
Lupus is an autoimmune disease that causes the immune system to damage organs and tissues throughout the body. The disease affects different people in different ways, but most experience problems with their joints, muscles, or bones. Lupus can cause muscle pain and weakness, which may be the result of inflammation or a side effect of medication. In this article, we will explore the relationship between lupus and muscle loss, examining the causes and potential treatments for this challenging condition.
| Characteristics | Values |
|---|---|
| Muscle Loss | Myositis associated with lupus can cause muscle weakness and loss of strength in the neck, shoulders, arms, upper pelvis, and thighs. |
| Causes of Muscle Loss | Lupus causes inflammation in muscles, tendons, and joints, leading to pain and stiffness. It can also cause tendon laxity, carpal tunnel syndrome, and arthritis. |
| Treatment | Physical therapy and exercises can help regain muscle strength. Doctors can adjust medications causing muscle weakness. |
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What You'll Learn

Lupus can cause muscle pain and weakness
Lupus is an autoimmune disease that causes inflammation and damage throughout the body. It affects everyone differently, and symptoms can vary in severity and combination. Lupus can cause muscle pain and weakness, which can be a direct result of the disease or a side effect of medication.
Lupus causes the immune system to attack the body, damaging organs and tissue. This can lead to inflammation in the muscles, known as myositis, which usually occurs in the hips, thighs, shoulders, upper arms, neck, and upper pelvis. Myositis can cause muscle weakness, making it difficult to perform everyday tasks such as standing up from a chair, raising your arms, or climbing stairs. In severe cases, it may even be challenging to turn over in bed or raise your head.
The inflammation caused by lupus can also affect the tendons and bursae, leading to conditions such as tendonitis and bursitis. These conditions can result in joint pain and stiffness, particularly in the shoulders, elbows, and fingers. Carpal tunnel syndrome is another possible complication of lupus, where inflammation and pressure on the nerve in the wrist cause pain, tingling, and numbness in the hand and fingers.
Medications used to treat lupus, such as steroids, prednisone, and other corticosteroids, can also cause muscle weakness. However, this side effect usually resolves once the medication is stopped. It is important to consult a doctor before making any changes to your medication. They can help determine the underlying cause of muscle weakness and make appropriate adjustments.
Over half of people living with lupus experience muscle pain and/or weakness. This chronic pain can interfere with daily activities and favourite pastimes. To cope with muscle issues, it is recommended to consult a doctor, who can help manage symptoms and reduce the frequency of flare-ups. Physical therapy and supervised exercise programs can also help to regain muscle strength and function.
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Myositis is inflammation of the muscles
Lupus is an autoimmune disease that causes inflammation throughout the body. It can affect the skin, joints, blood, and organs such as the kidneys, lungs, and heart. Lupus can manifest in different ways, and its symptoms can vary in severity. Some people with lupus experience muscle aches and pains (myalgias), while others develop inflammation in certain muscle groups (myositis).
Myositis is a rare disease characterised by inflammation of the muscles. It can be caused by autoimmune conditions, where the body's immune system attacks its own tissues, mistaking them for foreign invaders. This inflammation can lead to muscle weakness, swelling, and pain, making it difficult to perform everyday tasks such as climbing stairs or raising your arms. The most common symptoms of myositis associated with lupus include weakness in the muscles of the neck, shoulders, arms, upper pelvis, and thighs.
Myositis can be challenging to diagnose due to its rarity and the varied presentation of symptoms. Diagnosis typically involves a medical history review, physical examination, and tests such as blood work, MRIs, and muscle biopsies. While there is no cure for myositis, treatment options are available to help manage symptoms and prevent long-term disability. Physical therapy and exercises can aid in maintaining muscle strength and improving function.
Medications used to treat lupus, such as steroids, can also contribute to muscle weakness. It is important to consult a physician if you are experiencing muscle weakness while taking prescription drugs, as they can adjust your medication or recommend alternative treatments. Additionally, certain medications can cause temporary muscle damage, which may resolve with rest and recovery.
Lupus can affect tendons and bursae, leading to conditions such as tendonitis and bursitis, resulting in joint pain and stiffness. It can also cause carpal tunnel syndrome, characterised by pressure on the median nerve in the wrist, causing pain, tingling, and numbness in the hand and fingers. Overall, lupus can have a significant impact on muscles, tendons, and joints, requiring ongoing management and treatment to alleviate symptoms and improve quality of life.
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Lupus medications can cause muscle weakness
Lupus is an autoimmune disease that causes inflammation and damage to organs, tissues, skin, joints, blood, and muscles throughout the body. The specific symptoms of lupus vary from person to person, and they can range in severity. Lupus can cause muscle pain and weakness, which is often a result of inflammation.
Lupus medications can also cause muscle weakness. For instance, steroids taken to treat lupus can lead to muscle weakness as a side effect. This adverse effect usually subsides once the medication is discontinued, but it is important to consult a doctor before making any changes to prescription medications. Other medications that may cause muscle weakness include prednisone, other corticosteroids, drugs to lower cholesterol, and hydroxychloroquine (Plaquenil®).
