
There are over 600 muscles in the human body, and they all work together to move you and support your body. Muscles are made of thousands of small fibres woven together, and they come in three types: skeletal, smooth, and cardiac. Skeletal muscles are attached to bones and allow movement, smooth muscles are located in various internal structures like the digestive tract, and cardiac muscles are specific to the heart. Together, the brain, nerves, and skeletal muscles cause movement, and this is known as the neuromuscular system.
| Characteristics | Values |
|---|---|
| Number of muscles in the human body | 600 |
| Muscle composition | Thousands of elastic fibres bundled tightly together |
| Muscle tissue composition | Actin, myosin, troponin, tropomyosin, myoglobin, calcium, magnesium, potassium, sodium |
| Muscle types | Skeletal, smooth, cardiac |
| Skeletal muscle shapes | Spindle, flat, triangular, circular |
| Skeletal muscle fibre types | Type I (slow-twitch), Type II (fast-twitch) |
| Muscle movement types | Voluntary, involuntary |
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What You'll Learn

Skeletal muscle is attached to bones and allows movement
Skeletal muscles are attached to bones and enable movement. They are the most common type of muscle in the human body, with about 600 muscles in total. They are attached to bones by tendons and together they produce all body movements. The brain, nerves, and skeletal muscles work together to cause movement, and this is collectively known as the neuromuscular system.
Skeletal muscles are under conscious control, and are therefore also known as voluntary muscles. They are made up of thousands of elastic fibres bundled tightly together. Each bundle is wrapped in a thin transparent membrane called a perimysium. Each muscle fibre is made up of blocks of proteins called myofibrils, which contain a specialised protein (myoglobin) and molecules to provide the oxygen and energy required for muscle contraction.
The brain sends a message to the motor neurons, which triggers the release of the chemical acetylcholine from the presynaptic terminals. The muscle responds by contracting. Skeletal muscles are broadly classified into two fibre types: type I (slow-twitch) and type II (fast-twitch). Type I, slow-twitch, slow oxidative, or red muscle is dense with capillaries and is rich in mitochondria and myoglobin, giving the muscle tissue its characteristic red colour. It can carry more oxygen and sustain aerobic activity.
The musculoskeletal system is one of the body's major tissue/organ systems. It comprises bones, muscles, and joints, and enables us to do everyday physical activities. Skeletal muscles are grouped into opposing pairs such as the biceps and triceps on the front and back of the upper arm.
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Smooth muscle is located in the digestive tract, uterus, and blood vessels
Smooth muscle is a type of muscle that is located in various internal structures of the human body, including the digestive tract, uterus, and blood vessels. It is different from skeletal and cardiac muscle in terms of function but shares the same basic composition. Smooth muscle is made up of thousands of elastic fibres bundled together, with each bundle wrapped in a thin membrane called a perimysium.
Smooth muscle in the digestive tract, or gastrointestinal smooth muscle, produces tonic contractions that maintain organ dimension and forceful contractions that propel food along the gastrointestinal tract. Smooth muscle in the intestinal wall helps maintain organ dimension against an imposed load, such as a bolus of food.
Smooth muscle is also found in the uterus, where it is known as the myometrium. During pregnancy, the myometrium stretches to accommodate the growing uterus and contracts during labour. After delivery, the myometrium contracts to expel the placenta, and the crisscrossing fibres of the middle layer compress the blood vessels to minimize blood loss.
Smooth muscle in blood vessels, or vascular smooth muscle, makes up most of the walls of blood vessels and is primarily innervated by the sympathetic nervous system through adrenergic receptors. It contracts or relaxes to change the volume of blood vessels and regulate local blood pressure, redistributing blood within the body to areas with enhanced oxygen consumption.
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Cardiac muscle is specific to the heart
Cardiac muscle, also called the myocardium, is one of three types of muscle tissues in the body, the others being skeletal and smooth muscle. It is an involuntary, striated muscle that constitutes the main tissue of the wall of the heart. The cardiac muscle forms a thick middle layer between the outer layer of the heart wall (the pericardium) and the inner layer (the endocardium).
The cardiac muscle is composed of individual cardiac muscle cells, known as cardiomyocytes, which are joined by intercalated discs. These cardiomyocytes are striated, branched, and contain many mitochondria. They are under involuntary control and have their own pacemaker cells, such as the sinoatrial (SA) node, which spontaneously depolarizes. This allows the heart to contract and relax without conscious awareness. The contraction of the cardiac muscle is vital for pumping blood throughout the cardiovascular system.
The individual cardiac muscle cell is a tubular structure composed of chains of myofibrils, which are rod-like units within the cell. The myofibrils consist of repeating sections of sarcomeres, which are the fundamental contractile units of the muscle cells. Sarcomeres are composed of long proteins that organize into thick and thin filaments, called myofilaments. Thin myofilaments contain the protein actin, and thick myofilaments contain the protein myosin. The myofilaments slide past each other as the muscle contracts and relaxes, producing the formation of "cross-bridges", which cause the contraction of the heart and the generation of force.
