
Lupus is an autoimmune disease that causes inflammation throughout the body, affecting the skin, joints, blood, kidneys, lungs, heart, and brain. It can cause joint pain, muscle pain, and bone pain. Joint pain is a very common complaint in people with lupus, and lupus arthritis has many similarities with rheumatoid arthritis. Lupus arthritis usually affects joints farther from the middle of the body, like fingers, wrists, elbows, knees, ankles, and toes. Lupus can also cause bone tissue death (avascular necrosis or AVN) due to disrupted blood supply, which can lead to bone damage and pain. In addition, lupus often causes myalgia, or muscle pain, and less frequently, myositis, or muscle inflammation.
| Characteristics | Values |
|---|---|
| Joint pain | Very common |
| Muscle pain | Common |
| Bone pain | Caused by avascular necrosis (AVN) |
| Treatment | Nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, immunosuppressants, physical therapy, acupuncture, massage therapy, meditation, chiropractic care, acupressure |
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What You'll Learn
- Lupus can cause joint pain and inflammation, resulting in arthritis and tendonitis
- Lupus can cause bone tissue death, known as avascular necrosis (AVN)
- Lupus can cause muscle pain and inflammation, called myalgia and myositis
- Lupus can cause carpal tunnel syndrome, which affects the wrists and hands
- Lupus can cause bursitis, which is swelling in the bursae, the fluid-filled sacs that lubricate joints

Lupus can cause joint pain and inflammation, resulting in arthritis and tendonitis
Lupus is an autoimmune disease that occurs when the body's immune system attacks its own tissues and organs. It can cause joint pain and inflammation, which can lead to arthritis and tendonitis. Joint pain is a common symptom of lupus, with about 95% of lupus patients experiencing joint pain or arthritis at some point during their illness.
Lupus arthritis is caused by inflammation of the lining of the joint, resulting in swelling, tenderness, and stiffness. This inflammation can also affect the tendons and bursae, causing tendonitis and bursitis. Tendonitis is inflammation of the tendons, the tissues that connect muscles to bones, and it can cause pain and stiffness in the joints. It commonly affects the fingers, elbows, shoulders, and heels.
Lupus arthritis typically affects the joints farthest from the middle of the body, such as the fingers, wrists, elbows, toes, ankles, and knees. The stiffness is usually worse in the morning but improves throughout the day. Lupus arthritis is different from rheumatoid arthritis as it is less likely to cause permanent joint damage and bone erosions. It also tends to cause less swelling and shorter periods of morning stiffness.
The main treatment for joint pain and tendonitis caused by lupus is non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen sodium. Joint rest and physical therapy can also help ease the pain. In some cases, doctors may prescribe low doses of steroids like prednisone to reduce inflammation and pain. However, prolonged use of high doses of steroids can cause bone and muscle damage, so they are typically used only in the short term to manage acute flare-ups.
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Lupus can cause bone tissue death, known as avascular necrosis (AVN)
Lupus is an autoimmune disease where the body's immune system attacks its own tissues and organs. It can affect any part of the body, including the bones and bone tissue. One of the most common complications of lupus in the bones is avascular necrosis (AVN), which is the death of bone tissue due to a lack of blood flow. This condition affects around 10% of people with lupus, with estimates ranging from 3% to 15%.
AVN occurs when there isn't enough blood flow to a part of the bone, causing pressure to build up and the bone to weaken. Over time, this can lead to tiny cracks and eventually the collapse of the bone. The hips, shoulders, and knees are the most commonly affected areas, with the vast majority of bone damage occurring at the hip joint. The first signs of AVN are pain and stiffness in these joints, followed by muscle spasms and limited movement. As the condition advances, pain may become more severe and persistent, especially at night.
The main cause of AVN in people with lupus is the long-term use of high doses of corticosteroids, a common treatment for lupus symptoms. Other risk factors for AVN include alcohol abuse, sickle cell anemia, and joint injuries. While AVN can be a serious complication, it is important to note that it does not affect everyone with lupus. Maintaining a healthy lifestyle, sticking to your treatment plan, and being proactive about your healthcare can help reduce the risk of AVN and other bone-related issues.
If left untreated, AVN can lead to severe pain and loss of movement. Treatment options for AVN include core decompression surgery, bone grafts, and stem cell therapy. NSAIDs are often the first line of treatment for managing pain associated with AVN. Advanced cases may require more invasive procedures such as artificial joint replacement to restore movement and reduce pain. It is important to work closely with your healthcare team to monitor your symptoms and develop a treatment plan that is right for you.
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Lupus can cause muscle pain and inflammation, called myalgia and myositis
Lupus is an autoimmune disease that affects people in different ways. It occurs when the body's immune system attacks its own tissues and organs, causing inflammation throughout the body. This inflammation often leads to painful joint swelling and muscle stiffness.
