
Hydroxychloroquine is a medication used to treat and prevent malaria. It is also used to treat lupus and arthritis. While it is usually well tolerated, it can cause rare side effects, including muscle weakness. This side effect is more likely with longer use and higher doses of the medication. If you experience any muscle weakness while taking hydroxychloroquine, it is important to consult your healthcare provider. They may recommend periodic monitoring of your muscle strength and reflexes and may adjust your dosage or recommend alternative medications if necessary.
| Characteristics | Values |
|---|---|
| Muscle Weakness | A rare side effect of hydroxychloroquine, more likely with long-term use and higher doses. |
| Risk Factors | Age, kidney issues, nerve damage, and higher doses. |
| Precautions | Consult a doctor if muscle weakness interferes with daily activities. |
| Treatment | Discontinuing hydroxychloroquine may reverse muscle weakness. |
| Other Side Effects | Heart problems, vision changes, skin reactions, low blood glucose, blood cell count changes, and retinopathy. |
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What You'll Learn
- Hydroxychloroquine can cause nerve damage, leading to muscle weakness
- Muscle weakness is more likely with long-term use and higher doses
- Hydroxychloroquine may cause suicidal thoughts or actions in a small number of people
- It can cause low blood sugar, which can be serious and may lead to death
- Hydroxychloroquine can cause permanent vision problems

Hydroxychloroquine can cause nerve damage, leading to muscle weakness
Hydroxychloroquine is an effective treatment for malaria, a red blood cell infection transmitted by mosquito bites. It is also used to prevent malaria infection in areas where there is no known medicine to treat it. In addition, hydroxychloroquine is used to treat discoid lupus erythematosus (DLE) or systemic lupus erythematosus (SLE or lupus) and acute and chronic rheumatoid arthritis.
Other rare side effects of hydroxychloroquine include changes in blood cell counts, vision changes, and heart problems such as QT prolongation. These side effects are more likely to occur with long-term use and higher doses of the medication. It is recommended that patients taking hydroxychloroquine have an eye examination before or while taking the medication to monitor for any vision changes.
Serious skin reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, can also occur during treatment with hydroxychloroquine. It is important to consult a doctor immediately if any unusual symptoms or side effects develop while taking hydroxychloroquine.
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Muscle weakness is more likely with long-term use and higher doses
Muscle weakness is a rare side effect of taking hydroxychloroquine. This drug is used to treat or prevent malaria, lupus, and rheumatoid arthritis. It works by altering the immune system's response to threats, which can decrease the number of important blood cells in the body.
In rare cases, hydroxychloroquine can cause nerve damage that leads to muscle weakness. This side effect is more likely with long-term use and higher doses of the medication. Some studies indicate that this can occur in about 13% of people receiving long-term treatment with hydroxychloroquine. The risk is higher for people with kidney issues or older individuals.
Patients taking hydroxychloroquine for a long time or at high doses are at an increased risk of permanent vision problems. They may experience blurred vision, temporary disturbances in accommodation, or extraocular muscle palsies. Additionally, there is a risk of developing retinopathy, which can lead to irreversible changes in the eye.
Long-term use and high doses of hydroxychloroquine are also risk factors for the development of cardiomyopathy, which can lead to cardiac failure, conduction disorders, and sudden cardiac death. It is important for patients requiring long-term therapy to be appropriately monitored by their healthcare providers.
If you experience muscle weakness while taking hydroxychloroquine, it is important to reach out to your healthcare team for guidance. They may recommend periodic monitoring of your muscle strength and reflexes and adjust your treatment plan if necessary.
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Hydroxychloroquine may cause suicidal thoughts or actions in a small number of people
Hydroxychloroquine is a medicine used to treat and prevent malaria, an infection from parasites that can lead to death. It is also used to treat rheumatoid arthritis, systemic lupus erythematosus, and discoid lupus erythematosus. While hydroxychloroquine can be effective in treating these conditions, it is important to be aware of its potential side effects.
In rare cases, hydroxychloroquine can cause nerve damage, leading to muscle weakness. This side effect is more likely to occur with longer use and in individuals with kidney issues or advanced age. It is recommended that individuals taking hydroxychloroquine be monitored periodically for muscle weakness through knee and ankle reflex response tests.
Additionally, hydroxychloroquine may cause suicidal thoughts or actions in a small number of people. This adverse effect typically occurs within the first month of taking the medication. It is crucial for individuals taking hydroxychloroquine to be aware of this potential risk and seek immediate medical assistance if they experience any suicidal ideation.
