
Peripheral neuropathy is a condition that involves damage to the peripheral nervous system, which is a network of nerves that sends signals between the central nervous system (CNS) and other body parts. The CNS comprises the brain and spinal cord. Peripheral neuropathy affects millions of people in the US, particularly those with diabetes. It can cause a range of symptoms, including weakness, muscle cramps, twitching, pain, numbness, burning, and tingling, often in the feet and hands. Motor nerve damage, which controls muscles and movement, can lead to muscle weakness and is one of the four main types of peripheral neuropathy, along with sensory, autonomic, and combination neuropathy.
Characteristics and Values Table for Peripheral Neuropathy
| Characteristics | Values |
|---|---|
| Definition | Peripheral neuropathy refers to the many conditions that involve damage to the peripheral nervous system, which is a vast communications network that sends signals between the central nervous system (the brain and spinal cord) and all other parts of the body. |
| Types | More than 100 types of peripheral neuropathy have been identified, each with its own symptoms and likely course of progression. |
| Causes | Peripheral neuropathy has many different causes, including diabetes, vitamin B12 deficiency, industrial and athletic injuries, chemotherapy drugs, and genetic inheritance. |
| Symptoms | Symptoms vary depending on the type of nerves affected (motor, sensory, or autonomic). Common symptoms include weakness, muscle cramps, twitching, pain, numbness, burning sensations, and tingling, often in the feet and hands. In some cases, it can lead to paralysis. |
| Diagnosis | Diagnosis can be challenging due to the varied symptoms and body parts affected. Doctors may take a full medical history, perform neurological tests, and conduct blood tests, nerve conduction tests, imaging scans, and nerve biopsies to determine the location and extent of nerve damage. |
| Treatment | While there is no cure for peripheral neuropathy, controlling underlying conditions, such as diabetes, and managing symptoms through medication and lifestyle changes can prevent the problem from worsening and help reduce pain. |
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What You'll Learn

Motor nerve damage
Peripheral neuropathy is an umbrella term for a range of conditions that cause damage to the peripheral nervous system. This system is a network of nerves that sends signals from the brain and spinal cord to the rest of the body. Peripheral neuropathy affects millions of people in the US, with over 100 types of the condition identified.
The symptoms of motor nerve damage can vary depending on the location and severity of the nerve damage. In some cases, the damage may be permanent, and surgical intervention may be required. For example, spinal accessory nerve injury is a type of peripheral nerve damage that can cause weakness or atrophy of the trapezius muscle. This injury can be caused by trauma or surgery and often requires physical therapy for recovery.
To diagnose peripheral nerve damage, a doctor will take a detailed medical history and perform neurological tests to determine the location and extent of the damage. Electrical conduction tests, such as electromyography and nerve conduction velocity, can also be used to assess the passage of electrical currents through the nerves. Imaging techniques may also be employed to visualise the damage.
While peripheral neuropathy cannot usually be cured, healthy lifestyle changes can help to manage the pain and symptoms. This includes quitting smoking, caring for wounds, and practising relaxation techniques such as yoga.
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Sensory nerve damage
Peripheral neuropathy refers to the many conditions that involve damage to the peripheral nervous system, which is a vast communications network that sends signals between the central nervous system (the brain and spinal cord) and all other parts of the body. There are more than 100 types of peripheral neuropathy, each with its own set of symptoms and prognosis.
Sensory nerves transmit information such as the feeling of a light touch, temperature, or pain from a cut. This type of nerve damage affects the nerves that control what you feel. For example, you may feel a burning pain or numbness in a certain body part. Infections from viruses such as varicella-zoster (which causes chickenpox and shingles), West Nile virus, cytomegalovirus, and herpes simplex target sensory fibers, causing attacks of sharp, lightning-like pain.
The symptoms of sensory nerve damage can range from mild to severe and can greatly disrupt your ability to work and go about your daily activities. They can cause problems—sometimes severe—with mobility, balance, and coordination. For example, if you are unable to feel pain or temperature in your hand due to nerve damage, you may accidentally touch something hot and burn yourself without realizing it.
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Autonomic nerve damage
Peripheral neuropathy is a type of damage to the peripheral nervous system, which is a vast communications network that sends signals between the central nervous system (the brain and spinal cord) and all other parts of the body. There are more than 100 types of peripheral neuropathy, each with its own set of symptoms and prognosis.
The symptoms of autonomic nerve damage can vary depending on which nerves are affected. They might include dizziness and fainting when standing, caused by a sudden drop in blood pressure, urinary problems, sexual dysfunction, and digestion issues. These symptoms can develop slowly over years, and the impact on the body can be serious.
Doctors use terms such as autonomic neuropathy to describe the specific type of nerve damage involved. While peripheral neuropathy cannot usually be cured, healthy lifestyle choices can help to prevent it from worsening. This includes quitting smoking, treating injuries promptly, and managing any underlying conditions, such as diabetes, that may be contributing to nerve damage.