The treatment for lupus-related muscle pain and inflammation depends on the specific symptoms and their severity. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or naproxen sodium, are typically the first line of treatment for muscle and joint pain associated with lupus. Physical therapy can also help strengthen muscles and improve joint flexibility, thereby reducing pain and stiffness. In cases of myositis, higher doses of steroids may be prescribed, along with disease-modifying antirheumatic drugs (DMARDs). However, steroids can have long-term side effects, so doctors carefully consider the need for and dosage of these medications. Alternative treatments, such as acupuncture, may also be explored in consultation with a doctor.
It is important to note that lupus can affect tendons, which are the tissues that connect muscles to bones, leading to conditions like tendonitis (tendinitis) and carpal tunnel syndrome. Additionally, lupus can cause bone tissue death, known as avascular necrosis (AVN), due to disrupted blood flow to the bone. AVN can cause pain, stiffness, and limited movement in the affected joints.
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Lupus can cause carpal tunnel syndrome, which affects the wrists and hands
Lupus is an autoimmune disease that occurs when the body's immune system attacks its own tissues and organs. It can cause inflammation in many body systems, including the joints, skin, kidneys, blood cells, brain, heart, and lungs. While lupus affects people differently, most people with lupus experience problems with their joints, muscles, or bones. This can manifest as joint pain and inflammation, resulting in issues like arthritis, tendonitis, and carpal tunnel syndrome.
Carpal tunnel syndrome is a condition that occurs when inflammation puts too much pressure on the median nerve in the wrist, which supplies sensation to the thumb, index finger, middle finger, and part of the ring finger. This nerve compression can cause pain, tingling, and numbness in the hand and fingers, affecting grip strength and manual dexterity.
Lupus-related carpal tunnel syndrome is a result of inflammation in and around the joints, which is a common symptom of lupus. This inflammation can lead to joint pain (arthralgia) and conditions like arthritis and tendonitis. In the case of carpal tunnel syndrome, the inflammation affects the wrists and hands, causing pain and impairing hand function.
The symptoms of carpal tunnel syndrome can vary in severity and may include intermittent or constant pain, tingling, or numbness in the affected hand and fingers. Some individuals may also experience a decrease in grip strength or fine motor skills. These symptoms can impact daily activities such as writing, typing, or grasping objects firmly.
While lupus itself can cause carpal tunnel syndrome, it's important to note that treatments for lupus may also contribute to this condition. Steroids, for example, are commonly used to manage lupus symptoms but can lead to bone tissue death (avascular necrosis or AVN) if taken in high doses over an extended period. AVN can cause pain, stiffness, and limited movement in the affected joints, including the wrists and hands, further exacerbating the symptoms of carpal tunnel syndrome.
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Lupus can cause bursitis, which is swelling in the bursae, the fluid-filled sacs that lubricate joints
Lupus is an autoimmune disease that causes the immune system to attack the body's own tissues and organs. It affects different people in different ways, but most people with lupus experience problems with their joints, muscles, or bones.
Lupus can cause bursitis, which is swelling in the bursae, the fluid-filled sacs that lubricate the tissues and bones that move your joints. Scapulothoracic bursitis, for example, involves inflammation of the scapulothoracic bursa, which is located between the scapula (shoulder blade) and the chest wall. This type of bursitis is typically caused by overuse of the shoulder or a traumatic injury, especially in those who are anatomically susceptible to bursa irritation. It usually develops in athletes and is also known as snapping shoulder syndrome. While scapulothoracic bursitis is rare in patients with systemic lupus erythematosus (SLE), there have been reported cases requiring surgical excision due to unbearable pain.
In addition to bursitis, lupus can cause joint pain (arthralgia) and inflammation, leading to conditions such as arthritis, tendonitis, and carpal tunnel syndrome. Joint problems related to lupus usually do not cause long-term damage. Lupus arthritis typically affects the joints farther from the middle of the body, such as the fingers, wrists, elbows, knees, ankles, and toes. It is important to note that lupus-related arthritis is different from rheumatoid arthritis, as it tends to be less severe with less swelling and stiffness.
Lupus can also cause inflammation in the muscles (myositis), resulting in muscle weakness and pain. This typically occurs in the hips, thighs, shoulders, and upper arms. Treatment for muscle and joint pain from lupus often involves non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen sodium. In some cases, low doses of steroids like prednisone may be prescribed to manage pain and swelling during active flare-ups.
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Frequently asked questions
Yes, lupus can cause muscle and bone pain. Lupus is an autoimmune disease that causes inflammation throughout the body, including in the joints, muscles, and bones.
There are several treatments for muscle pain caused by lupus, including:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen
- Corticosteroids such as prednisone
- Immunosuppressants
- Alternative treatments like acupuncture, massage therapy, meditation, and chiropractic care
- Physical therapy
Lupus-related bone pain can be treated with:
- NSAIDs
- Corticosteroids
- Immunosuppressants
- Surgery, in severe cases of avascular necrosis (AVN)










































