
Eliquis (apixaban) is a blood-thinning medicine that prevents blood clotting. While it is an effective anticoagulant, it can cause muscle weakness, especially in the legs and feet. This side effect may lead to difficulty in performing basic tasks such as sitting down on a toilet seat. Although muscle weakness due to Eliquis is rare, it is a serious side effect that requires immediate medical attention. If you experience muscle weakness while taking Eliquis, it is crucial to consult your doctor right away and follow their instructions. They may recommend stopping the medication, switching to an alternative, or taking an antidote to reverse the blood-thinning effects and prevent uncontrolled bleeding. Additionally, lifestyle changes, such as dietary modifications and regular exercise, may help alleviate muscle weakness.
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What You'll Learn

Consult a doctor before stopping Eliquis
Eliquis is a blood thinner medicine that reduces blood clotting and is typically prescribed to patients who are at an elevated risk of stroke or blood clots. It is important to consult a doctor before stopping Eliquis as discontinuing the medication can have adverse effects on your health.
Firstly, stopping Eliquis may increase your risk of blood clots or stroke. This is because Eliquis is an anticoagulant, so discontinuing its use can lead to an increased risk of blood clot formation. This risk is especially heightened for patients with a history of spinal issues or surgery, as they are more susceptible to spinal or epidural blood clots, which can result in long-term or permanent paralysis.
Secondly, Eliquis may need to be discontinued under medical supervision before certain surgeries or medical procedures. This is because Eliquis can increase your risk of bleeding during and after surgery, and your doctor will be able to advise you on the appropriate time frame for discontinuing Eliquis to minimise this risk. It is important to note that you should not stop taking Eliquis and start taking a new medication without consulting your doctor first, as certain drug interactions can increase your risk of bleeding.
Additionally, if you are experiencing adverse side effects from Eliquis, such as muscle weakness, it is crucial to consult your doctor before stopping the medication. They may recommend alternative treatments or adjustments to your dosage to alleviate these side effects. Stopping Eliquis without medical advice can be dangerous, and your doctor is the best person to determine if discontinuing the medication is safe and appropriate for you.
In summary, it is always advisable to consult a doctor before stopping Eliquis to ensure your health and safety. They can provide guidance on managing side effects, advise on drug interactions, and help you discontinue the medication safely if necessary.
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Diet and exercise to reduce muscle weakness
Muscle weakness can be caused by a sedentary lifestyle, overworked muscles, or a diet that is not providing enough energy for your body. While Eliquis is known to cause muscle weakness in rare cases, improving your diet and exercise routine can help reduce this weakness.
Diet
A healthy diet with lean proteins and lots of anti-inflammatory foods can be the best medicine for muscle weakness. The best foods for muscle fatigue include:
- Fatty fish like salmon, mackerel, or sardines
- Plant sources of omega-3 fats like hemp seeds, walnuts, flax seeds, and leafy green vegetables
- Beans
- Chickpeas
- Peanuts
- Buckwheat
- Eggs
Exercise
Strength training or "resistance" exercises are the only known way to bulk up your muscles and increase your strength. Some examples of muscle-strengthening exercises include:
- Weight lifting
- Brisk walking
- Jogging
- Swimming
- Push-ups
- Sit-ups
It is recommended that you try to do at least 2 sets of muscle-strengthening activities, but doing 3 sets will gain even more benefits. Additionally, some aerobic exercises, if performed at a vigorous intensity, will also strengthen your muscles.
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Eliquis alternatives to prevent blood clots
Eliquis (apixaban) is a blood thinner medication that helps prevent and treat blood clots. It is a relatively new oral anticoagulant option that has been known to cause rare but serious side effects such as muscle weakness and bleeding. If you are experiencing any side effects, it is important to consult your doctor right away. They may recommend switching to another blood thinner medication.
Xarelto (rivaroxaban)
Xarelto is a factor Xa inhibitor that works to prevent the formation of blood clots. It is approved to lower the risk of stroke and other blood clots in people with nonvalvular atrial fibrillation. Xarelto can be used for a broader range of indications compared to Eliquis and may be preferred due to its once-daily dosing. However, it has a higher risk of major bleeding side effects.
Pradaxa (dabigatran)
Pradaxa is a direct-acting oral anticoagulant that is FDA-approved to prevent stroke and systemic embolism in people with non-valvular atrial fibrillation. It contains the active ingredient dabigatran, which blocks the clotting factor thrombin to reduce the formation of blood clots. The most common side effects of Pradaxa are indigestion, nausea, vomiting, and bleeding. Unlike Eliquis, Pradaxa can be used in certain children aged 8 years and older.
Savaysa
Savaysa is another alternative for AFib patients. It works as a factor Xa inhibitor and is typically taken once per day. The most common side effects are bleeding, rash, anaemia, and abnormal liver function tests. Savaysa is not recommended for people with moderate to severe liver problems.
