
Irritable bowel syndrome (IBS) is a functional disorder that affects the body's functioning, but doctors cannot identify any visible abnormalities. IBS is characterised by cramping, bloating, and constipation or diarrhoea. In addition to these gastrointestinal symptoms, IBS patients may also experience non-digestive symptoms such as muscle aches and fatigue. This occurs in as many as half of people with IBS, and a 2018 study found a possible link between dysfunctional serotonin regulation and fatigue in women with IBS.
| Characteristics | Values |
|---|---|
| Muscle fatigue | A 2016 review found that fatigue occurred alongside other IBS symptoms, including bowel-related symptoms, psychological distress, and health-related impacts on quality of life. It was also found to be more common among younger females. |
| A 2018 study found a possible link between dysfunctional regulation of serotonin and fatigue in women with IBS. | |
| A 2017 meta-analysis found that consuming a low FODMAP diet may relieve symptoms of IBS, including fatigue. | |
| Other symptoms | Cramping, bloating, constipation or diarrhea, headache, back pain, frequent urination, bad breath or a bad taste in the mouth, sleep difficulties, muscle aches, cold, clammy, or trembling hands, heart palpitations, dizziness, pain during menstruation or intercourse |
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What You'll Learn

The link between IBS and fibromyalgia
Irritable bowel syndrome (IBS) and fibromyalgia are both functional disorders, meaning that the body is not working as it should, but doctors cannot identify any visible issues. Both disorders involve chronic pain and are largely associated with stress. They are also both more common in women than in men.
IBS is a gastrointestinal disorder characterised by abdominal pain, bloating, and altered bowel habits such as constipation and diarrhoea. Diarrhoea occurs when the muscles in the gut contract more than necessary, disrupting the rhythmic movement of the gut. IBS can also cause constipation by slowing down gut muscle contractions. Up to 60% of people with IBS have fibromyalgia, and the two disorders often coexist for years.
Fibromyalgia is a disorder of the nervous system, characterised by widespread musculoskeletal pain throughout the body. It can also cause fatigue and trouble sleeping. In some studies, as many as one-third of fibromyalgia patients were also diagnosed with IBS. Researchers at the Cedars-Sinai Medical Center found that subjects with IBS had a high prevalence of small intestinal bacterial overgrowth (SIBO), which may provide a link between the two disorders.
The exact nature of the link between IBS and fibromyalgia is not yet well understood. However, many pain experts believe that they are a single lifelong disorder that causes pain in different places over time. Both disorders involve pain symptoms that cannot be explained by biochemical or structural abnormalities, and they share similar clinical characteristics and overlapping symptoms.
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How IBS affects gut muscle contractions
Irritable bowel syndrome (IBS) is characterised by abdominal symptoms, including constipation, diarrhea, gas, and bloating. IBS can affect the gut in various ways, including how the gut muscles contract and move food through the gastrointestinal (GI) tract.
IBS can disrupt the normal rhythm of gut muscle contractions, which can lead to either constipation or diarrhea. In a healthy individual, the gut contracts and relaxes in a rhythmic manner to produce a bowel movement. However, in individuals with IBS, this rhythm is disrupted, leading to excessive or insufficient contractions.
When gut muscle contractions are sped up, it can result in diarrhea, known as IBS-D. This occurs when the muscles in the gut contract more than they need to, leading to lower abdominal pain and cramping. Diarrhea associated with IBS can be related to how the brain and gut communicate, although research into this connection is still ongoing.
On the other hand, when gut muscle contractions are slowed down, it can result in constipation, known as IBS-C. In this case, the gut muscles do not contract as much as they should, making it difficult to pass stool. IBS-C can be challenging to distinguish from chronic idiopathic constipation, another functional gastrointestinal disorder.
The colon (large intestine) muscle tends to contract more in people with IBS, leading to cramps and pain. This dysmotility, or impaired movement, is a key feature of IBS and can cause significant discomfort and bowel irregularities.
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Non-gastrointestinal symptoms of IBS
Irritable bowel syndrome (IBS) is a common condition that affects the digestive system. While IBS is not known to cause tissue damage in the gastrointestinal tract or increase the risk of more severe conditions, it can lead to various non-gastrointestinal symptoms that significantly impact an individual's quality of life.
One of the most prevalent non-gastrointestinal symptoms associated with IBS is fatigue. Research indicates that as many as half of all people with IBS experience fatigue or exhaustion. A 2016 review found that fatigue often accompanies other IBS symptoms, including bowel-related issues, psychological distress, and health-related impacts on quality of life. Interestingly, fatigue was found to be more common among younger females with IBS, suggesting a potential link between hormonal factors and fatigue in this population.
Another non-gastrointestinal symptom of IBS is pain. People with IBS may experience abdominal pain and cramps, which can be uncomfortable and disruptive to daily life. This pain is believed to be related to increased brain activity in regions that process pain, resulting in an enhanced sense of pain perception. Additionally, there is a recognised connection between IBS and fibromyalgia, a condition characterised by widespread pain in the skin and deep tissue. The link between these two conditions suggests that managing pain is an essential aspect of treating IBS for many patients.