It is important to note that muscle weakness can also be caused by reduced physical activity due to muscle or joint pain associated with lupus. Over half of people living with lupus experience muscle pain and/or weakness. Therefore, maintaining physical activity within one's capabilities is crucial to preventing muscle weakness. A rheumatologist can help develop a suitable physical activity plan, and physical therapy can aid in strengthening muscles.
Additionally, lupus raises the risk of osteoporosis, a condition that weakens bones and increases the likelihood of fractures. Bone density tests can help diagnose osteoporosis, as it usually presents no symptoms until a fracture occurs. Avascular necrosis (AVN) is another bone condition associated with lupus, particularly in individuals taking high doses of steroids for extended periods. AVN causes bone tissue death due to insufficient blood flow, leading to increased pressure and eventual bone collapse.
In summary, lupus medications, such as steroids and other drugs, can cause muscle weakness as a side effect. However, muscle weakness may also result from the disease itself or reduced physical activity due to lupus-related pain. Managing lupus symptoms through medication and appropriate physical activity can help mitigate muscle weakness and improve overall well-being.
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Lupus arthritis affects joints further from the body's core
Lupus is an autoimmune disease that causes inflammation throughout the body. It makes the immune system damage organs and tissue instead of protecting them. Lupus arthritis is caused by inflammation of the lining of the joint, leading to swelling, tenderness, and stiffness.
Lupus arthritis most often affects joints farther from the middle of the body, like the fingers, wrists, elbows, knees, ankles, and toes. This is known as inflammatory arthritis, and it can make joints hurt and feel stiff, tender, warm, and swollen. Lupus arthritis is less likely to cause permanent joint damage than rheumatoid arthritis, and it rarely causes bone erosions. Symptoms of lupus arthritis are usually of shorter duration and may migrate from one joint to another.
About 95% of lupus patients experience arthritis or arthralgias (joint pains) at some point. Polyarthralgia and polyarthritis, defined as arthralgias or arthritis affecting five or more joints, are the most common joint problems in people with lupus. Lupus arthritis has been observed to resemble rheumatoid arthritis in that it typically affects the small joints of the hands, wrists, and feet symmetrically. However, lupus arthritis usually does not cause bone erosion, and the hands may only appear deformed due to laxity of the tendons or ligaments. This condition is called Jaccoud's arthropathy, and the fingers can be manually straightened but will curve to one side if left unattended.
Large joints, such as the knees, shoulders, and elbows, can also be affected by lupus arthritis. Joint pain is a common complaint among lupus patients, and it may interfere with their daily activities. The pain may be in the joint lining (true arthritis) or the soft tissues around the joint, including muscles, tendons, or ligaments. Lupus can also cause tendonitis, or inflammation of the tendons, resulting in pain and usually affecting the elbows, fingers, and shoulders.
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Lupus can cause carpal tunnel syndrome
Lupus is an autoimmune disease that causes inflammation throughout the body. It makes the immune system damage organs and tissue instead of protecting them. Lupus affects different people differently, but most people with lupus experience problems with their joints, muscles, or bones. The condition can cause joint pain and inflammation in and around the joints, resulting in tendonitis, arthritis, and carpal tunnel syndrome.
Carpal tunnel syndrome is a condition where inflammation puts too much pressure on the central nerve in the wrist, causing pain, tingling, and numbness in the hand and fingers. Lupus can cause inflammation and pressure on this nerve, resulting in carpal tunnel syndrome. The inflammation associated with lupus can also cause tendonitis, which is inflammation in the tendons or tissues that connect muscles to bones. This usually affects the elbows, fingers, and shoulders.
Lupus can also cause myositis, or inflammation of certain muscle groups, which can lead to muscle weakness and atrophy. Myositis associated with lupus typically affects the hips, thighs, shoulders, upper pelvis, and upper arms. This muscle weakness can make it difficult to perform everyday tasks such as standing up from a chair, raising your arms, or climbing stairs. In severe cases, it may even be challenging to raise your head or turn over in bed.
Medications used to treat lupus, such as steroids, prednisone, and other corticosteroids, can also contribute to muscle weakness. However, this side effect usually resolves when the medication is discontinued. It is important to consult a doctor before making any changes to your prescribed medication. Additionally, lupus increases the risk of developing osteoporosis, a bone disease that weakens the bones and makes them more susceptible to fractures.
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Frequently asked questions
Lupus is an autoimmune disease that makes your immune system damage organs and tissue throughout your body. It causes inflammation that can affect your skin, joints, blood and organs like your kidneys, lungs and heart.
Lupus can cause inflammation of certain muscle groups (myositis), usually in the hips, thighs, shoulders, upper pelvis, and upper arms. The most common symptom of myositis is muscle weakness.
It is possible to regain muscle strength through exercise. A physical therapist can develop and supervise an exercise program to help keep your muscles strong. Some other ways to cope with muscle loss include distracting yourself and focusing on your favourite activities.











































