
Muscle relaxers, or muscle relaxants, are medications used to treat muscle spasms or muscle spasticity. Muscle spasms or cramps are sudden, involuntary contractions of a muscle or group of muscles, often caused by too much muscle strain. They can lead to pain and are associated with conditions such as lower back pain, neck pain, and fibromyalgia. Muscle spasticity, on the other hand, is a continuous muscle spasm that causes stiffness, rigidity, or tightness, interfering with normal movement. It is caused by injury to parts of the brain or spinal cord involved with movement and can be seen in conditions such as multiple sclerosis (MS) and cerebral palsy. While prescription medications are available to treat these conditions, there are also over-the-counter (OTC) options that can provide relief.
| Characteristics | Values |
|---|---|
| Type | Prescription medications, Over-the-counter medications |
| Drug classes | Antispastics, Antispasmodics |
| Prescription medications | Tizanidine, Baclofen (Lioresal), Dantrolene (Dantrium), Diazepam (Valium), Carisoprodol (Soma, Vanadom) |
| Over-the-counter medications | NSAIDs (Nonsteroidal anti-inflammatory drugs), Naproxen, Ibuprofen (Advil, Motrin), Acetaminophen |
| Prescription medication effects | Muscle relaxation, Sedative effect, Prevents nerves from sending pain signals to the brain |
| Over-the-counter medication effects | Muscle-relaxing effects, Reduces pain from muscle tension |
| Prescription medication uses | Treat muscle spasticity, Treat muscle spasms, Treat musculoskeletal pain |
| Over-the-counter medication uses | Treat muscle soreness, Treat aches and pains associated with muscle spasms |
| Side effects | Drowsiness, Decreased muscle tone, Nausea, Extreme tiredness, Lack of energy, Loss of appetite, Unusual bleeding or bruising, Pain in the upper right part of the stomach, Yellowing of skin or eyes, Flu-like symptoms, Rash, Hives, Itching, Swelling of the face, throat, tongue, lips, or eyes, Shortness of breath, Difficulty breathing or swallowing |
| Treatment duration | Short-term (2-3 weeks) |
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What You'll Learn
- Muscle relaxants are the third most prescribed medication for lower back pain
- Cyclobenzaprine is a medication that relaxes muscles and reduces stiffness
- Tizanidine is a skeletal muscle relaxant that treats muscle spasms, cramping, and tightness
- THC, a compound in cannabis, acts as a muscle relaxant but requires more research
- Muscle relaxers can cause drowsiness, so you shouldn't drive while taking them

Muscle relaxants are the third most prescribed medication for lower back pain
Muscle relaxants are prescription medications that help regulate muscle contraction (tightening) to reduce pain and discomfort caused by muscle spasms and muscle spasticity (stiffness). They are generally safe and well-tolerated when used short-term at recommended doses. Sedation and drowsiness are the most commonly reported side effects. Muscle relaxers are categorised based on their ability to treat stiffness, spasms, or both.
Healthcare providers prescribe muscle relaxants to treat several symptoms, such as muscle spasms, spasticity, and musculoskeletal pain. Muscle relaxants alleviate pain by reducing muscle spasms and tensions. They are prescribed when there is severe pain, discomfort, and/or functional disability due to muscle spasms or stiffness. Oral muscle relaxants are more commonly prescribed because they are convenient to take and do not require needles.
There are two major drug classes of muscle relaxants: antispastics and antispasmodics. These classes differ in their uses, ways of working, and side effects. Antispastic skeletal muscle relaxants that providers can currently prescribe include baclofen (Lioresal) and dantrolene (Dantrium). Two skeletal muscle relaxants have both antispastic and antispasmodic effects: tizanidine (Zanaflex) and diazepam (Valium). Antispastic medications act on the spinal cord or skeletal muscle directly to improve muscle tightness (hypertonicity) and involuntary spasms. Antispasmodics decrease muscle spasms through changes in the central nervous system (brain and spinal cord).
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Cyclobenzaprine is a medication that relaxes muscles and reduces stiffness
Muscle relaxants are medications that help treat muscle spasms or spasticity. They are the third most prescribed medication for lower back pain. They are also used to treat muscle-related symptoms like stiffness and severe pain.
Cyclobenzaprine is not approved for use by anyone under the age of 15 and should be avoided by elderly patients due to the risk of more severe side effects, such as confusion, delirium, and cognitive impairment. It should not be used by those with certain medical conditions, such as hyperthyroidism or heart problems. It may also interact with other medications, such as MAO inhibitors and serotonergic drugs, increasing the risk of serotonin syndrome.
Some common side effects of cyclobenzaprine include dry mouth, drowsiness, dizziness, and agitation. It is important to follow the directions on the prescription label and read all medication guides or instruction sheets. If any side effects occur, it is recommended to consult a doctor or medical professional.
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Tizanidine is a skeletal muscle relaxant that treats muscle spasms, cramping, and tightness
Muscle relaxers, or muscle relaxants, are medications used to treat muscle spasms, spasticity, stiffness, and pain. They are the third most prescribed medication for lower back pain and can be prescribed following spine surgery or during physical therapy. They can be prescribed for short-term use to relieve pain caused by tense or spasming muscles and improve daily functioning.
