
Progesterone is a naturally occurring hormone that plays a critical role in the female reproductive system. It is responsible for supporting menstruation and maintaining early pregnancy. Progesterone levels fluctuate throughout a woman's life, with levels declining in the years leading up to menopause. While progesterone is essential for various bodily functions, it can also cause side effects, particularly when taken as a medication or supplement. Common side effects include dizziness, fatigue, breast tenderness, and pain. Less common but serious side effects include muscle pain, joint pain, swelling, changes in heart rate, depression, and difficulty breathing. While rare, progesterone may also increase the risk of certain cancers, such as breast and ovarian cancer. Therefore, it is crucial to consult a doctor before taking progesterone to weigh the benefits against potential risks and side effects.
| Characteristics | Values |
|---|---|
| Muscle pain | Common side effect |
| Dizziness | Common side effect |
| Drowsiness | Common side effect |
| Increased risk of breast cancer | Rare side effect |
| Increased risk of ovarian cancer | Rare side effect |
| Increased risk of heart problems | Rare side effect |
| Increased risk of blood clotting | Rare side effect |
| Increased risk of stroke | Rare side effect |
| Endometriosis | Rare side effect |
| Uterine fibroids | Rare side effect |
| Allergic reaction | Rare side effect |
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What You'll Learn

Progesterone side effects
Progesterone is a female hormone that plays an important role in the menstrual cycle and pregnancy. Progesterone is available in prescription forms for birth control and hormone replacement therapy (HRT), as well as over-the-counter creams for menopausal symptoms. Progesterone may cause side effects, and these can vary depending on the individual.
Common side effects
Common side effects of progesterone include:
- Headaches
- Coughing
- Fatigue
- Breast tenderness or pain
- Vomiting
- Diarrhea
- Constipation
- Upset stomach
- Mood swings
- Irritability
- Vaginal discharge
- Hot flashes
- Night sweats
- Vaginal dryness
- Discomfort during sex
Less common but serious side effects
Less common but serious side effects include:
- Dizziness
- Lightheadedness
- Fainting
- Swelling
- Changes in heart rate
- Depression
- Difficulty breathing
- Vision changes
- Allergic reaction
- Skin rash
- Tightness in the chest
- Tingling in the mouth or throat
- Trouble breathing
- Swelling in the hands or face
Long-term side effects
Progesterone may also increase the risk of certain long-term health problems, including:
- Breast cancer
- Ovarian cancer
- Endometrial cancer
- Heart problems
- Blood clotting problems
- Stroke
- Endometriosis
- Uterine fibroids
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Progesterone and pregnancy
Progesterone is a naturally occurring female sex hormone that plays a crucial role in the menstrual cycle and the early stages of pregnancy. During pregnancy, progesterone levels increase steadily, peaking in the third trimester. This rise in progesterone helps prevent early labour and stops the body from ovulating, allowing the pregnancy to continue. Progesterone also thickens the uterine lining, providing a suitable environment for a fertilised egg to implant and grow into an embryo. This thickening of the uterine lining is essential for a healthy pregnancy.
Progesterone is also used in fertility treatments to support women who are at risk of preterm labour or have experienced recurrent miscarriages. Research has shown that taking progesterone supplements in the first trimester of pregnancy can increase the chances of a successful pregnancy by up to 15% for those with a history of miscarriages. Progesterone therapy in early pregnancy may also help prevent miscarriage in women who are bleeding in the first 12 weeks.
Low progesterone levels can cause complications during pregnancy and increase the risk of miscarriage. However, high progesterone levels typically do not negatively impact health, and there are usually no symptoms of high progesterone. While progesterone is crucial for maintaining pregnancy, it is important to note that taking progesterone supplements during pregnancy is generally not recommended unless prescribed by a doctor.
Like any medication, progesterone can cause side effects, although these are usually mild and may go away as the body adjusts. Common side effects include headaches, breast tenderness, nausea, diarrhoea, constipation, fatigue, and muscle, joint, or bone pain. More serious but less common side effects include dizziness, swelling, changes in heart rate, depression, difficulty breathing, and vision changes. It is important to consult a doctor if any unusual problems or side effects occur while taking progesterone.
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Progesterone and cancer risk
While progesterone is a commonly prescribed medication for hormone replacement therapy, birth control, and fertility treatment, it may cause several side effects, including muscle pain.