The psychological impact of IBS cannot be overstated. Beyond the physical symptoms, IBS can lead to psychological distress, including anxiety and depression. This mental health component underscores the importance of treating both the physical and mental aspects of the condition equally. Seeking support for the psychological challenges that accompany IBS can be crucial for effective management.
While not directly causing muscle damage, IBS can indirectly lead to muscle-related issues. For example, IBS can cause muscle cramps and pain, particularly when experiencing diarrhea due to disruptions in the rhythmic contractions and relaxations of the gut muscles. Additionally, some individuals with IBS may benefit from incorporating gentle exercises like yoga or tai chi, which can help build muscle strength while also providing mental calming effects.
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The role of psychological factors in IBS
Irritable Bowel Syndrome (IBS) is a common, chronic gastrointestinal disorder characterised by recurring episodes of abdominal pain and altered bowel habits. While the exact cause of IBS is unknown, biological, psychological, and sociological factors are believed to contribute to its onset, severity, and progression.
Psychological factors play a crucial role in moderating symptom severity, symptom persistence, treatment-seeking behaviour, and response to treatment. Stress, in particular, is widely recognised as a factor that influences IBS. Stressful life events, such as work-related stress, family problems, financial worries, and other anxieties, can trigger or exacerbate IBS symptoms. This creates a cycle where the stress of living with IBS further aggravates the bowel symptoms, leading to increased stress levels.
Several psychological variables have been identified as important contributors to IBS severity. These include maladaptive coping styles, such as catastrophizing, which refers to an exaggerated negative interpretation of stressful events, and somatization, which is the expression of psychological distress through physical symptoms. Anxiety also plays an intermediary role in IBS, as it is associated with both increased catastrophizing and somatization. Other psychological factors, such as neuroticism and life stressors, contribute to IBS by increasing anxiety levels.
Research has also found a link between IBS and psychological distress, including fatigue, bowel-related symptoms, and health-related impacts on quality of life. This link was found to be more prevalent in younger females. Additionally, a 2018 study suggested a potential connection between dysfunctional serotonin regulation and fatigue in women with IBS.
While the exact mechanisms are not yet fully understood, it is clear that psychological factors play a significant role in IBS. Treatment approaches often focus on improving coping strategies and reducing somatization to effectively manage IBS symptoms.
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Food sensitivities and IBS
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder that affects 10-20% of adults in the United States. It is characterised by abdominal symptoms such as constipation, diarrhoea, gas, and bloating. While the pathophysiology of IBS is not yet fully understood, it is believed to be a multifactorial condition influenced by various factors, including disturbed motility, visceral sensitivity, central processing, genetic factors, psychological factors, and inflammation.
Food sensitivities play a significant role in IBS. Food intolerance, which occurs when the body reacts to the chemical components of food, is common in individuals with IBS. This intolerance can lead to adverse food reactions, with up to 65% of IBS patients reporting that their symptoms are related to specific foods. The perception of food hypersensitivity in IBS is higher than in the general population, with 20-65% of patients attributing their symptoms to food sensitivities.
People with IBS may have a lower pain tolerance and experience visceral hypersensitivity, where their digestive tract is highly sensitive to abdominal pain or discomfort. Their gut may also be abnormally sensitive, reacting to certain foods by triggering spasms and filling with gas or fluid. High FODMAP foods, such as beans, brussels sprouts, cabbage, onions, leeks, garlic, pulses, cereal husks, and fatty foods, can aggravate IBS symptoms. FODMAPs, or "fermentable oligosaccharides, disaccharides, monosaccharides, and polyols," are types of carbohydrates that can cause inflammation or irritation in the gut, leading to increased intestinal gas and other IBS symptoms.
To manage IBS symptoms related to food sensitivities, dietary modifications are often recommended. The low FODMAP diet has been shown to be effective in relieving symptoms by reducing the consumption of hard-to-digest carbohydrates and providing alternative nutrient sources. Additionally, gluten-free diets may be beneficial for individuals with IBS, even if they do not have celiac disease, as they tend to be more sensitive to gluten. It is important to work with a healthcare provider when making dietary changes to ensure adequate nutrient intake and avoid potential deficiencies.
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Frequently asked questions
Fatigue is a common symptom of IBS, with up to half of people with IBS experiencing fatigue or exhaustion. However, it is not clear whether IBS directly causes muscle fatigue.
IBS stands for irritable bowel syndrome. It is a functional disorder where the body does not function properly, but doctors cannot identify anything physically wrong.
The main symptoms of IBS are related to the digestive system, including cramping, bloating, and constipation or diarrhea. However, there are also non-gastrointestinal symptoms such as headache, back pain, frequent urination, fatigue, and muscle aches.
There is currently no cure for IBS, but symptoms can be managed through diet, exercise, and medication. A low FODMAP diet may relieve symptoms, and cardio exercise can help build muscle strength. Over-the-counter pain medications like ibuprofen or aspirin can be used alongside antidepressants.
Yes, there appears to be a connection between IBS and fibromyalgia. People with fibromyalgia are likely to also have IBS. Both conditions involve heightened brain activity in the parts that process pain, and researchers believe they may be different expressions of a single lifelong disorder.











































