
Cymbalta (duloxetine) is a medication used to treat depression, anxiety, fibromyalgia, and chronic pain. Like all medicines, it can cause side effects, including dry mouth, nausea, and sexual side effects. Some people have also reported muscle weakness and unusual tiredness while using this medicine. It is important to consult a healthcare provider to ensure the information applies to your personal circumstances, as side effects may vary depending on the individual.
| Characteristics | Values |
|---|---|
| Muscle weakness | Unusual tiredness or weakness, decreased urine output, difficulty concentrating, fast or irregular heartbeat, headaches, memory problems, nausea or vomiting, swelling of the face, ankles, or hands, trouble breathing |
| Other side effects | Skin reactions, allergic reactions, seizures, low sodium level, liver damage, low blood pressure, serotonin syndrome, increased blood pressure, sexual problems, kidney problems, blurred vision, dizziness, drowsiness, trouble with thinking, blood sugar level changes |
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What You'll Learn

Low sodium levels in the blood
Hyponatremia can occur due to various factors, including prolonged vomiting or diarrhea, which deplete the body's water and sodium content. It can also result from excessive water intake, diuretic use, certain medications, or specific medical conditions. Some of the symptoms of hyponatremia include nausea, headaches, muscle spasms, confusion, fatigue, and in severe cases, seizures and coma.
If you suspect hyponatremia, it is crucial to seek medical attention. A diagnosis is typically confirmed through blood tests, and immediate treatment is necessary to avert serious health complications. Treatment may involve reducing fluid intake, adjusting medication, or, in severe cases, hospitalisation for intravenous sodium replacement.
Certain medications, such as Cymbalta (duloxetine), have been associated with hyponatremia. It is always advisable to consult a healthcare professional when taking any medication to understand potential side effects and monitor for any changes in your health.
Additionally, it is important to be vigilant about any unusual symptoms while taking Cymbalta. Side effects may include muscle pain, unusual tiredness or weakness, skin reactions, and allergic reactions. If you experience any of these symptoms, it is imperative to contact your doctor promptly.
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Allergic reactions
Cymbalta (duloxetine) is a medication that treats depression, anxiety, fibromyalgia, and certain types of chronic pain. It is also used to treat nerve damage associated with diabetes (diabetic peripheral neuropathy).
Like all medicines, Cymbalta can cause side effects in some people, although most people have no side effects or only minor ones. These side effects can vary depending on the individual and may be temporary, lasting a few days to weeks.
Some people may experience an allergic reaction to Cymbalta. Symptoms of an allergic reaction can be mild or serious and may include:
- Skin rash
- Itching
- Hives
- Swelling of the face, lips, tongue, or throat
- Blistering, peeling, or loosening of the skin
- Red skin lesions, often with a purple centre
- White spots in the mouth or on the lips
- Fevers or flu-like symptoms with a rash
- Red rash with swelling of the face, lips, or lymph nodes in the neck or underarms
If you experience any of these symptoms, stop taking Cymbalta and contact your healthcare provider right away. In rare cases, an allergic reaction to Cymbalta can lead to anaphylaxis, a serious and potentially life-threatening condition. Signs of anaphylaxis include swelling of the lips, mouth, throat, or tongue, very fast breathing or struggling to breathe, and a tight feeling in the throat. If you experience any of these symptoms, seek immediate medical attention.
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Liver damage
Cymbalta, also known as duloxetine, is a medication used to treat depression, anxiety, fibromyalgia, and certain types of chronic pain. It is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) that works by increasing the levels of these neurotransmitters in the brain, resulting in an antidepressant effect. While Cymbalta can be an effective treatment for many people, like all medications, it may cause side effects in some individuals.
