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Lymphoma is a cancer that starts in the lymphatic system, which is part of the body's immune system. It can cause many uncomfortable or painful symptoms, including muscle pain. Muscle involvement is reported to occur in only 1.4% of lymphoma cases, with 0.3% occurring in Hodgkin lymphoma and 1.1% in non-Hodgkin lymphoma. Primary skeletal muscle lymphoma is a rare form of diffuse large B-cell lymphoma (DLBCL), which is the most prevalent form of non-Hodgkin lymphoma. The main symptoms of primary skeletal muscle lymphoma include muscle pain, swelling, and tenderness. Treatment for lymphoma can also cause muscle pain, as can other underlying health conditions that a person with lymphoma may have.
| Characteristics | Values |
|---|---|
| Lymphoma muscle pain occurrence | Lymphomatous involvement of muscles has been reported in only 1.4% of cases, with 0.3% occurring in Hodgkin lymphoma and 1.1% in Non-Hodgkin lymphoma. Primary skeletal muscle lymphoma is a rare disease accounting for only 0.5% of all extranodal lymphomas. |
| Muscle pain causes | The lymphoma itself may cause pain or aching. Lymphoma treatments can lead to painful side effects. People with lymphoma may have other underlying health conditions that cause pain. |
| Muscle pain treatment | Doctors can recommend strategies or prescribe medication for pain relief. Chemotherapy is often used to treat muscle pain caused by lymphoma. |
| Common symptoms | Swollen lymph nodes, tumors, enlarged organs, and aching joints or bone pain. |
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What You'll Learn
Muscle pain as a side effect of chemotherapy
Muscle pain is not a common symptom of lymphoma. Lymphomatous involvement of muscles has been reported to occur in only 1.4% of cases, with 0.3% occurring in Hodgkin lymphoma and 1.1% in non-Hodgkin lymphoma. Primary skeletal muscle lymphoma is a rare disease, accounting for only 0.5% of all extranodal lymphomas.
However, muscle pain can be a side effect of chemotherapy, which is often used to treat lymphoma. This is called chemotherapy-induced peripheral neuropathy (CIPN) and can cause tingling, numbness, or pain in the hands and feet, as well as muscle weakness in the legs. For many people, peripheral neuropathy is a short-term issue, but sometimes it can last longer or be permanent. If you are experiencing muscle pain as a side effect of chemotherapy, it is important to discuss this with your healthcare provider, as they may be able to adjust your treatment or prescribe medications to help manage the pain.
Certain chemotherapy medications, such as paclitaxel, biologic therapies (interferon or aldesleukin), or growth factors (filgrastim), are more likely to cause muscle pain. In some cases, removing the medication may relieve the muscle pain. Non-steroidal anti-inflammatory (NSAID) agents and Tylenol®, such as naproxen sodium and ibuprofen, may provide relief from musculoskeletal pain. However, if you are receiving certain types of chemotherapy, you may need to avoid NSAID drugs, and acetaminophen (Tylenol®) may be recommended instead. It is important not to exceed the recommended daily dose of Tylenol®, as it may cause liver damage.
In addition to medical treatments, complementary therapies such as massage and reflexology may help improve blood circulation, reduce muscle tension, and manage pain and discomfort. Balance exercises, such as physiotherapy, can also help improve symptoms of peripheral neuropathy. It is important to speak to your medical team before trying any complementary therapies or exercises to ensure they are safe for you.
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Primary skeletal muscle lymphoma
Lymphoma can cause muscle pain, and muscle pain can be a symptom of primary skeletal muscle lymphoma. Primary skeletal muscle lymphoma is a rare disease, accounting for only 0.5% of all extranodal lymphomas, and it mainly (>95%) consists of B-cell and non-Hodgkin type lymphomas (NHL). It is most prevalent among the elderly, with a high incidence rate. The extranodal type of NHL is identified in 20-30% of patients.
Imaging tools play a critical role in the diagnosis of primary skeletal muscle lymphoma, and the most common imaging techniques used include positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI). On MRI scans, primary skeletal muscle lymphoma exhibits certain distinctive features, such as increased signal intensity on T1-weighted images and intermediate signal intensity on T2-weighted images compared to normal muscle or fat. However, imaging features alone may not be sufficient for a definitive diagnosis, as it can be difficult to differentiate lymphoma from other diseases or soft-tissue tumors. Therefore, biopsy and pathological evaluation, such as histological and immunohistological analysis, are essential for confirming primary skeletal muscle lymphoma.
The treatment of primary skeletal muscle lymphoma depends on the type of lymphoma and typically involves chemotherapy, with or without radiation therapy or immunotherapy. The prognosis for primary skeletal muscle lymphoma is generally poor.