The release of calcium from the sarcoplasmic reticulum (SR) triggers the process of excitation-contraction coupling, which causes the myofilaments to slide past each other. The concentration of calcium in the myocyte determines how much force is generated with each contraction. The cardiac muscle must contract with enough force and blood to supply the metabolic demands of the entire body.
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Muscle tissue contains contractile proteins actin and myosin
Muscle tissue is a specialised contractile tissue that is a distinguishing characteristic of animals. There are about 600 muscles in the human body, and they work by contracting or relaxing to cause movement. This movement may be voluntary or involuntary. Muscle tissue contains contractile proteins called actin and myosin, which interact to cause movement.
Actin and myosin are the two most essential myofilaments that make up the contractile elements of the muscle fibre. Myosin is a thick filament, while actin is thin. The sarcomere consists of a central M line, with thick myosin filaments attached to either side. The thin actin filaments project towards each other from the Z-line, partially overlapping the myosin filaments. The interaction of myosin and actin proteins is at the core of our current understanding of sarcomere shortening.
The sliding filament theory, proposed in 1954, states that the sliding of actin past myosin generates muscle tension. The bending of the myosin S1 region helps explain how myosin moves or "walks" along actin. The myosin reaches forward, binds to actin, contracts, releases actin, and then reaches forward again to bind actin in a new cycle. This process is known as myosin-actin cycling.
The regulatory proteins troponin and tropomyosin are also present in muscle tissue. Tropomyosin is a fibrous protein that binds lengthwise along the groove of actin filaments. Troponin is a complex of three polypeptides: troponin C (Ca2+-binding), troponin I (inhibitory), and troponin T (tropomyosin-binding). When the concentration of Ca2+ is low, the complex of the troponins with tropomyosin blocks the interaction of actin and myosin, so the muscle does not contract. At high concentrations, Ca2+ binding to troponin C shifts the position of the complex, allowing contraction to proceed.
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Muscle disorders may cause weakness, pain, or paralysis
The human body has about 600 muscles, which work by contracting or relaxing to enable movement. The brain, nerves, and skeletal muscles work together to cause movement, and this is collectively known as the neuromuscular system. The musculoskeletal system, also known as the locomotor system, includes skeletal muscles and bones. Skeletal muscles are under conscious control and are also known as voluntary muscles. They are attached to bones and allow movement.
Smooth muscle, on the other hand, is located in various internal structures, including the digestive tract, uterus, and blood vessels. It is arranged in layered sheets that contract in waves along the length of the structure. Smooth muscle contracts involuntarily, without conscious intervention. Cardiac muscle is the third type of muscle, and it is specific to the heart. Like smooth muscle, it contracts involuntarily.
Muscle disorders, or myopathy, may cause weakness, pain, or even paralysis. Muscle weakness can be a symptom of many chronic conditions and acute infections, or a side effect of certain medications. Determining the cause of muscle weakness can be challenging, and it should be differentiated from subjective fatigue or pain-related motor impairment with normal motor strength. A formal tool such as the Medical Research Council Manual Muscle Testing scale can be used to grade muscle weakness objectively.
Numerous factors can cause muscle weakness, including sleep disorders, endocrine disorders, electrolyte imbalances, and muscular dystrophy. Sleep disorders such as narcolepsy and insomnia can result in daytime muscle weakness and fatigue. Endocrine disorders such as hyperthyroidism, hypothyroidism, and adrenal insufficiency can also cause muscle weakness. Electrolyte imbalances, including disturbances in calcium, phosphate, potassium, and sodium, can lead to muscle weakness. Hypokalemia, for example, can cause periodic paralysis. Muscular dystrophy, a genetic disorder, usually presents during childhood or adolescence, but certain subtypes can manifest in adulthood.
In addition to these factors, exposure to toxins, such as heavy metals or organophosphates, can cause muscle weakness or even paralysis. Alcohol and certain recreational drugs, such as cocaine and amphetamines, can also lead to muscle weakness. Furthermore, infectious conditions like the flu, Lyme disease, and meningitis can cause muscle weakness.
Muscle pain or myalgia can also be caused by various factors, including muscle strain or sprain, injury, or inflammation. Muscle pain can also be a symptom of underlying medical conditions, such as fibromyalgia or rheumatoid arthritis.
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Frequently asked questions
TDE stands for Total Daily Energy Expenditure, which is the number of calories your body burns in a day. This includes calories burned during exercise and physical activity, but also those burned during rest. Muscle plays a key role in TDE as the more muscle mass you have, the higher your TDE.
Muscles are soft tissue made up of thousands of elastic fibres bundled tightly together. There are about 600 muscles in the human body.
There are three types of muscle tissue in vertebrates: skeletal, smooth, and cardiac.
Skeletal muscles are part of the musculoskeletal system, working with bones, tendons, and ligaments to support the body and enable movement. They are under conscious control, so they are also known as voluntary muscles.
Smooth muscle is located within the walls of organs and structures such as the esophagus, stomach, intestines, and blood vessels. Smooth muscles are involuntary, contracting without conscious intervention.
Cardiac muscle is the muscle of the heart, contracting and relaxing involuntarily to pump blood throughout the cardiovascular system.











































