the quadriceps femoris or the gluteus maximus, have the largest cross-sectional areas. Shorter muscles are generally stronger "pound for pound" compared to longer muscles with the same cross-sectional area.
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Smooth and cardiac muscle
There are three types of muscles in the human body: skeletal, smooth, and cardiac. Smooth and cardiac muscles are involuntary muscles controlled by the autonomic nervous system, meaning they work without conscious effort.
Smooth muscle is found in the walls of all visceral organs, except the heart. It lines the inside of some organs and performs essential functions like moving waste through the intestines and helping the lungs expand during breathing. Smooth muscle is also found in the female and male reproductive systems, urinary system, respiratory system, and digestive system. Smooth muscle tissue can undergo hypertrophy to increase in size, and it can also divide to produce more cells, a process called hyperplasia. This process is evident in the uterus during puberty, where increased estrogen levels lead to more uterine smooth muscle fibers and a larger myometrium.
Cardiac muscle, also known as myocardium, is found only in the walls of the heart, making up its middle layers. It contains a high number of mitochondria, which produce ATP for energy and help the heart resist fatigue. Cardiac muscle cells are extensively branched and connected at their ends by intercalated discs, allowing them to contract in a wave-like pattern, enabling the heart to pump blood effectively. The contraction of cardiac muscle is involuntary and controlled by specialized cardiac muscle cells called pacemaker cells, which respond to signals from the autonomic nervous system to regulate heart rate.
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Body composition
There are various methods to estimate muscle mass percentage, including the use of medical equipment, calculating body fat percentage, and measuring certain areas of the body. The most accurate ways to determine muscle mass involve expensive medical equipment, such as imaging tests and MRI scans. However, there are also cost-effective scales and calculators that can be used at home or in a gym to estimate body composition. It is important to note that different measuring tools can provide varying results for the same person.
The body has three types of muscles: skeletal, smooth, and cardiac. Skeletal muscle is the most common type, comprising 30% to 40% of total body mass. It is under voluntary control and allows for a wide range of movements and functions. Smooth muscle and cardiac muscle contract involuntarily, with smooth muscle autonomously controlling functions such as the urinary system, and cardiac muscle making up the main tissue of the heart's walls.
Muscle mass refers specifically to the weight and size of smooth muscle tissue in the body. Skeletal muscle mass varies from person to person, with males generally having more skeletal muscle mass than females. Taller people and those with overweight tend to have higher muscle mass. Additionally, muscle mass decreases with age.
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Frequently asked questions
Muscle composition refers to the amount of soft muscle tissue in the body, including skeletal and smooth muscles. Skeletal muscle is the most common type of muscle in the body and is under voluntary control. Smooth muscle contracts autonomously, or without any conscious thought.
There are various ways to estimate muscle mass percentage. The most accurate ways involve expensive medical equipment such as MRI scans. It is also possible to estimate muscle mass percentage at home using body fat scales or calculators.
Maintaining a healthy percentage of muscle mass has several benefits, such as reducing the risk of age-related muscle loss and improving overall metabolism. Higher muscle mass may also have psychological and cognitive benefits, although more research is needed.
The two main types of skeletal muscle are slow-twitch and fast-twitch. Slow-twitch muscles can contract for a long time without much effort, using carbohydrates and fats as fuel. Fast-twitch muscles can contract rapidly and with a lot of force, but the contraction is short-lived.











































