
Muscle inflammation, or myalgia, can be caused by a variety of factors, including muscle strain, viral and bacterial infections, medication side effects, and chronic conditions such as myopathies and fibromyalgia. While muscle pain is usually temporary and non-serious, it can be effectively managed using various medications and natural supplements. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen, and naproxen, are commonly used to treat muscle inflammation and related pain. NSAIDs can be purchased over the counter and are fast-acting with relatively mild side effects. However, long-term use of NSAIDs may cause harm, and they are not suitable for everyone. Alternative treatments for muscle inflammation include corticosteroids, physical therapy, gentle stretching, massage, and heat or cold therapy.
| Characteristics | Values |
|---|---|
| Type | Nonsteroidal anti-inflammatory drugs (NSAIDs) |
| Use | Reduce pain, fever, inflammation, stiffness |
| Availability | Over-the-counter (OTC) |
| Side effects | Stomach ulcers, gastrointestinal issues, nausea, vomiting, constipation, lightheadedness, balance issues, difficulty concentrating |
| Risk factors | Kidney disease, liver disease, GERD, Crohn's disease, ulcerative colitis, unmanaged diabetes, high blood pressure, bleeding disorders, heart failure, history of stroke or heart attack |
| Drug interactions | Warfarin, blood pressure medications, low-dose aspirin |
| Natural alternatives | Natural supplements, physical activity, gentle stretching, massage, cold therapy, heat therapy |
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What You'll Learn

Nonsteroidal anti-inflammatory drugs (NSAIDs)
NSAIDs are intended for occasional and short-term use. They can cause side effects, especially with frequent use and higher dosages. The most frequently reported side effects are gastrointestinal issues, such as feeling bloated, stomach pain, nausea, vomiting, and constipation. NSAIDs can also cause more serious side effects, including an increased risk of heart attack and stroke, even in healthy people. People with cardiovascular disease are at a particularly high risk of developing heart-related issues from taking NSAIDs.
To reduce the risk of gastrointestinal symptoms, NSAIDs should be taken with food, milk, or antacids. If these symptoms persist for more than a few days, it is important to consult a healthcare provider. Other serious side effects that require immediate medical attention include black or tarry stools, cloudy urine, blood in urine or vomit, severe stomach pain, unusual weight gain, blurred vision, ringing in the ears, photosensitivity, and severe headaches.
NSAIDs may also interact with other medications and reduce their effectiveness. For example, they can enhance the effect of warfarin, a blood-thinning medication. NSAIDs should be used cautiously, for the shortest time possible, and at the lowest effective dose. It is important to consult a healthcare provider to weigh the risks and benefits of using NSAIDs and to determine the appropriate treatment plan.
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Corticosteroids
Despite their benefits, corticosteroids can cause side effects, and the chances of experiencing these side effects increase with prolonged use. Possible side effects include muscle weakness, mood swings, anxiety, restlessness, trouble sleeping, increased body hair, Cushing syndrome, high blood pressure, osteoporosis, and infections. People with diabetes should closely monitor their blood sugar levels when taking corticosteroids as they can raise blood sugar levels.
Corticosteroid-induced myopathy is a potential adverse effect characterised by muscle weakness and atrophy of type 2b muscle fibres. This condition can be challenging to diagnose, as symptoms may be attributed to the underlying condition being treated. However, it can be confirmed when muscle weakness improves after tapering or discontinuing corticosteroids.
In summary, corticosteroids are potent medications that can effectively reduce muscle inflammation and treat chronic soft-tissue injuries. While they offer rapid relief, it is crucial to be aware of their potential side effects and follow the prescribed usage instructions to minimise risks.
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Natural supplements
Some natural supplements that may help heal muscle inflammation include omega-3 fatty acids, which are abundant in fatty fish such as salmon or tuna. Plant-based sources of omega-3s include flax and chia seeds, which contain short-chain alpha-linolenic acid (ALA). However, it is the long-chain omega-3 fatty acids—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—that have the majority of the health benefits.
Curcumin, a traditional Indian medicinal herb, is another natural supplement with anti-inflammatory properties. It can be found in the spice aisle, as well as in capsules, creams, drinks, and sprays. Studies show that curcumin can help with certain conditions, including arthritis, inflammatory bowel disease, and fatty liver disease.
Zinc is another natural supplement with anti-inflammatory properties. The recommended daily intake of zinc is 11 mg for males and 8 mg for females. However, taking more than 40 mg per day can be dangerous, as it can reduce immune function and lower 'good' cholesterol levels.