Progesterone may increase the risk of certain cancers, although the evidence is mixed. Some studies have shown a link between synthetic progestogens (progestins) and an increased risk of breast cancer. However, the role of endogenous progesterone in breast cancer development is less clear. While mechanistic studies suggest that progesterone may contribute to breast carcinogenesis, epidemiological data has not provided strong evidence of a direct relationship.
Additionally, progesterone may be associated with a higher chance of ovarian cancer. Laboratory studies have shown that animals given progesterone developed tumours, but it is unknown if progesterone has the same effect in humans.
Progesterone is also used to prevent abnormal thickening of the uterine lining, which can lead to endometrial or uterine cancer. In this context, progesterone helps to reduce the risk of uterine cancer.
It is important to note that the risks and benefits of taking progesterone vary from person to person, and a detailed conversation with a doctor is crucial to understanding individual risks.
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Progesterone and driving
Progesterone is a medication that can cause side effects such as headaches, breast pain, fatigue, diarrhoea, constipation, muscle pain, mood swings, dizziness, drowsiness, and fainting. It is important to note that these side effects may vary depending on the individual and may go away as the body adjusts to the medication. However, it is crucial to consult a doctor if any unusual problems or severe side effects occur.
When it comes to driving, it is important to consider the potential impact of these side effects. Progesterone may cause dizziness, drowsiness, and fainting, especially when getting up too quickly from a lying position. These side effects can impair one's ability to drive safely. Therefore, it is recommended to understand how your body reacts to progesterone before engaging in activities that require alertness, such as driving.
Additionally, progesterone may add to the drowsiness caused by certain drugs or herbs, further increasing the risk of driving or operating heavy machinery. It is crucial to discuss any medications or supplements you are taking with your doctor to assess potential interactions and side effects. This includes prescription medications, over-the-counter drugs, and herbal supplements.
Furthermore, progesterone may cause other side effects that can impact driving, such as vision changes, difficulty breathing, chest pain, and sudden loss of coordination. These side effects can be serious and require immediate medical attention. It is important to be vigilant about monitoring any unusual symptoms and seeking medical advice accordingly.
While the side effects of progesterone can vary, it is always better to be cautious when it comes to driving. If you experience any symptoms that may impair your ability to drive safely, it is recommended to refrain from driving until you have consulted with your doctor and addressed the issue. Your safety and the safety of others on the road should always be the top priority.
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Progesterone and drug interactions
Progesterone is a female hormone that is available in various forms, including tablets, capsules, gels, injections, and vaginal inserts. It is used for several purposes, such as preventing changes in the uterus in women taking conjugated estrogens after menopause, regulating menstrual cycles, and treating amenorrhea.
When it comes to drug interactions, it is important to note that progesterone can interact with other medications and supplements. According to Drugs.com, there are 222 medications known to interact with progesterone, including atorvastatin, metformin, and lamotrigine. Mixing certain medications with progesterone can have serious and even fatal consequences. Therefore, it is crucial to inform your doctor about any other medications or supplements you are taking to avoid potential side effects or interactions.
Additionally, progesterone may enhance the drowsiness caused by certain drugs or herbs, impacting your ability to drive or operate heavy machinery safely. It is also important to note that progesterone should not be used in combination with alcohol or tobacco, as these substances may cause interactions.
Furthermore, progesterone should be used with caution in elderly patients as they are more susceptible to breast cancer, stroke, or dementia, which may be influenced by the use of progesterone. It is also not recommended for use in children, as the safety and efficacy in this population have not been established.
In summary, progesterone has the potential to interact with various drugs and supplements, and it is important to consult with a healthcare professional before taking progesterone to ensure safe and effective use.
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Frequently asked questions
Progesterone can cause dizziness, drowsiness, lightheadedness, fainting, headaches, menstrual changes, breast pain, upset stomach, vomiting, diarrhea, constipation, fatigue, muscle pain, joint pain, mood swings, irritability, a runny nose, sneezing, coughing, vaginal discharge, and more.
If you experience any unusual problems or serious side effects while taking progesterone, call your doctor immediately. You or your doctor may also report serious side effects to the FDA's MedWatch Adverse Event Reporting program.
Progesterone may interact with other medications and supplements. Tell your doctor about any medications or supplements you are taking, even if they are natural, so they can check for potential side effects or interactions.
Using alcohol or tobacco with certain medicines may cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.











































