
Muscle weakness and tiredness can be caused by a variety of factors, including ageing, lack of exercise, muscle injury, illness, and temporary inflammation. In some cases, it can be a symptom of an underlying medical condition such as chronic kidney disease, Addison's disease, or chronic fatigue syndrome. Infectious conditions such as the flu, Lyme disease, meningitis, HIV, and polio can also lead to muscle weakness. Certain neurological conditions, like multiple sclerosis and Guillain-Barré syndrome, can cause muscle weakness and tiredness. Additionally, mental health conditions such as anxiety and depression can contribute to feelings of fatigue and tiredness. It is important to consult a doctor if muscle weakness and tiredness persist or are accompanied by other symptoms, as they can help diagnose and treat any underlying causes.
| Characteristics | Values |
|---|---|
| Muscle weakness | Lack of muscle strength, muscles don't contract or move easily |
| Possible causes | Ageing, lack of exercise, muscle injury, illness, stroke, multiple sclerosis, depression, diabetes, heart disease, chronic kidney disease, anaemia, anxiety, chronic pain, infections, neurological disorders, medication, sedentary lifestyle, electrolyte imbalance |
| Muscle fatigue | Decrease in ability to perform over time, decrease in force or power production |
| Possible causes | Exercise, illness, chronic fatigue syndrome, acute or chronic fatigue, neurological disorders, stroke, spinal cord injury |
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What You'll Learn

Infections and illnesses
During and after pregnancy, high levels of steroids in the blood and a tendency towards anaemia can also cause muscle tiredness. Anaemia, which is a common condition during pregnancy, can also be caused by heavy periods, poor diet, blood loss, genetic conditions, infections, and cancers. It reduces the blood's ability to carry oxygen to the muscles, causing them to tire more easily.
Many chronic diseases can also cause muscle weakness, including chronic kidney disease, peripheral arterial disease, chronic pain, and long-term neurological damage from a stroke or spinal cord injury. In some conditions, muscle weakness is due to a reduced blood and nutrient supply to the muscles.
Infections that can cause muscle weakness include Lyme disease, meningitis, HIV, polio, and rabies.
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Lack of exercise
Lack of muscle fitness, or deconditioning, is one of the most common causes of muscle weakness. It occurs when an inactive lifestyle leads to muscle wasting, where muscles become less bulky and more floppy. This is caused by the partial replacement of muscle fibres with fat. As a result, muscles tire more quickly when attempting tasks that would have been easier when the muscles were fit.
In addition to the physical effects of muscle weakness, lack of exercise can also contribute to tiredness and fatigue. Exercise is important for improving energy levels and reducing feelings of fatigue. It is well-known that exercise promotes better sleep, which can help combat tiredness caused by sleep deprivation. Furthermore, exercise can help protect against muscle fatigue by improving recovery time and ensuring the body has enough nutrients to promote healthy muscle function.
Overall, while lack of exercise can be a contributing factor to muscle weakness and tiredness, it is important to note that there may be other underlying medical or lifestyle factors at play. It is always advisable to consult a doctor or healthcare professional for personalized advice and to rule out more serious health conditions.
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Ageing
Muscle weakness and tiredness are common symptoms of ageing. From the time you are born to around the time you turn 30, your muscles grow larger and stronger. However, at some point in your 30s or 40s, you start to lose muscle mass and strength, and this loss accelerates after 75. Everyone experiences some amount of muscle loss as they age, but certain factors can contribute to more rapid muscle loss, or sarcopenia.
Sarcopenia is the age-related progressive loss of muscle mass and strength. The main symptom of the condition is muscle weakness. Sarcopenia is a type of muscle atrophy primarily caused by the natural ageing process. However, other factors, such as physical inactivity and an unhealthy diet, can also contribute to the disease. As people age, their bodies may undergo changes that play a role in developing sarcopenia. For example, the body may produce fewer proteins that muscles need to grow, leading to smaller muscle cells. Changes in certain hormones, such as testosterone and insulin-like growth factor (IGF-1), can also affect muscle fibres and lead to sarcopenia.
The outlook for sarcopenia depends on age, health, and lifestyle. Sarcopenia can significantly impact one's quality of life, making it harder to perform basic daily activities. People with sarcopenia are also at a higher risk for illness, injury, and death. However, the condition can be treated and even reversed through lifestyle changes. Strength-training programs and healthy diets that include high-quality proteins can help regain some strength and mobility. Exercise can also help prevent or slow muscle loss and weakening and improve muscle function.
In addition to sarcopenia, other age-related changes can contribute to muscle weakness and tiredness. For example, changes in the nervous system can cause muscles to have reduced tone and ability to contract. Bones also become weaker with age, as they lose calcium and other minerals, increasing the risk of breaks from falls or bumps. An inactive lifestyle can further contribute to bone wastage. Exercise can help mitigate these issues by strengthening bones and slowing the rate of bone loss. Balance and coordination exercises can also help reduce the risk of falls.
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Chronic pain
Muscle weakness and tiredness can be caused by a variety of factors, including ageing, lack of exercise, injury, illness, and various medical conditions. One of the causes that can lead to both muscle weakness and tiredness is chronic pain.
In cases of chronic pain, muscle weakness may occur as a secondary effect. The pain and discomfort associated with chronic pain can lead to disuse of muscles, resulting in a decrease in muscle strength and endurance. This can be further exacerbated by the potential for chronic pain to limit physical activity and exercise, leading to a decline in muscle fitness and flexibility.
Additionally, chronic pain can be associated with underlying conditions that may directly contribute to muscle weakness. For example, chronic pain may be a symptom of neurological or autoimmune disorders, such as myasthenia gravis, where the immune system interferes with communication between nerve and muscle cells. This disruption can result in muscle weakness and fatigue, along with other symptoms like drooping eyelids, chewing and swallowing difficulties, and slurred speech.
It is important to note that chronic pain can be complex and vary greatly in its impact on individuals. Seeking medical advice and appropriate treatment for chronic pain is essential, as it can help identify any underlying causes and contribute to a comprehensive management plan.
Furthermore, addressing chronic pain may involve a multidisciplinary approach, including medical interventions, physical therapy, psychological support, and lifestyle modifications. By managing chronic pain effectively, individuals may experience improvements in their energy levels and a reduction in muscle weakness associated with disuse or underlying conditions related to chronic pain.
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Anxiety
While muscle weakness caused by anxiety can be distressing and irritating, it is important to note that these feelings of muscular fatigue, tingling, or numbness are typically not harmful. However, it is recommended to visit a doctor to rule out any other medical or physical explanations.
There are several coping techniques and treatments available to manage sensations of muscle weakness and reduce overall anxiety levels. These include exposure therapy, which involves gently guiding individuals to face their fears in small, manageable steps. Additionally, addressing the underlying problem of anxiety through therapy and self-help treatments can help prevent further muscle weakness.
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Frequently asked questions
Muscle weakness and tiredness can be caused by a variety of factors, including lack of exercise, ageing, muscle injury, illness, and pregnancy. It can also be a symptom of an underlying medical condition, such as diabetes, heart disease, or a neurological disorder.
Treatment for muscle weakness and tiredness depends on the underlying cause. In many cases, rest, recovery, staying hydrated, and maintaining a healthy diet can improve symptoms. If symptoms are severe or persistent, it is important to consult a doctor, as it may be an indication of a more serious disorder.
Several serious conditions can cause muscle weakness and tiredness, including chronic kidney disease, Addison's disease, chronic fatigue syndrome, myasthenia gravis, multiple sclerosis, and depression. These conditions may require medical attention and treatment.











