Warfarin
Warfarin is an older oral blood thinner medication that has been around for a long time and is approved for use in both adults and children. It requires frequent monitoring and close attention to your diet during treatment. It is available as a generic medication and may be more affordable than newer options.
Aspirin
Aspirin works as an antiplatelet to prevent platelets from forming blood clots.
Ginger and Turmeric
Ginger and turmeric are natural alternatives that may help stop blood clotting. However, more studies are needed to fully understand their blood-thinning effects and potential drug interactions.
It is important to consult with your healthcare provider before starting, stopping, or switching any medication to ensure the best option for your specific needs and health conditions.
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Side effects of Eliquis
Eliquis (apixaban) is a prescription medicine used to reduce the risk of stroke and blood clots in people with atrial fibrillation (AFib). It is also used to treat blood clots in the veins of the legs (deep vein thrombosis) or lungs (pulmonary embolism). Eliquis is a blood thinner, which means it reduces blood clotting. While Eliquis has many benefits, it can also cause several side effects, including:
- Bleeding: Eliquis can cause serious bleeding, which in rare cases can lead to death. This may require a blood transfusion or surgery. Bruising more easily and prolonged bleeding are also common side effects.
- Muscle weakness: This is a rare but serious side effect of Eliquis. It can cause leg weakness and affect a person's ability to walk or sit down easily.
- Allergic reactions: Some people may experience allergic reactions to Eliquis, including hives, rash, itching, and trouble breathing. In rare cases, it can lead to anaphylaxis, a serious allergic reaction that requires immediate medical attention.
- Increased risk of blood clots or stroke: Stopping Eliquis suddenly can increase the risk of blood clots or stroke. It is important to consult a doctor before discontinuing the medication.
- Other side effects: Dizziness, tiredness, weakness, nausea, and heart palpitations are also reported side effects of Eliquis.
It is important to note that not everyone will experience all of these side effects, and the benefits of Eliquis may outweigh the risks for many individuals. However, it is crucial to be aware of the potential side effects and to seek medical advice if any adverse reactions occur.
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Eliquis and spinal procedures
Eliquis is a prescription medicine used to treat blood clots in the veins of the legs (deep vein thrombosis) or lungs (pulmonary embolism). It is also used to reduce the risk of blood clots in people with atrial fibrillation (AFib), an irregular heartbeat not caused by a heart valve problem. Eliquis is a blood thinner, or anticoagulant, that works by reducing blood clotting.
While Eliquis is effective in preventing blood clots, it can cause rare but serious side effects, including muscle weakness and bleeding. Muscle weakness is a rare but serious side effect of Eliquis, as reported by some patients who experienced leg weakness within a month of taking the medication. It is important to inform your physician if you experience any adverse reactions and not to stop taking Eliquis unless advised by your doctor.
In the context of spinal procedures, there are several important considerations regarding Eliquis:
- Spinal/Epidural Hematoma: Eliquis can increase the risk of spinal or epidural hematomas, especially during neuraxial anesthesia or spinal puncture procedures. These hematomas may result in long-term or permanent paralysis. Therefore, it is crucial to consider these risks when scheduling patients for spinal procedures and to closely monitor patients for neurological impairment.
- Blood Clotting: Eliquis is a blood thinner, so it can affect blood clotting during spinal procedures. Patients taking Eliquis who undergo spinal anesthesia or spinal puncture are at an increased risk of spinal or epidural blood clots, which can lead to paralysis. Healthcare providers should closely monitor these patients for symptoms of spinal or epidural blood clots or bleeding.
- Alternative Anticoagulants: If a patient taking Eliquis requires a spinal procedure, it may be necessary to switch to an alternative anticoagulant temporarily to reduce the risk of complications. However, this should be done under medical supervision, as premature discontinuation of Eliquis can also increase the risk of thrombotic events.
- Pregnancy: Eliquis use during pregnancy and labor, especially with neuraxial anesthesia, may increase the risk of spinal hematomas and bleeding. Healthcare providers should consider the benefits and risks before neuraxial intervention and may recommend shorter-acting anticoagulants as delivery approaches.
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Frequently asked questions
Eliquis is a blood thinner medicine that reduces blood clotting. Some common side effects include bleeding, anaemia, haemorrhage, nausea, and diabetes mellitus. Rare but serious side effects include muscle weakness, blood clots in the spine or epidural area, and allergic reactions.
Muscle weakness is a rare but serious side effect of Eliquis. If you experience muscle weakness or any other side effects that bother you, seek medical help immediately and consult your doctor. Do not stop taking Eliquis without first speaking to your doctor, as this can increase your risk of blood clots and stroke.
It is important to consult your doctor and follow their instructions when taking Eliquis. Regular medical check-ups are necessary to monitor your progress and adjust the medication if needed. Before any spinal or epidural procedures, inform your doctor that you are taking Eliquis, as this may increase the risk of bleeding and paralysis.










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