Other natural supplements that may help heal muscle inflammation include vitamin A, vitamin E, ginger, and green tea extract. Vitamin A can be found in liver, fish oils, milk, eggs, and leafy greens, while vitamin E can be found in olive oil, almonds, peanuts, meat, dairy products, leafy greens, and fortified cereal. Ginger root is commonly used in cooking and has anti-inflammatory properties, which may help reduce inflammation related to several health conditions, including type 2 diabetes. Green tea may also fight inflammation, as regions that consume more green tea have lower rates of inflammation-related illnesses.
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Physical therapy
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat muscle inflammation and the aches, pains, and stiffness that come with it. NSAIDs can be purchased over the counter and include medications such as aspirin, ibuprofen, and naproxen sodium. However, NSAIDs can have side effects, especially with long-term use, and may not be suitable for everyone. It is important to consult a doctor before taking NSAIDs.
In addition to medication, physical therapy can be an effective way to treat muscle inflammation. Physical therapy can be particularly helpful for individuals suffering from chronic inflammation, which can lead to arthritis, obesity, bowel disease, and diabetes if left untreated. A physical therapist will provide a program to help control dangerous levels of inflammation and make movements easier and less painful.
Therapeutic exercise can reduce pain, swelling, and muscle tension, as well as improve muscle function and blood circulation. During physical therapy, a therapist may use heat or cold therapy to deliver long-term results. Heat therapy increases circulation to injured tissues and is beneficial for muscle spasms, muscle tightness, and joint pain. Cold therapy, on the other hand, is better for recent injuries or acute throbbing pain, as it reduces inflammation and swelling.
Gentle stretching can also help prevent stiffness while muscles recover, and a physical therapist can guide patients on when and how to stretch. Massage can also be used to relieve tension and restore blood flow to sore muscles, and athletes often use sports massage to recover from exercise faster. Ultrasound therapy is another safe technique used in physical therapy that has been shown to produce anti-inflammatory effects.
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Over-the-counter medications
Over-the-counter (OTC) medications are drugs that you can buy without a doctor's prescription. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat muscle aches, strains, and sports injuries. NSAIDs can reduce pain, fever, and inflammation. Common NSAIDs include aspirin, ibuprofen, and naproxen sodium. These medications can be effective for relieving symptoms, but they don't help the body heal and may even slow down the natural healing process. NSAIDs can also cause side effects, especially with long-term use or when taken in large doses. The most frequently reported side effects are gastrointestinal issues such as feeling bloated, stomach pain, nausea, vomiting, and constipation. NSAIDs can also cause more serious side effects, including kidney and gastrointestinal damage, and they may interact with other medications. Therefore, it is important to consult with a healthcare provider before taking NSAIDs, especially if you have certain health conditions such as stomach ulcers, kidney disease, liver disease, or heart problems.
In addition to NSAIDs, there are other OTC options for treating muscle inflammation. Some OTC products combine acetaminophen and anti-inflammatory medication. It is important to read the ingredients list on all OTC medications to know how much of each drug you are taking and to avoid taking too much of any active ingredient, which could increase the risk of side effects. Additionally, OTC medications should be stored in a cool, dry place to maintain their effectiveness.
While OTC medications can be convenient and effective for treating muscle inflammation, they may not be suitable for everyone. It is always a good idea to consult with a healthcare professional before taking any new medication, especially if you have any health conditions or are taking other medications that could interact with the OTC drugs. For example, people with cardiovascular disease may have an increased risk of heart-related issues from taking NSAIDs. Additionally, NSAIDs can interact with blood pressure medications and blood thinners like low-dose aspirin.
If you are looking for alternative options to OTC medications, there are some natural supplements that may help relieve muscle pain and inflammation. However, it is important to note that the U.S. Food and Drug Administration (FDA) does not regulate all supplements, so it is important to do your research and consult with your doctor before taking any supplements to ensure they are safe and will not interfere with your other medications or health conditions. Physical activity and gentle stretching can also help prevent muscle stiffness and keep your musculoskeletal system healthy. Massage and heat or cold therapy can also help relieve muscle tension and soreness.
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Frequently asked questions
NSAIDs, or Nonsteroidal Anti-Inflammatory Drugs, are medications that can reduce pain, fever, and inflammation. Common NSAIDs include aspirin, ibuprofen, and naproxen.
Some people develop mild side effects from taking NSAIDs, such as feeling bloated, stomach pain, nausea, and constipation. More serious side effects include lightheadedness, balance issues, and difficulty concentrating. NSAIDs can also cause gastrointestinal issues and increase the risk of ulcers, especially if taken without food.
Yes, there are natural supplements that can help relieve muscle pain and inflammation. However, it is important to consult with a doctor before trying any complementary treatments to ensure they are safe and do not interfere with other medications. Physical activity is also one of the best ways to reduce muscle inflammation.
In addition to medications, rest, physical therapy, and gentle stretching can help with muscle inflammation. Massage and cold or heat therapy can also relieve tension and reduce inflammation.







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