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Treatment options
Peripheral neuropathy refers to the many conditions that involve damage to the peripheral nervous system, which is a vast communications network that sends signals between the central nervous system (the brain and spinal cord) and all other parts of the body. There are more than 100 types of peripheral neuropathy, each with its own set of symptoms and prognosis.
Peripheral neuropathy can be treated in several ways, depending on the underlying cause and the patient's medical history, personal preferences, and other factors. Here are some treatment options:
- Treating the underlying cause: If peripheral neuropathy is caused by an underlying condition such as diabetes, treating that condition first is crucial. For example, controlling diabetes through lifestyle changes like stopping smoking, reducing alcohol intake, maintaining a healthy weight, and exercising regularly can help improve neuropathy.
- Medications: Various medications are available to treat neuropathic pain, including amitriptyline, duloxetine, pregabalin, gabapentin, and tramadol (a powerful opioid painkiller). Capsaicin, a substance found in chilli peppers, can be applied topically as a cream or patch to relieve pain in specific areas.
- Vitamin supplementation: Peripheral neuropathy caused by vitamin B12 deficiency can be treated with B12 injections or supplements.
- Immunoglobulin injections: In some cases, injections of immunoglobulin, a mixture of blood proteins or antibodies produced by the immune system, may be used to treat peripheral neuropathy.
- Physiotherapy: Muscle weakness, a common symptom of peripheral neuropathy, can be managed through physiotherapy. Patients can learn exercises to improve muscle strength and mobility.
- Orthotics and braces: Using orthotics, braces, or splints can help improve walking and provide support to weak ankles or other affected joints.
- Relaxation techniques: Practices like yoga can help ease emotional and physical symptoms associated with peripheral neuropathy.
- Healthy lifestyle choices: Adopting a healthy lifestyle, including quitting smoking, caring for wounds, and managing diabetes, can help reduce pain and improve overall well-being.
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Diagnosis
Peripheral neuropathy refers to the many conditions that involve damage to the peripheral nervous system. This system is a large network that sends signals between the central nervous system (CNS)—the brain and spinal cord—and the rest of the body. Peripheral neuropathy affects millions of people in the US alone.
There are more than 100 types of peripheral neuropathy, each with its own symptoms and prognosis. The symptoms and body parts affected can vary so widely that diagnosis can be challenging. Doctors will often break the condition down into categories to help with diagnosis and treatment. These categories include:
- Motor neuropathy: Damage to the nerves that control muscles and movement in the body, such as moving your hands and arms or talking.
- Sensory neuropathy: Damage to the nerves that control what you feel, such as pain, temperature, or a light touch.
- Autonomic nerve neuropathy: Damage to the nerves that control functions that you are not conscious of, such as breathing and heartbeat.
- Combination neuropathies: A mix of two or three of the above types of neuropathies, such as a sensory-motor neuropathy.
Doctors can diagnose peripheral neuropathy by obtaining a medical history, performing a physical exam, and ordering specific tests. During the medical history, doctors will ask about diabetes, autoimmune disease, vitamin deficiency, alcohol intake, family history of inherited nerve conditions, and personal history of trauma to the extremities. The physical examination will include a close inspection of the skin on the feet, as this area is often affected by peripheral neuropathy, and older patients may not be able to examine their feet properly. Doctors may discover cuts, blisters, or other injuries that patients haven’t noticed, especially if they have limited sensation in their feet.
Diagnostic tests may include blood tests to check for nutritional deficiencies or other health conditions; nerve conduction tests and electromyography to measure how electrical currents flow through nerves and muscles; spinal tap or lumbar puncture to analyse spinal fluid; nerve biopsy to examine nerve tissue; and imaging tests such as MRI or CT scans to rule out other conditions.
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Frequently asked questions
Peripheral neuropathy refers to the many conditions that involve damage to the peripheral nervous system, which is a vast communications network that sends signals between the central nervous system (the brain and spinal cord) and all other parts of the body.
Peripheral neuropathy can cause muscle weakness. Motor nerve damage causes muscle weakness, and symptoms may include painful cramps and muscle twitching, muscle loss, bone degeneration, and changes in the skin, hair, and nails.
Symptoms of peripheral neuropathy include weakness, muscle cramps, twitching, pain, numbness, burning, and tingling (often in the feet and hands). Other symptoms include gaps in sensation, strength, or discoordination in different body parts, such as the feet, legs, hands, or arms.
There is no cure for peripheral neuropathy, but treatments are available to help control or minimize symptoms. Doctors can help patients control underlying conditions (like diabetes) and manage symptoms to prevent the problem from worsening.











