Tizanidine (brand name Zanaflex®) is a prescription medication that belongs to a group of drugs called skeletal muscle relaxants. It is used to treat muscle spasms, cramping, and tightness. Tizanidine stimulates alpha-2 adrenergic receptors in the central nervous system, inhibiting the release of norepinephrine, a brain chemical that increases skeletal muscle contraction. By reducing the release of norepinephrine, tizanidine helps to reduce muscle spasticity, leading to reduced muscle tone and muscle relaxation.
Tizanidine is often prescribed to relieve increased muscle tone and muscle spasms in people with muscle spasticity, multiple sclerosis, and spinal cord injuries. It can be taken by mouth with water, with or without food, but this should be done consistently. It is important to follow the doctor's instructions and not change the dose or dosing interval without their approval. If you miss a dose of tizanidine, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
It is important to note that tizanidine can have side effects, including sleepiness, decreased ability to focus and concentrate, and, rarely, hallucinations. It can also cause liver damage, especially in those with a history of liver problems. It may also cause withdrawal symptoms such as nausea, vomiting, fast heartbeat, high blood pressure, and muscle tightening if stopped suddenly. Therefore, it is important to consult a doctor before starting or stopping this medication and to inform them of any other medications being taken.
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THC, a compound in cannabis, acts as a muscle relaxant but requires more research
Muscle relaxants are medications used to treat muscle spasms or muscle spasticity. Muscle spasms, or cramps, are sudden, involuntary contractions of a muscle or group of muscles, often caused by too much muscle strain. Muscle spasticity, on the other hand, is a continuous muscle spasm that causes stiffness, rigidity, or tightness that can interfere with normal movement.
Muscle relaxants are typically prescribed when there is severe pain, discomfort, and/or functional disability due to muscle spasms or stiffness. They help regulate muscle contraction (tightening) to reduce pain and discomfort. The term “muscle relaxant” refers to two major drug classes: antispastics and antispasmodics. Antispastics are used to treat muscle spasticity, while antispasmodics are used to treat muscle spasms.
THC, a compound in cannabis, has been found to have muscle-relaxing properties. Tetrahydrocannabinol (THC) is the substance responsible for the psychoactive effects of marijuana. It interacts with the body's endocannabinoid system (ECS), a complex network of receptors and molecules that play a role in regulating muscle function and pain perception. When THC binds to cannabinoid receptors in the brain and nervous system, it can reduce muscle spasticity, leading to a relaxation of the affected muscles and a decrease in the severity and frequency of muscle spasms.
While THC has shown promise in alleviating muscle spasticity, more research is needed to fully understand its effectiveness. Small clinical studies have been conducted, but the results are not conclusive. For example, in one study, researchers measured muscle tremors with a mechanical device, showing detectable changes in only two out of eight patients, despite seven reporting improved symptoms. The measuring techniques used in these studies may not have been sensitive enough to detect subtle improvements. Additionally, the cultivation, supply, and possession of cannabis are still prohibited in many areas, limiting the research on its medicinal properties.
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Muscle relaxers can cause drowsiness, so you shouldn't drive while taking them
Muscle relaxers are prescription medications that help regulate muscle contraction (tightening) to reduce pain and discomfort caused by muscle spasms and muscle spasticity (stiffness). They are the third most prescribed medication for lower back pain. Muscle relaxers are divided into two groups: antispastics and antispasmodics. Antispastics are used to treat muscle spasticity, while antispasmodics are used to treat muscle spasms.
Dantrolene, for example, can cause abdominal pain, dizziness, headaches, trouble breathing, drowsiness, and shakiness. Baclofen may lead to drowsiness, difficulty with eyesight, dizziness, weakness, headaches, difficulty breathing, confusion, shakiness, agitation, or anxiety. Diazepam can result in weakness, drowsiness, forgetfulness, light-headedness, confusion, and feelings of aggression.
If you need to take a muscle relaxant and drive, consult your doctor. They can prescribe a muscle relaxant relatively free of known side effects or advise on alternative treatments. It is important to discuss the risks and benefits of these medications with your healthcare provider. Remember, muscle relaxants are generally prescribed for short-term use (2-3 weeks), and potential side effects, medication interactions, and personal preferences are considered before choosing a specific muscle relaxant.
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Frequently asked questions
Muscle relaxers, or muscle relaxants, are medications used to treat muscle spasms or muscle spasticity. They are categorised based on their ability to treat stiffness, spasms, or both.
Prescription muscle relaxers include Baclofen (Lioresal), Dantrolene (Dantrium), Tizanidine (Zanaflex), and Diazepam (Valium).
Yes, over-the-counter medications such as NSAIDs (Non-steroidal Anti-inflammatory Drugs) and acetaminophen can help with muscle soreness and pain. Ibuprofen, Advil, and Motrin are some widely-used NSAIDs.
Muscle relaxers can cause drowsiness, so it is advised not to drive while taking them. Tizanidine, a prescription muscle relaxer, can decrease muscle tone, so caution is advised when performing activities that require balance and posture.











