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Lymph node pain after drinking alcohol
Lymphoma is a general term for cancers that originate in the lymphatic system, a network of organs, vessels, and tissues that help move fluid and immune cells throughout the body. Lymphoma has two primary forms: Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). The extranodal type of NHL is identified in 20-30% of patients, and it can occur in the testis, skin, lung, bone, and central nervous system, as well as the respiratory and gastrointestinal tracts.
In some people, the affected lymph nodes can become painful after drinking alcohol, and this seems to happen more often in people with Hodgkin lymphoma. It is not one of the key symptoms in the diagnosis of lymphoma, and it is quite rare. There is a long history of this association between alcohol and pain in Hodgkin's disease. A review from 1966 described 747 patients with alcohol-induced pain linked to cancer-related illness, with Hodgkin lymphoma accounting for 40% of cases. However, alcohol-induced pain has only been linked to Hodgkin lymphoma. Scientists don't know the exact reason for alcohol-related pain in Hodgkin's disease, but one theory is blood vessel dilation. Some researchers also believe that alcohol-related lymphoma pain is caused by swelling in the lymph nodes or disease-affected tissue as a result of blood vessel dilation after alcohol consumption. This combination of blood vessel dilation and an increased inflammatory response is believed to be a big part of alcohol-related lymphoma pain.
Limited research suggests that alcohol-induced pain in those with Hodgkin lymphoma may be treated with over-the-counter pain medication, such as ibuprofen. However, limiting or abstaining from alcohol use may be the easiest way to manage this condition. If you experience swollen lymph nodes and suspect they may be related to alcohol consumption, it is essential to seek medical advice for an accurate diagnosis and appropriate treatment.
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Peripheral neuropathy
The peripheral nerves are like telephone wires, transmitting electric signals around the body from the brain to the hands and feet. When these nerves are damaged, communication is disrupted, resulting in peripheral neuropathy. The symptoms of peripheral neuropathy depend on which nerves are affected: sensory, autonomic, or motor. Sensory neuropathy, the most common type, involves the sensory nerves that carry messages from the skin and body to the brain. Autonomic neuropathy affects the nerves that control involuntary body functions such as bladder function, blood pressure, digestion, heart rate, sexual function, and sweating. Motor neuropathy affects the nerves that control movement, carrying messages from the brain to the muscles.
If you experience symptoms of peripheral neuropathy, it is important to inform your medical team as soon as possible. Early action may help prevent further damage. Tests such as electromyography (EMG), nerve conduction tests, blood tests, and MRI scans can help diagnose peripheral neuropathy and identify the affected nerves.
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Muscle pain as a symptom of lymphoma
Muscle pain can be a symptom of lymphoma, but it is more often a side effect of the treatment for lymphoma. Lymphoma is a cancer that starts in the lymphatic system and affects a type of white blood cell called lymphocytes. Lymphoma treatments can lead to painful side effects, and chemotherapy, in particular, can cause muscle pain.
Lymphomatous involvement of muscles has been reported to occur in only 1.4% of cases, with 0.3% occurring in Hodgkin lymphoma and 1.1% in Non-Hodgkin lymphoma. Primary skeletal muscle lymphoma is a rare disease, accounting for only 0.5% of all extranodal lymphomas, which mainly (>95%) consist of B-cell and non-Hodgkin types.
However, muscle pain can be a symptom of lymphoma for several reasons. Firstly, lymphoma itself may cause pain or aching. Secondly, lymphoma treatments can lead to painful side effects, and thirdly, people with lymphoma may have other underlying health conditions that lead to pain. For example, comorbidities have been found in about 3 out of 10 people with Hodgkin lymphoma and more than half of people with non-Hodgkin lymphoma. Older adults may be especially likely to have other conditions, such as diabetes-related nerve damage or arthritis, which may cause pain.
In terms of diagnosis, imaging scans, such as CT scans and MRIs, may reveal muscle swelling and serve as a tool to guide biopsy. However, biopsy and pathological evaluation are essential for the diagnosis of primary skeletal lymphoma.
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Frequently asked questions
Lymphoma can cause muscle pain, but it is rare. Lymphomatous involvement of muscles has been reported to occur in only 1.4% of cases, with 0.3% occurring in Hodgkin lymphoma and 1.1% in Non-Hodgkin lymphoma.
The most common symptom of Hodgkin lymphoma is swollen lymph nodes. Lymph nodes commonly swell if we have an infection but they usually return to normal over a short time. With lymphoma, the lymph nodes often grow slowly and may be there for months or years before they're noticed. Sometimes they grow very quickly. Usually, the swollen nodes are not painful, but some people say their lumps ache or are painful, especially after drinking alcohol.
Yes, lymphoma treatments can lead to painful side effects, including muscle pain. For example, chemotherapy often reduces white blood cell levels, but the medication pegfilgrastim can help boost these levels. However, many people have said that pegfilgrastim can be painful.
