
Prednisone is a corticosteroid with potent anti-inflammatory effects. It is used to treat a wide range of conditions, including skin diseases, arthritis, allergies, cancer, eye problems, and more. While it is an effective treatment, it can also cause various side effects, including an increased risk of infections, weight gain, high blood pressure, diabetes, ulcers, osteoporosis, and muscle problems. One of the muscle-related side effects of prednisone is muscle pain, which can be a sign of low potassium levels. Additionally, patients taking prednisone may experience muscle weakness and loss of muscle strength (muscle atrophy).
| Characteristics | Values |
|---|---|
| Muscle pain | Caused by low potassium levels |
| Cause of low potassium levels | Prolonged use of prednisone |
| Other side effects | Increased appetite, weight gain, high blood sugar, steroid-induced diabetes, skin changes, excess hair growth, thinning of bones, slow growth in children, increased risk of cancer, upset stomach, mood changes, loss of appetite, weight loss, adrenal gland problems, high blood pressure, increased risk of infections |
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What You'll Learn

Prednisone can cause bone and muscle problems, such as osteoporosis
Prednisone is a corticosteroid with potent anti-inflammatory effects. It is used to treat a number of conditions, including skin diseases, arthritis, allergies, asthma, blood disorders, cancer, eye problems, kidney problems, ulcerative colitis, and multiple sclerosis. While prednisone can be effective in managing these conditions, it is important to be aware of its potential side effects, particularly its impact on bones and muscles.
Prolonged use of prednisone, especially at high doses (greater than 20 milligrams per day), can lead to thinning of the bones, a condition known as osteoporosis. This side effect predisposes individuals to joint damage, most commonly in the hips, resulting in pain and loss of joint function. Additionally, prednisone can cause muscle weakness and loss of muscle strength (muscle atrophy). Patients taking prednisone may experience muscle cramps and muscle pain, which can be signs of low potassium levels.
To mitigate the risk of bone and muscle problems, patients taking prednisone should engage in regular physical exercise. This helps to prevent muscle deconditioning and can also aid in maintaining bone health. It is also important for patients to be aware of their calcium and vitamin D intake while on steroids, as these nutrients are crucial for bone health. Bone density measurements, such as DEXA scans, can be used to monitor bone health in individuals taking prednisone for extended periods.
Furthermore, prednisone may increase the risk of infections, including minor fungal infections and more serious infections such as pneumonia. Patients taking prednisone should be cautious and avoid exposure to sick individuals. They should also inform their doctor if they have had any previous serious infections, such as tuberculosis or hepatitis B. Additionally, prednisone can cause weight gain, increased appetite, fluid retention, and changes in blood sugar levels, potentially leading to steroid-induced diabetes.
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It can increase your risk of infections
Prednisone is a corticosteroid with potent anti-inflammatory effects. It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. It is used to treat conditions such as skin diseases, arthritis, breathing problems, blood disorders, severe allergies, cancer, and eye problems.
Prednisone may increase your risk of infections, including serious infections. It is important to call your healthcare provider right away if you have an infection or any symptoms such as a high temperature, chills, a very sore throat, ear or sinus pain, a cough, more saliva or a change in the colour of saliva, pain when you pee, mouth sores, or a wound that will not heal. These can be signs of an infection.
Before starting treatment with prednisone, it is important to inform your healthcare provider if you have ever had tuberculosis (TB), hepatitis B, or any other serious infections. Some types of microbes that cause infections (such as bacteria or viruses) can remain in the body after recovery. Prednisone may increase the risk of these latent microbes becoming active again and causing an infection.
While on prednisone, it is important to avoid people who are sick or have infections and to practice good hand hygiene. If exposed to chickenpox or measles, it is crucial to inform your doctor immediately. Additionally, do not receive any immunizations or vaccinations without consulting your doctor first. Prednisone may lower your body's resistance, and there is a chance of getting the infection the vaccine is meant to prevent. It is also important to avoid close contact with individuals who have recently received live virus vaccines, as they could potentially pass the virus to you.
The risk of infections is higher with increased steroid doses and longer durations of therapy. Combining prednisone with other immunosuppressive medications further increases the risk of infections. Taking specific types of antibiotics prophylactically may help reduce the risk of certain infections.
