
Muscle atrophy, or the wasting and loss of muscle tissue, is a common issue that can be caused by a variety of factors, including immobility, aging, malnutrition, medications, and injuries. It is characterized by a decrease in muscle mass, weakness, and numbness or tingling in the limbs. This condition can be treated through regular exercise, physical therapy, and in some cases, surgery. While muscle atrophy is often associated with age-related muscle loss, it can also occur in younger individuals who lead sedentary lifestyles or have certain medical conditions. In addition to muscle atrophy, certain muscle groups in the body are more prone to being neglected during exercise and training, such as the glutes, which can lead to imbalances and injuries.
| Characteristics | Values |
|---|---|
| Definition | Wasting or thinning of muscle mass |
| Types | Physiologic, pathologic, and neurogenic |
| Causes | Disuse, malnutrition, age, genetics, lack of physical activity, nerve problems, diseases, injury, illness |
| Symptoms | Decrease in muscle mass, one limb being smaller than the other, numbness, weakness, tingling in limbs, trouble walking or balancing, difficulty swallowing or speaking |
| Diagnosis | Physical exam, blood test, muscle or nerve biopsy, electromyography (EMG), nerve conduction studies, CT scan, MRI scan |
| Treatment | Exercise, healthy diet, physical therapy, ultrasound therapy, surgery |
| Prevention | Regular exercise, strength training, cardio, flexibility training, nutrition plan with adequate protein and calories |
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What You'll Learn

Muscle atrophy due to inactivity can be reversed with exercise and physical therapy
Muscle atrophy, or muscle wasting, involves a significant shortening of the muscle fibres and a loss of overall muscle mass. It can be caused by disuse of muscles, neurogenic conditions, malnutrition, age, genetics, or certain medical conditions. Disuse atrophy occurs when an individual does not use their muscles enough, which can be due to a sedentary lifestyle, immobility during illness or injury recovery, or old age.
Disuse (physiologic) atrophy can be reversed with regular exercise and a healthy diet. Physical therapy is an effective treatment for muscle atrophy, as it involves performing specific stretches and exercises to prevent immobility. Ultrasound therapy is also a non-invasive procedure that uses sound waves to aid in muscle healing. The amount of time it takes to regain muscle after atrophy depends on the type of atrophy and its severity. While disuse atrophy can be reversed, neurogenic atrophy, caused by nerve problems or diseases, often cannot be reversed due to the physical damage done to the nerves.
To diagnose muscle atrophy, a healthcare provider will perform a physical examination and ask about the patient's symptoms and medical history. They will look at the patient's arms and legs and measure their muscle mass. The provider may also order additional tests, such as a blood test, muscle or nerve biopsy, electromyography (EMG), or a magnetic resonance imaging (MRI) scan.
Treatment for muscle atrophy will depend on the individual case. In addition to physical therapy and exercise, nutritional intervention or surgery may be recommended. Working out in a pool can reduce the workload on the muscles and aid in recovery. It is important to note that muscle atrophy can often be prevented by including diverse exercises and ensuring proper recovery time in one's fitness routine.
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Neurogenic atrophy occurs due to nerve problems or diseases
Muscle atrophy is the wasting or thinning of muscle mass. It can be caused by the disuse of muscles or neurogenic conditions. There are three types of muscle atrophy: physiologic, pathologic, and neurogenic. While physiologic atrophy is caused by not using the muscles enough, neurogenic atrophy occurs due to nerve problems or diseases.
Neurogenic atrophy is caused by an injury or disease affecting nerves that connect to the muscles. When these nerves are damaged, they can't trigger the muscle contractions that are needed to stimulate muscle activity. When the muscles don't contract, the body thinks they are no longer needed and starts breaking them down, leading to a decrease in their size and strength. This type of atrophy tends to occur more suddenly than physiologic atrophy and is the most severe type of muscle atrophy.
Diseases and conditions that can affect these nerves include Amyotrophic Lateral Sclerosis (ALS), Guillain-Barre Syndrome, Carpal Tunnel Syndrome, Spinal Cord Injury, and Multiple Sclerosis. Polio, an infectious disease that attacks the nervous system, can also result in neurogenic atrophy.
Neurogenic atrophy can sometimes be treated with a special kind of physical therapy called electrical stimulation. This involves placing electrodes on the skin over the muscles to send small electrical impulses to the nerves and muscles, artificially contracting the muscles. Ultrasound therapy, which uses sound waves to promote muscle healing, is another treatment option. In cases of severe atrophy, surgery may be required to correct contractures, which occur when muscle tissues become fibrous and prevent movement.
The time it takes for muscles to atrophy depends on one's health condition, age, and fitness level. Neurogenic atrophy may develop sooner than physiologic atrophy, depending on these factors. Unlike physiologic atrophy, neurogenic atrophy typically cannot be reversed due to the physical damage caused to the nerves.
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Age-related muscle loss is a natural part of ageing
Age-related muscle loss, known as sarcopenia, is a natural part of ageing. It is characterised by a decrease in muscle mass, strength, and function, and it typically affects people in their 30s or 40s and beyond. The rate of muscle loss varies, with estimates ranging from 3% to 8% per decade after the age of 30, and this decline in muscle mass accelerates after the age of 60.