Several cases of duloxetine-induced liver injury have been reported, including in patients with and without pre-existing liver disease or chronic alcohol use. The mechanism by which duloxetine causes liver injury is not yet fully understood, but it is thought to be related to its metabolism in the liver. The onset of liver injury typically occurs within 1 to 6 months of starting the medication, and symptoms may include right upper belly pain, loss of appetite, nausea, light-coloured stool, dark yellow or brown urine, yellowing of the skin or eyes, and unusual weakness or fatigue.
It is important to note that not all cases of duloxetine-induced liver injury result in acute liver failure, and some instances may be asymptomatic. However, clinicians should carefully monitor liver function in patients taking duloxetine, particularly those with risk factors such as pre-existing liver disease or chronic alcohol use. If you experience any symptoms indicative of liver injury, it is crucial to seek medical advice promptly.
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Sexual problems
Cymbalta (duloxetine) is a medication used to treat depression, anxiety, fibromyalgia, and certain types of chronic pain. It is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) that increases the levels of serotonin and norepinephrine in the brain, improving mood, sleep, appetite, and energy levels.
While Cymbalta has proven effective in reducing morbidity and mortality associated with depression, it can cause various side effects, including sexual dysfunction in approximately 46% of patients. This side effect is more frequently reported in men than in women, but it can impact both genders.
The sexual side effects of Cymbalta include:
- Decreased sexual desire and libido in both men and women: This is due to the increased serotonin levels inhibiting dopamine function, which is responsible for promoting sexual desire and arousal.
- Delayed or no orgasm in women: Cymbalta may make it difficult to achieve orgasm or result in unsatisfying orgasms.
- Delayed ejaculation in men: While this may be beneficial for men with premature ejaculation, it can also lead to decreased sexual satisfaction.
If you experience sexual side effects while taking Cymbalta, it is important to discuss them openly with your healthcare provider. They may recommend changes to your medication, such as adjusting the dosage or timing, or suggest alternative treatments. Additionally, coping strategies such as talking to your partner and seeking therapy can help you manage these side effects.
It is worth noting that most side effects of Cymbalta will subside after a few weeks as your body adjusts to the medication. However, sexual side effects may persist throughout the course of treatment.
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Withdrawal symptoms
Duloxetine, sold under the brand name Cymbalta, is a medication that treats depression, anxiety, fibromyalgia, and certain types of chronic pain such as nerve, bone, or joint pain. It is also used for pain caused by nerve damage associated with diabetes (diabetic peripheral neuropathy).
Cymbalta can cause withdrawal symptoms, especially when stopping the drug suddenly. It is important not to stop taking Cymbalta suddenly without first consulting a doctor. If you have been instructed to stop taking Cymbalta, a doctor can advise on how to slowly decrease the dose, reducing the chance of experiencing withdrawal symptoms. The most commonly reported side effects of Cymbalta include nausea, somnolence, headache, and dizziness. Other possible withdrawal symptoms include:
- Increased sweating
- Irritability
- Nightmares
- Trouble sleeping
- Prickling or tingling feelings
- Blurred vision
- Drowsiness
- Trouble with thinking
- Vomiting
- Diarrhea
- Muscle pain
- Unusual tiredness or weakness
These withdrawal symptoms can be temporary, lasting a few days to weeks. However, if they last longer, are bothersome, or become severe, it is important to consult a doctor or pharmacist for advice and to discuss other treatment options.
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Frequently asked questions
Cymbalta (duloxetine) is a brand-name delayed-release oral capsule that is used to treat depression, anxiety, fibromyalgia, and certain types of chronic pain.
Yes, muscle weakness is a known side effect of Cymbalta. It can be caused by low sodium levels in the blood (hyponatremia) which is a potential side effect of the drug.
Cymbalta has a range of potential side effects, including nausea, dry mouth, drowsiness, dizziness, and blurred vision. It can also cause allergic reactions, sexual problems, and liver damage.
If you experience any side effects from Cymbalta, you should talk to your doctor or pharmacist. They may be able to suggest ways to manage the side effects or discuss alternative treatment options. Do not stop taking Cymbalta without first consulting your doctor.