The U.S. Food and Drug Administration (FDA) has evaluated reports of suicidal thoughts and actions associated with certain medications, particularly those used for type 2 diabetes and obesity. While their preliminary findings did not establish a direct link, the small number of suicidal cases observed warrants further investigation. Healthcare professionals should monitor patients taking these medications and advise them to report any unusual changes in mood or the emergence of suicidal thoughts.
It is important to note that the occurrence of suicidal thoughts or actions is a complex issue that may be influenced by multiple factors. If you or someone you know is experiencing suicidal ideation, it is imperative to seek professional help immediately.
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It can cause low blood sugar, which can be serious and may lead to death
Hydroxychloroquine is an effective medication for treating and preventing malaria. It is also used to treat lupus and arthritis. While it is usually well-tolerated, it can cause several side effects, including muscle weakness, nerve problems, and low blood sugar.
Low blood sugar, or hypoglycemia, is a rare but serious side effect of hydroxychloroquine. It occurs more frequently in people with diabetes, especially when they start the medication or adjust their dosage. Diabetic patients taking hydroxychloroquine should closely monitor their blood glucose levels and inform their healthcare team if they frequently have readings below 70 mg/dL.
Low blood sugar can lead to serious complications, including seizures, loss of consciousness, and death. Therefore, it is crucial for patients taking hydroxychloroquine to be vigilant about monitoring their blood sugar levels and reporting any abnormalities to their healthcare providers. Additionally, patients should be aware of the signs and symptoms of low blood sugar, such as dizziness, confusion, hunger, and sweating, and seek immediate medical attention if they experience these symptoms.
While muscle weakness is a rare side effect of hydroxychloroquine, it can be indicative of more serious underlying issues. It is recommended that patients taking hydroxychloroquine who experience muscle weakness undergo periodic testing, including knee and ankle reflex response examinations. In some cases, further neurological evaluation may be necessary to rule out more severe conditions.
Hydroxychloroquine can cause a decrease in white blood cell count, red blood cell count, and platelets. These blood cells are crucial for fighting infections, carrying oxygen throughout the body, and clotting to stop bleeding. Therefore, patients taking hydroxychloroquine should be vigilant about monitoring their health and reporting any signs or symptoms of infection, fatigue, or unusual bleeding to their healthcare team.
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Hydroxychloroquine can cause permanent vision problems
Hydroxychloroquine is an effective treatment for malaria, discoid lupus erythematosus, and rheumatoid arthritis. However, it can cause rare but serious side effects, including permanent vision problems.
Hydroxychloroquine can cause damage to the retina, which is part of the eye. This can lead to permanent vision changes or even loss of vision. The risk of developing these vision problems increases with long-term use and higher doses of the medication. People who are older, have kidney or liver disease, or have underlying retinal disease are also at a higher risk.
To mitigate this risk, it is recommended that patients have an eye examination before or while taking hydroxychloroquine. Patients should also notify their eye doctor when on this medication so that regular visual screening tests can be performed. If any vision changes occur, patients should stop taking hydroxychloroquine and contact their healthcare provider immediately.
In addition to vision problems, hydroxychloroquine can also cause muscle weakness, nerve problems, and low blood sugar. These side effects are rare but can be serious and may require medical attention. Patients experiencing any of these side effects should consult their healthcare provider for further guidance and management.
It is important to note that hydroxychloroquine should only be taken as prescribed by a doctor. Patients should not stop taking the medication without first consulting their healthcare team, as this could lead to a flare-up of symptoms related to their underlying health condition.
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Frequently asked questions
Yes, muscle weakness is a rare side effect of hydroxychloroquine. This side effect is more likely to occur with long-term use and higher doses of the medication.
If you experience muscle weakness while taking hydroxychloroquine, you should stop taking the medication and contact your healthcare provider. They may recommend tests to check for muscle or nerve problems and may adjust your treatment plan.
Hydroxychloroquine is generally well-tolerated, but some people may experience side effects such as nausea, diarrhea, skin rashes, hair changes, vision changes, and low blood sugar. In rare cases, it can also cause serious skin reactions, heart problems, and retinopathy. It is important to monitor for any side effects while taking this medication and to consult a healthcare provider if any concerns arise.











