Sarcopenia is believed to be caused by a combination of factors, including hormonal changes, reduced physical activity, and inadequate nutrition. For instance, as people age, their bodies produce lower levels of testosterone and insulin-like growth factor (IGF-1), which are important for muscle growth and maintenance. Additionally, older men often experience anabolic resistance, which hinders their ability to effectively break down and synthesise protein.
The risk factors for sarcopenia include leading a sedentary lifestyle, malnutrition, and certain health conditions. People with seated jobs or health issues that limit their mobility are particularly susceptible to muscle atrophy due to disuse. Physiologic atrophy, or disuse atrophy, occurs when muscles are not used enough, causing the body to conserve energy by breaking down muscle tissue, resulting in reduced muscle size and strength.
The effects of age-related muscle loss can be mitigated through progressive resistance training (PRT) and a higher-protein diet. PRT involves gradually increasing workout volume, weight, repetitions, and sets as strength and endurance improve. This continuous challenge helps build muscle and prevent plateaus. Additionally, a diet rich in protein can aid in muscle growth, as protein is broken down into amino acids that the body uses to build muscle tissue.
While age-related muscle loss is a natural part of ageing, it is not an inevitable process. Through proactive measures such as PRT and nutritional interventions, individuals can effectively rebuild and maintain their muscle mass, even as they grow older.
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Certain exercises can help rebuild lost muscle
Muscle atrophy, or the wasting and thinning of muscle mass, can be caused by a variety of factors, including malnutrition, age, genetics, lack of physical activity, and certain medical conditions. This can lead to a decrease in muscle mass, with one limb appearing smaller than the other, along with numbness, weakness, and tingling in the limbs. However, the good news is that certain exercises can help rebuild lost muscle and reverse muscle atrophy.
Physiologic or disuse atrophy occurs when muscles are not used enough, and it can be reversed through exercise and improved nutrition. This type of atrophy commonly affects individuals with sedentary lifestyles, those with desk jobs, or those with health issues that limit movement. By engaging in physical activity and adopting a healthy diet, individuals can stimulate their muscles and promote growth.
The concept of muscle memory is particularly relevant when it comes to rebuilding lost muscle. Muscle memory refers to the ability of muscles to "remember" movements and actions performed repeatedly in the past. When an individual resumes exercising after a period of inactivity, their muscles can recover their size and strength more rapidly than when they initially built them. This phenomenon is attributed to the retention of muscle nuclei or myonuclei, which remain even as muscles shrink. These myonuclei are reactivated when training resumes, accelerating muscle growth and enhancing the execution of movements.
Additionally, specific exercises and training programs can be tailored to target neglected or underactive muscles. For example, engaging the Serratus muscle can aid in shoulder injuries, posture improvement, and upper body strength enhancement. Addressing imbalances and focusing on neglected muscles can help prevent injuries and improve overall fitness.
Overall, a combination of consistent exercise, proper nutrition, and targeted training programs can effectively rebuild lost muscle and restore individuals to their previous levels of strength and fitness.
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Some muscles are more neglected than others during workouts
There are over 600 muscles in the human body, and while many of them are small and don't significantly affect sports performance and orthopedic health, most of them do. Many of these muscles are often neglected when exercising and training for sports, which can lead to muscle atrophy, or the wasting and thinning of muscle mass.
Muscle atrophy can be caused by disuse of muscles, malnutrition, age, genetics, lack of physical activity, or certain medical conditions. Disuse atrophy occurs when muscles are not used enough, and the body starts to break them down to conserve energy. This can happen during a sedentary lifestyle, or when one is malnourished, has a genetic disorder, or is recovering from an illness or injury. Neurogenic atrophy, on the other hand, is caused by nerve problems or diseases that affect the nerves connecting to the muscles. This type of atrophy can occur more suddenly and may require medical treatment.
Some muscles that are commonly neglected during workouts include the Serratus (SA), the Transversus Abdominus (TVA), and the Pelvic Floor and Lumbar Multifidi muscle groups. The SA is underactive due to weaker nerve connections and the fact that it is not engaged in arm movements like push-ups and bicep curls. The TVA and Internal Obliques are also often neglected, leading to overactivity of the Rectus Abdominus and External Oblique abdominal muscles, which can undermine lumbar spine stability.
Neglecting certain muscles can lead to imbalances, injuries, and frustration when fitness goals are not met. Therefore, it is important to incorporate exercises that target a variety of muscle groups and to seek professional advice when needed to ensure a well-rounded and effective workout routine.
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Frequently asked questions
Muscle atrophy is the loss of muscle mass. It can be caused by immobility, aging, malnutrition, medications, or a wide range of injuries or diseases that impact the musculoskeletal or nervous system.
The predominant symptom of muscle atrophy is increased weakness, which may result in difficulty or inability in performing physical tasks depending on which muscles are affected. Atrophy of the throat muscles may cause difficulty swallowing, and diaphragm atrophy can cause difficulty breathing.
Muscle atrophy can be treated by making lifestyle changes, trying physical therapy, or undergoing surgery. It can also be reversed with regular exercise and physical therapy.
There are three types of muscle atrophy: physiologic, pathologic, and neurogenic. Physiologic atrophy is caused by not using the muscles enough. Pathologic atrophy is seen with aging, starvation, and diseases such as Cushing disease. Neurogenic atrophy is caused by an injury or disease affecting nerves that connect to the muscles.











