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It can cause weight gain and water retention
Prednisolone, a type of prednisone, can cause weight gain and water retention. This is due to the drug's ability to increase hunger and fluid retention by altering brain chemicals. If you have to take prednisolone for more than a few weeks, it is likely that you will put on weight. To manage this, it is recommended to eat well-balanced meals without increasing portion sizes and to engage in regular exercise. Once you stop taking prednisolone, your appetite and water retention should return to normal.
Prednisone can also cause other side effects such as a rounder face, which may occur after weeks or months of taking the medication. Cushing's syndrome, characterised by weight gain in the upper back or belly and a puffy, rounded face, can develop as a result of prolonged prednisone use. Additionally, patients taking prednisone may experience muscle weakness and loss of muscle strength (muscle atrophy). Regular physical exercise is recommended to counteract this side effect.
In children and teenagers, long-term use of prednisone at higher doses can slow down normal growth. Doctors will carefully monitor the height and weight of young patients taking this medication to spot any potential growth abnormalities. While prednisone use may slow growth in children, it does not appear to have a significant effect on their eventual adult height.
Furthermore, prednisone has been associated with an increased risk of osteoporosis, or thinning of the bones. Patients taking high doses of prednisone, such as more than 20 milligrams per day, are predisposed to joint damage, particularly in the hips. Avascular necrosis of the hip, also known as osteonecrosis, can cause pain and loss of joint function. As such, patients taking prednisone for prolonged periods are typically advised to take additional medications to prevent osteoporosis.
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Prednisone can cause thinning of the skin, making bruising easier
Prednisone is a corticosteroid with potent anti-inflammatory effects. It is used to treat conditions such as skin diseases, arthritis, breathing problems, blood disorders, severe allergies, cancer, and eye problems. It can also be used to treat rheumatic diseases, which are inflammatory conditions that affect joints, tendons, ligaments, bones, and muscles.
In addition to skin changes, prednisone can cause other side effects, including increased appetite, weight gain, fluid retention, and steroid-induced diabetes. It can also increase the risk of infections, including serious and life-threatening infections. Patients taking prednisone should be aware of these potential side effects and report any concerns to their healthcare provider.
To reduce the side effects of prednisone, regular physical exercise is recommended. Eating well-balanced meals can also help to avoid excess weight gain and lower the risk of high blood pressure, diabetes, ulcers, and bone and muscle problems. Patients taking prednisone should also be mindful of their calcium and vitamin D intake, as the medicine can cause thinning of the bones (osteoporosis). Bone density measurements are often done using DEXA scans to monitor bone health.
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It can lead to steroid-induced diabetes
Prednisone is a corticosteroid, or steroid, that provides relief for inflamed areas of the body. It is used to treat inflammation, severe allergies, adrenal problems, arthritis, asthma, endocrine problems, eye or vision problems, stomach or bowel problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis.
Prednisone can affect how the body reacts to insulin, causing insulin resistance. Insulin resistance, or steroid-induced diabetes, occurs when the cells no longer respond to insulin, regardless of whether the body produces it naturally or it is injected to control diabetes. Steroid-induced diabetes is characterised by consistently high blood sugar levels, which can cause symptoms such as extreme thirst, frequent urination, blurry vision, and frequent infections.
The risk of developing steroid-induced diabetes is higher in people taking large doses of steroids over extended periods. People with pre-existing diabetes or prediabetes are particularly vulnerable to the development of steroid-induced diabetes, and should use steroids with caution. If steroids are taken for a temporary period, significant changes to the blood sugar management strategy may be required.
The symptoms of steroid-induced diabetes usually resolve soon after a person stops taking steroids. However, in some cases, steroid-induced diabetes can persist even after stopping steroid medication, and diabetes tests are recommended annually.
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Frequently asked questions
Yes, prednisone can cause muscle pain and muscle weakness. It can also cause muscle cramps and changes in heart rate, which can be signs of low potassium levels.
Prednisone is a corticosteroid with potent anti-inflammatory effects. It is used to treat conditions such as inflamed areas of the body, skin diseases, arthritis, allergies, asthma, blood disorders, cancer, and eye problems.
Some common side effects of prednisone include weight gain, increased appetite, fluid retention, high blood pressure, increased blood sugar or steroid-induced diabetes, thinning skin, and increased risk of infections.









































